Final Flashcards
what virus causes Epstein Barr Virus?
HHV 4 (human herpes virus 4)
highest incidence of mono is in what age group
15-24 yo
incubation period of mono
30-50 days
highest morbidity in mono
college and military
EBV enters body thru
oral epithelial cell
mono infects what type of cell
B cells
mono causes the release of
cytokines
diagnostic test for mono
heterophile abs
sheep and horse cells
humoral immunity involves
extracellular microbes → bacteria
cellular immunity involves
cellular immunity → intracellular viruses
mono triad
fever
pharyngitis
posterior cervical LAD
mono often starts w.
malaise, HA, low grade fever
kissing tonsils
tonsillar exudates
palatal petechiae
splenomegaly
what type of drug causes rashes in mono pt
penicillins
penicillin induced rash in mono is characterized by
maculopapular
generalized
pruritic
less common findings in mono
+/- jaundice, periorbital edema, CNS findings, myocarditis
mono lab findings
lymphocytic leukocytosis:
absolute count > 4500
differential: >50% → inverted differential
atypical lymphocytes
increase of CD8+ T lymphocytes
Downey cell
what is an inverted differential
lymphocytes > neutrophils
what is a downey cell
reactive, atypical lymphocyte specific to viral infxn
the monospot test uses
heterophile abs
the monospot test is not always ___ or ___
specific; sensitive
how might mono affect LFTs
transient abnormal
ddx for mono
strep pharyngitis
CMV
toxoplasmosis
malignancy
peritonsillar abscess
malignancy
in strep pharyngitis, you will not see
splenomegaly
extreme fatigue
CMV is not is not _
and doe not involve _
exudative
splenomegaly




