Fed and fasted state

Question 1

First enzyme in glycolysis in pancreas

Answer 1

Hexokinase

Question 2

Km and affinity in the pancreas

Answer 2

High KM and low affinity for glucose- reach Vmax at higher concentration

Question 3

Liver’s form of hexokinase

Answer 3

Glucokinase

Question 4

Enzyme that makes glycogen

Answer 4

Glycogen synthase

Question 5

Enzyme that breaks down glucose

Answer 5

Glycogen phosphorylase

Question 6

Which GLUT protein is insulin responsive

Answer 6

GLUT 4- when insulin is released you get more GLUT 4

Question 7

Fitter individuals have more of which GLUT protein

Answer 7

GLUT 4

Question 8

Key regulatory step enzyme

Answer 8

Phosphofruktokinase

Question 9

How are pathways switched on/off

Answer 9

Depending on insulin or glucagon signal

Question 10

VLDL use

Answer 10

Pack up denovo fat around the liver and ship it around the body

Question 11

Occurrences in the absorptive state

Answer 11

Carbohydrate intake
Increased insulin and decreased glucagon
Increase in glucose breakdown, increase glycogen storage, increase glycerol synthesis
Increase TAF synthesis in adipose and liver
Increased protein synthesis