Fever Flashcards

1
Q

Fever is especially common in _______ Most is caused by ____________ serious bacterial infections are more common in____________ highest risk age group is __________

A

under 2s
mild viral infections
under 2s as immune system is not mature enough
under 3 months

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2
Q

3 things that make fever more worrying?

A
  • Fever that is more worrying = fever persisting fore more than five days, not feedy or drowsy
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3
Q

Why is it important to test for peripheral shutdown?

A

gives you an idea on whether this is a severe infection/ sepsis
should measure cap refill and feel temperature of the hands and feet
BP is not as helpful as this does not drop in children until very late

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4
Q

Fevers over what are more worrying?

A
  • More worried about fevers over 39.5 C
  • Except in children up to 3 months where fevers over 38C should be considered significant

should note the higher the temperature the more likely it is a serious cause but also this is all relative because some children are more prone to high temperatures

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5
Q

Describe the role of antipyretics when assessing fever?

A
  • Fever itself can raise the HR and RR so giving an antipyretic allows you to remove fever’s influence on HR and RR and see if it is still abnormal
  • Temperature dropping in response to an antipyretic is not a sign that infection is less serious, most fevers will drop
  • When giving an antipyretic you are looking for an up and down pattern – does the child perk up and is their RR and HR more normal
  • If RR and HR still abnormal and child is still drowsy or irritable when temperature is down this is much more worrying
  • How has child behaved when temperature brought down it anti-pyretic? An up and down pattern is reassuring. If give these medications they usually perk up
  • Children who are persistently drowsy or irritable even when temperature down is much more worrying
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6
Q

What is kawasaki disease?

A
  • This is an idiopathic self-limiting vasculitis that most often affects under 2s
  • The vasculitis affects small and medium sized arteries in multiple organs and tissues
  • Heart involvement is the most worrying as this can cause complications later on in life, can get myocarditis, coronary artery aneurysms, pericarditis and valvular disease
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7
Q

Who tends to get Kawasaki disease?

A
  • Cause unknown, potentially a reaction to a virus or autoimmune process
  • More common in children of Asian origin
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8
Q

Presentation of kawasaki disease?

A
  • CRASH and BURN
  • Conjunctivitis, rash (maculopapular then rash fades and get peeling of fingers and toes), adenopathy (particularly cervical), strawberry tongue, hand/ feet problems and burn = fever
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9
Q

Investigations for kawasaki disease?

A
  • No diagnostic test
  • Urinalysis may show sterile pyuria +- proteinuria
  • FBC in acute phase may show leukocytosis and neutrophilia
  • Raised ESR and CRP
  • Thrombocythemia may develop through weeks 2-3
  • LFTs may show elevated transaminases and bilirubin
  • Abdo ultrasound can show gallbladder distension
  • ECG can shown conduction abnormalities
  • Echo is essential as can reveal if there are cardiac complications e.g. aneurysms of coronary arteries
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10
Q

Management of kawasaki disease?

A
  • high dose Aspirin and intravenous immunoglobulin
  • Early treatment with IvIg reduces risk of cardiac complications
  • Generally, aspirin is not used in febrile children due to risk of Reye’s syndrome (rare syndrome that causes increased ICP and damage to liver) but in Kawasaki disease it is decided risk is worth benefit as it has antiplatelet and antipyretic effect
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11
Q

Most UTIs in children are caused by?

A

E. coli

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12
Q

In children under 3 months UTIs are more common in _____ over 3 months more common in ______

A

under 3 months more common in boys, after this more common in girls

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13
Q

Presentation of UTIs?

A
  • Often doesn’t present with typical UTI symptoms
  • If history and exam is not showing a focus for an infection you should start considering a UTI
  • In babies: vomiting, fever, lethargy, poor feeding, failure to thrive
  • In older children may complain of increased frequency and dysuria, may also have changes in continence, abdo or loin tenderness
  • 3-minute examination
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14
Q

Investigations for UTIs?

A
  • All infants with unexplained temperature of 38 or more should have their urine sent for microscopy and culture
  • Clean catch urine is recommended – can be difficult in those in nappies but essentially clean skin and remove nappy and wait and try and catch urine
  • When not possible may need catheter samples or suprapubic aspiration
  • Should also do a urine dipstick
  • Depending on child age, symptoms and if recurrent UTIs may want to do additional investigations to see if underlying cause e.g. Ultrasound
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15
Q

Management for UTIs?

A
  • Antibiotics – usually trimethoprim or nitrofurantoin
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16
Q

What is septic arthritis?

A
  • Infection of the joint
  • Can be caused by direct invasion, blood stream infection or less commonly from an infectious focus from cellulitis or spread from osteomyelitis
  • Occurs more often in children than adults
17
Q

Pathogens for septic arthritis?

A
  • Staph A
  • Streptococci
  • Only get staph epi if related to a prosthetic joint
  • Neisseria gonorrhoea if sexually active
18
Q

Presentation of septic arthritis?

A
  • Septic arthritis is a medical emergency
  • Joint is red, hot, painful and swollen, will be immobile
19
Q

Investigations for septic arthritis?

A
  • Aspirate joint and send fluid to micro, blood cultures, swabs, must check for crystals
20
Q

Management of septic arthritis?

A
  • Antibiotics – likely going to be flucloxacillin
21
Q

What are some serious causes of fever you need to rule out?

A

kawasaki disease
septic arthritis
meningitis
UTI
pneumonia and flu

22
Q

Pathogenesis of infective meningitis?

A
  • Microorganisms reach the meninges either by direct extension from the ears, nasopharynx, cranial injury, congenital meningeal defect or by blood stream spread
  • Strep pneumonia and Neisseria are by far the most common causes of meningitis
  • In neonates group B streptococcus is an important cause to remember
23
Q

Presentation of bacterial meningitis in children?

A
  • In meningococcal sepsis you get the classic appearance of the non-blanching rash
  • Fever
  • Vomiting
  • Constant headache
  • In Infants – bulging fontanelle
  • Older children – stiff neck, photophobia
  • Sleepy/ vacant/ difficult to wake
  • Confused/ delirious
  • Seizures
  • Fever (or hypothermia in small infants)
  • Rigors
  • Tachypnoea and Tachycardia
  • Pale or mottled skin
  • Cold hands and feet
  • Myalgia
24
Q

Investigations for suspected meningitis?

A
  • CRP and WBC (although be aware that normal results don’t rule out the diagnosis)
  • PCR tests from blood samples
  • Throat swab for culture
  • CSF sample from lumbar puncture can be done as a primary investigation unless contraindicated
25
Q

Treatment of meningitis in children?

A
  • Ceftriaxone (if penicillin allergic can give chloramphenicol) + dexamethasone just before or started with antibiotics
  • Cefotaxime may be given as a first dose before ceftriaxone or used instead in under 3 months
  • Under 3 months also receive amoxicillin
26
Q

In children presenting with fever that has lasted > 5 days name 4 key differentials to remember?

A
  • Stills disease / systemic JIA
  • Kawasaki disease
  • Rheumatic fever
  • Leukaemia
27
Q

In infants what two pulses do you check?

A

brachial or femoral