fibrinolytics and antifibrinolytics

Question 1

fibrinolytics

Answer 1

Fibrinolytics promote the degradation of thrombi by activating plasminogen to plasmin.
eg. Tissue plasminogen activator

Question 2

Tissue plasminogen activator

Answer 2

A serine protease found on endothelial cells of the blood vessels. Catalyzes the conversion of plasminogen to plasmin, which is the main enzyme responsible for clot breakdown. Recombinant tissue plasminogen activators (e.g., alteplase, reteplase, tenecteplase) are used as thrombolytics in patients with acute coronary syndrome, pulmonary embolism, or ischemic stroke.

Question 3

Recombinant plasminogen activators (rtPA)

Answer 3

tPAs that are produced by recombinant biotechnology techniques
Alteplase
Reteplase (rPA)
Tenecteplase (TNK-tPA)

Question 4

Streptokinase

Answer 4

enzyme produced by group A streptococci; catalyzes the conversion of plasminogen to plasmin

Question 5

Urokinase

Answer 5

serine protease found in plasma, urine, and various types of tissue that is also used in fibrinolytic therapy

Question 6

Antifibrinolytics

Answer 6

group of drugs that impair fibrinolysis, typically by interfering with plasmin formation
eg. TXA, aminocaproic acid