Fertilization Flashcards

(63 cards)

1
Q

Capacitation

A

glycoprotein coat and seminal plasma proteins are removed from the plasma membrane that overlies the acrosomal region of the spermatozoa.

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2
Q

Acrisomal reaction

A

Release of acrosin, esterase or neuroaminidase

Elicited by zona pellucida

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3
Q

Phases of fertilization

A

Penetration of corona radiata
Penetration of zona pellucida
Fusion of the sperm and oocyte plasma membrane
Completion of 2°meiotic division/ Formation of female pro nucleus
Formation of male pro nucleus
Fusion of pronucleuses

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4
Q

Phases of embryology

A
Zygote
Morula
Blastomere
Gastrula
Neurula
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5
Q

Results of fertilization

A

Restoration of the diploid number of chromosomes
Determination of chromosomal sex of the new individual
Initiation of cleavage

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6
Q

Zygote transported to uterus by

A

Peristalsis

Ciliary beats

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7
Q

First week of development

A

Cleavage
Blastocyst formation
Implantation begins

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8
Q

30 hrs after fertilization

A

2 cell stage

Blastomere

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9
Q

Day three

A

Morula

16 cells

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10
Q

Day 4

A

Uterine fluid gushes in
Trophoblast and embryoblast formed
Blastocele

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11
Q

Day 5

A

Blastocyst(100-150 cells)
Zona pellucida degraded
HCG released

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12
Q

Day 6

A

Implantation begins

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13
Q

After implantation functional endometrial layer converted to

A

decidua

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14
Q

Day 8

A

Syncithiotrophoblast and cytotrophoblast
Hypoblast and Epiblast
Amniotic cavity forms

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15
Q

Trophoblasts

A

Enzyme for zona pellucida degradation

Release Human chorion gonadotropin

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16
Q

endometrial stromal cell become swollen & filled with glycogen called

A

decidual reaction

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17
Q

mediate initial attachment of the blastocyst to the uterus

A

L selectin on trophoblast cells and its carbohydrate receptors on the uterine epithelium

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18
Q

Cytotrophoblast

A

Secrete enzymes for uterine breakdown

Products absorbed by Syncythiotrophoblast

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19
Q

Placenta previa

A

Near internal os

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20
Q

Day 9

A

Lacunae form
Exocoelomic membrane
Fibrin coagulum

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21
Q

Day 11-12

A

Blood flows into the lacunae forming uteroplacental circulation
Extraembryonic mesoderm forms and cavities begin to form between them
Decidua reaction

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22
Q

Extra embryonic cavity aka

A

Chorionic cavity

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23
Q

13 day

A

Masses pinch of the primary yolk sac and form the secondary yolk sac and the exocolemic cyst

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24
Q

3rd week

A

characterized by formation of primitive streak and 3 germ layers

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25
By gastrulation stage we can identify
craniocaudal axis cranial and caudal ends dorsal and ventral surfaces right and left sides
26
Remnants of primitive streak
Sacrococcygeal Teratomas
27
Functions of notochord
Defines primordial axis of the embryo Provides rigidity to the embryo Serves as a basis for the development of the axial skeleton Indicates the future site of the vertebral bodies/column Regulates differentiation of surrounding structures Nucleus pulposus
28
Remnants of notochordal tissue give rise to
Chordomas
29
Inward movement of epiblast
Invagination
30
embryonic mesoderm separate ectoderm and endoderm completely except
Oropharyngeal membrane cranially Cloacal membrane caudally In the middle cranial to primitive node where notochordal process extends
31
Process of formation of neural plate, neural folds & their closure to form neural tube
Neurulation
32
Nerulation induced by
Notochord formation
33
Somites development
Intraembyonic mesoderm-> paraxial mesoderm->somites
34
Somites function
Axial skeleton Musculature Dermis
35
agents such as drugs and viruses that produce or increase the incidence of congenital anomalies
Teratogens
36
Teratogens
agents such as drugs and viruses that produce or increase the incidence of congenital anomalies.
37
Neural tube forms the
CNS
38
Neural crest forms the
PNS
39
The cranial pit becomes the& separated from gut tube by .
oral pit (stomodeum) , oropharyngeal membrane
40
The caudal pit becomes the separated from caudal end of primitive gut by .
anal pit (proctodeum), cloacal membrane
41
Dorsal end of yolk sac
Primitive gut
42
Primitive gut
Foregut Midgut Hindgut
43
The development of the cardiovascular system is essential because
diffusion of nutrients by the early uteroplacental circulation can no longer satisfy the nutritional needs of the rapidly developing embryo
44
Derivatives of Ectoderm
Attractoderm | Mouth, eyes, hair, skin, nervous system, adrenal medulla, pituitary gland, nail, anus, mammary gland
45
Mesoderm derivatives
Musculoderm or CT | Muscle, dermis, bone, cartilage, adrenal cortex, circulatory system, kidney, gonad, spleen
46
Endoderm derivatives
Tubingderm | Liver, pancreas, respiratory tract, GI tract, lower urinary tract, thyroid, thymus
47
9th-12th week
Primary ossification centers appear Urine formation Genitalia distinguished
48
13-16th week
Rapid growth Ossification begins Primordial follicles
49
17th-20th week
Growth slows down Fetal movements are commonly felt by the mother The skin is covered with vernix caseosa. covered with fine hair called lanugo Uterus formed Testes begins descent Brown fat forms
50
21st-25th week
Weight gain | Surfactant
51
Surfactant secreted by
types II pneumocytes
52
26th-29th
Safe for Pre mature birth | Eyes open
53
30th-34th week
Pupillary light reflex Pink skin Descent of testis continues till 32nd week or above 8% fat
54
35th-38th week
``` Firm grasp 16% fat Prominent chest White or bluish-pink skin Testes in scrotum ```
55
MULTIPLE PREGNANCIES cause
multiple ova & abundant spermatozoa = Dizygotic or Multizygotic May develop by splitting of the zygote, morula, or blastocyst = Monozygotic
56
Dizygotic twins
Two ova and two sperm Placenta may fuse Separate amnion and chorion
57
When placenta fuse, the blood vessels may anastomose & blood mixes forming blood group
chimesas
58
Monozygotic twins
One ova and one sperm | Splitting
59
Early separation
30 hours after fertilization | 2 chorion, placenta and amnion
60
Implanted close
Separated at 1 week 1 chorion and placenta 2 amnion
61
Late separation
2 weeks 1 amnion, chorion and placenta Conjoined, parasitic, or separate twins
62
site of attachment of conjoined (Siamese) twins
Thoracopagus Pygopagus Craniopagus Omphalopagus Craniothoracopagus Massive fusion
63
the fertilization of two or more oocytes at different times.
Superfecundation