Final Flashcards

1
Q

Indications

A

Reasons for giving a drug to a patient

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2
Q

Contraindications

A

Reasons for not giving a drug to a patient

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3
Q

Prescription (legend) drug

A

Drug that is regulated by the FDA due to having the ability to cause serious harm if not used in an appropriate manner

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4
Q

Conditions for valid VCPR

A
  1. Vet must assume responsibility for making clinical judgments
  2. Must have recently seen the animal and know its care
  3. Must be available for follow-up care
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5
Q

Regimen

A

Plan for administering drugs

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6
Q

Drug regimen consists of:

A

Kind of drug
Route of administration
Dosage
Frequency
Duration

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7
Q

Pharmacokinetics

A

Complex series of events that occurs once a drug is administered to the patient
Influences by the manner in which the drug is given
Some routes have limitations

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8
Q

Oral (PO)

A

By mouth
Contraindicated for animals with nausea/vomiting
Some taste horrible

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9
Q

Intravenous (IV)

A

Given in the vein
Takes effect almost immediately
Doesn’t last as long as drugs administered by other routes due to body eliminating drug rather quickly

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10
Q

Intramuscular (IM)

A

Given in the muscle
Sometimes painful
Absorbed more slowly than IV but faster than SQ

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11
Q

Subcutaneous (SQ or SC)

A

Given in tissue beneath the skin
Take longer to absorb than IV or IM

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12
Q

Intradermal (ID)

A

Given into the skin
Used for testing for allergies

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13
Q

Intraperitoneal (IP)

A

Given into the abdominal cavity

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14
Q

Intraarterial (IA)

A

An injection given into the artery

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15
Q

Intraarticular (IA)

A

An injection given into the joint

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16
Q

Intracardiac (IC)

A

An injection given into the heart
Used mostly for humane euthanasia and cardiopulmonary resuscitation (CPR)

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17
Q

Intramedullary

A

An injection given into the bone marrow cavity

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18
Q

Epidural/subdural

A

An injection given into the spine or near the spine

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19
Q

Nebulizer

A

Drug that can be inhaled in a fine mist
Antibiotics or bronchodilators can be inhaled into deep, small airways

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20
Q

Metered-dose inhaler

A

Administered by using a hand-held device that fits over an animal’s nose and mouth

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21
Q

Anesthetic gases

A

Gaseous forms given with vaporizers

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22
Q

Transdermal (topical)

A

Drugs that are placed on the skin
Gloves should always be worn when handling these drugs

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23
Q

Concentration Gradient

A

Drugs that move from one compartment of the body to another
Move from areas of high concentration to lower concentration

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24
Q

Bioavailability

A

Measures the amount of drug that gets absorbed and is available to the patient

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25
Water-soluble drugs
Dissolve in water Tend to stay in the bloodstream where they can be bound to various proteins (albumin) or can stay free
26
Lipid-soluble Drugs
Absorbed by bodily fats such as lipids Tend to move out of the bloodstream into the interstitial fluid Fat, liver, kidneys, and bone may act as storage sites for these drugs
27
What 2 body structures may interfere with the absorption of certain drugs
Placenta and blood-brain barrier
28
How are drugs excreted?
Removed primarily through the liver via bile or through the kidneys via urine May also be excreted through the mammary glands, the lungs, the GI tract, sweat glands, saline, or through the skin
29
Residues
Drugs that appear in the animal's milk or meat products Can cause allergic reactions in people, antibiotic resistance, and also cause some cancer in humans
30
Pharmacodynamics
Study of Mechanisms by which drugs produce physiological changes in the body Drugs combine with parts of the cell membrane or with internal parts of the cell to cause changes in how the cell functions Drugs may increase or decrease the activities of specific cells or tissues
31
Efficacy
The degree to which a drug produces its desired effect Once the efficacy level of a drug has been reached, giving more of the drug won’t produce more effect
32
Potency
the amount of drug needed to produce the desired effect and is represented by a dose on a dose-response curve
33
Lethal Dose (LD50)
the dose of the drug that’s lethal to 50% of the animals given that drug
34
Effective dose (ED50)
the dose of a drug that produces the desired effect in 50% of the animals given that drug
35
Therapeutic Index
LD50/ED50
36
Adverse Drug Reaction
Any undesired response to a drug
37
Formulary
A book that contains drug dosages and a listing of adverse reactions
38
Drugs are most commonly classified as __________ or _________
Proprietary (trade name of a patented drug) Generic (unpatented copy of a drug)
39
Drug labels on drugs must contain the following:
Drug names (both generic and trade names) Drug concentration and quantity Name and address of the manufacturer Controlled substance status Manufacturer’s control or lot number Drug expiration date
40
Environmental Protection Agency
Regulates the development and approval of animal topical pesticides
41
Drug Enforcement Agency
Concerned with the regulation of substances that have potential for human abuse
42
The DEA requires all those who dispense such drugs to be licensed and to keep careful records of all such drugs. Documentation should include the following:
Date of prescription Owner and patient name Drug name Amount dispensed and strength of the drug Initials of dispensing doctor
43
United States Department of Agriculture (USDA)
Regulates the development and appropriate biologics (medical products such as vaccines, serums, antitoxins,antibodies, and other products)
44
The Animal Medicinal Drug Use Clarification Act (AMDUCA)
made the extra label use of approved veterinary drugs legal under certain well-defined conditions This is an important law To get a drug labeled for a specific use in a specific animal costs a lot of money
45
List 6 Rights of Administration
Right patient Right drug Right dose Right route Right time and frequency Right documentation
46
Oral medications come in what forms
Tablets Suspensions Capsules
47
Emulsions
milky solutions containing the drug the mixtures don’t mix so it needs to be shaken
48
Elixirs
compound liquid medications held in solution by alcohol contains flavoring and sweeteners to help mask the taste of the drug
49
What ways can oral meds be administered?
Administering oral medications can be done with pill guns, a speculum (a tool placed inside a bodily cavity opening to insert a medicine), a stomach tube, syringes, or with your hands,
50
List 4 types of syringes
1. Slip tip – most common in vet med 2. Luer lock - have a screw top that secures the needle to the syringe, excellent for injecting thick fluids because they don’t allow the needle to separate from the syringe under pressure 3. Eccentric tip - used when injecting larger volumes (greater than 20 ml) into a vein, the hub of the syringe allows you to place a large syringe parallel to the vein you’re trying to inject 4. Catheter tip – good for oral feedings or for feeding with catheters
51
Uses of IV catheters
Good for repetitive IV meds and allows for repeated injections
52
Butterfly catheters
Used for short-term IV therapy
53
Endotracheal tubes
are placed into the trachea (tubes that air goes through towards the animal’s lungs) for controlled ventilation (such as with CPR) or for use with anesthesia machines
54
Tranquilizers
Used to calm or quiet a patient
55
Phenothiazine tranquilizers
Produce sedation without significant analgesia Ex. Acepromazine or chlorpromazine
56
Neuroleptanalgesics
Agents are a combination of an opioid and a tranquilizer They produce a state of reduced awareness and analgesia in which the patient may or may not remain conscious Useful for restraint, diagnostic procedures, as a preanesthetic, or for minor surgical procedures
57
Behavioral Pharmacotherapy
The use of drugs to treat various behavioral problems such as separation anxiety, phobias, compulsive disorders, or cognitive dysfunction syndrome Have to be combined with environmental and behavioral management
58
Anti-anxiety Medications
Help relieve anxiety in animals Side Effects: lethargy, ataxia, polyuria, polydipsia, hyperexcitability, and liver problems Ex. Diazepam, Alprazolam, Sileo
59
Antidepressant Medications
used in veterinary medicine to treat a variety of obsessive disorders and medical conditions by blocking reuptake (reuse) of norepinephrine and serotonin in the brain Side effects : sedation, tachycardia, mydriasis (overstretching of the eye’s pupil), dry mouth, urine retention, and constipation Ex. Amitriptyline, Trazodone, Fluoxetine, and Selegine
60
Serotonin-reuptake Inhibitors
Increase the amount of serotonin in the brain by preventing serotonin removal Side effects: anorexia, nausea, lethargy, anxiety, and diarrhea Ex. Fluoxetine
61
Monoamine oxidase-B inhibitors
Allow dopamine levels to increase and is used to treat old dog dementia and canine Cushing's Side Effects: vomiting, diarrhea, anorexia, restlessness, and shaking Ex. Selegiline
62
Inotropic Drugs
Affect the force/strength of a heart contraction Positive inotropic drugs improve the strength Ex. Dobutamine and Pimobendan Negative inotropic drugs decrease the strength
63
Chronotropic Drugs
Affects the heart rate Positive chronotropic increases the heart rate Ex. Atropine, dopamine, epinephrine Negative chronotropic decreases the heart rate Ex. Metoprolol and digoxin
64
Emetics
Drugs that cause vomiting Used in treatment of poisonings and drug overdoses Ex. Apomorphine, Xylazine, and Hydrogen Peroxide
65
Antiemetics
Drugs that help control or prevent vomiting Ex. Acepromazine, Metoclopramide, Meclizine, Ondansetron, and Maropitant citrate
66
Hematinics
Iron supplements that help correct anemia Ex. Iron supplements, androgens, and erythropoietin
67
Anticoagulant
Stop clot formation Ex. Heparin, EDTA
68
Laxatives
Medications that help stimulate bowel movements Ex. Lactose, Metamucil, Cat Lax
69
Antacids
Neutralize the stomach acid by binding directly to it which contains aluminum, calcium, and magnesium salts Ex. Ranitidine, Famotidine, omeprazole, sucralfate
70
Antitussives
Suppress or inhibit coughing Best for non-productive coughing Ex. Butorphanol, Hydrocodone Bitartrate, and Temaril-P
71
Expectorants
Thin mucous secretions to allow for easier expelling from the body Best for productive coughs Ex. Guaifenesin
72
Mucolytics
Decrease viscosity of mucus to help break it down Ex. Acetylcysteine
73
Decongestant
Eliminate or reduce swelling or congestion of nasal passages
74
Corticosteroids
Treat respiratory conditions due to allergies, most effective for treating equine COPD, can help feline asthma, helps inflammation controls signs/symptoms but not disease Ex. Dexamethasone and prednisone
75
Acetylcholine
a neurotransmitter that enables learning and memory and also triggers muscle contraction
76
Anticholinergics
Decrease GI motility, dry secretions, dilate pupils, and prevent/treat bradycardia Ex. Atropine and Aminopentamide
77
Adrenergic agents
stimulate heart beats, correct hypotension, cause vasodilation, treat urinary incontinence Ex. Dopamine, Epinephrine, Norepinephrine
78
Glaucoma Adrenergic Agents
Antagonists for adrenergic agents (reversal) Treat urethra obstruction Cause vasodilation
79
Barbiturates
Depress the CNS Useful as a sedative, anticonvulsant, general anesthetic, and euthanasia agent Ex. Phenobarbital, pentobarbital
80
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Large group of drugs that provide mild pain relief and anti-inflammatory benefits for conditions such as arthritis Ex. Carprofen, Deracoxib, Meloxicam, Robenacoxib, and Grapiprant Side Effects: GI bleeding and ulcers
81
Synthetic Progestins
Used to treat behavioral problems associated with changing hormonal levels. They’re used in animals for aggression between males, spraying or marking problems, and dominance aggression
82
Euthanasia Agents
These agents are used to relieve suffering by ending the animal’s life. Such deaths put an end to hopeless medical situations in a humane fashion. These drugs rapidly produce unconsciousness without struggling or excessive involuntary movement Ex. Pentobarbital sodium (Fatal-Plus, Somnasol, and Euthasol)
83
Antidiuretic Hormones
These drugs are used to treat diabetes insipidus. Patients that have diabetes insipidus don’t secrete a normal amount of antidiuretic hormone (ADH). These patients pass a lot of highly diluted urine (urine that doesn’t contain the right amount of chemicals) and are abnormally thirsty. Lifelong therapy is usually needed. Ex. Vasopressin
84
Urinary Acidifiers
These drugs are used to lower the pH of urine. Lower urine pH discourages the formation of certain urinary crystals or stones. Some crystals form in alkaline urine, so making the urine acidic (by lowering its pH) helps keep them in dissolved form. Often the diet needs to be changed as well to help stop the production of crystals or stones. You can test the animal’s urine pH with test strips, an effective way to monitor the animal’s response to therapy. Ex. methionine and ammonium chloride
85
Urinary alkalizers
Are used to raise the pH of urine to discourage the formation of urinary stones that form in acid urine (such as urate, calcium oxalate, and cystine stones or crystals) Ex. Potassium citrate and sodium bicarbonate
86
Urinary Incontinence
The inability of the animal to urinate on demand. The animal can’t urinate at all or urinates uncontrollably. Nerve damage and hormonal imbalance are the two most common conditions associated with urinary incontinence Ex. Estradiol and Phenylpropanolamine (PPA)-Proin
87
Glycosaminoglycans (GAGs)
Help to manage interstitial cystitis by preventing microorganisms and crystals from sticking to the wall of the bladder
88
Epakitin
Extracted from shells of crabs and shrimp. Binds phosphorus in the intestine, helping to eliminate the high blood phosphorus levels often seen in pets with renal failure.
89
Catecholamines
Act by stimulating the sympathetic nervous system to: Increase the force and rate of heart contractions Constrict peripheral blood vessels (which increases blood pressure) Elevate blood glucose levels Side Effects: tachycardia, dyspnea, and wide ranges of blood pressure changes Ex. Dopamine, epinephrine, and norepinephrine
90
Bipyridine Derivatives
Work by inhibiting enzymes that lead to an increase in cellular calcium Ex. Amrinone and milrinone
91
Surfactants
Reduce water surface tension, which allows water to penetrate into and soften the contents of the gastrointestinal tract Ex. Pet-Enema
92
Protectants/Adsorbents
Protectants- Coat the intestines and relieve inflammation Adsorbents- Bind with bacteria or toxins to protect against harmful effects Ex. Activated charcoal
93
Antifoaming Agents
Used in ruminate to prevent gas bloating They are surfactants that change the surface tension of the bubbles and cause them to break down so they can be expelled through the stomach tube Ex. Bloat Guard
94
Anti-inflammatory Drugs Role in GI Tract
Decrease inflammation in the intestinal walls in cases of idiopathic IBD Ex. Prednisone and Sulfasalazine
95
GI Prokinetics/Stimulants
Increase the motility of part of the gastrointestinal system to increase the speed of materials through the tract Ex. Metoclopramide, cisapride, and Ranitidine
96
Bulk-producing Agents
Absorb water and swell to increase the bulk of intestinal contents to stimulate peristalsis Ex. Metamucil
97
Purpose of a fecal float
Helps to find intestinal parasites
98
Prostaglandin E-1 Analogs
Are used to decrease stomach acid production (at high doses), to protect the stomach lining (at low doses), and to prevent or treat gastric ulcers associated with the use of NSAIDs Ex. Misoprostol
99
List main endocrine glands
Pituitary gland Adrenal gland Thyroid gland Ovaries and testicles Pancreas Kidneys
100
Gonadorelins
Cause animals to produce FSH and LG Induces estrus is horses and cats Treats cystic ovaries in dairy cattle
101
Follicle-stimulating hormone
Stimulates ovaries to produce more follicles than normal
102
Estrogens
Inhibit ovulation, increase uterine tone, and are used to treat persistent corpus luteums in cattle Ex. Estradiol
103
Androgens
Male sex hormones that help promote weight gain, red blood cell formation, and tissue anabolism (or growth). These drugs can be used to help prevent estrus in female dogs Ex. Testosterone
104
Progestins
Help maintain pregnancy Have same effect as progesterone
105
Thyroid Gland
Located in the neck and convert iodine into 2 active hormones(T3 and T4) Involved with many body processes including HR, body temp, metabolic rate, metabolism, and skin condition
106
Hypothyroidism
Thyroid gland producing too much thyroid hormone Most cases are dogs Symptoms: fast HR, lose weight despite eating, and may be hyperexcitable Medications: Levothyroxine
107
Hyperthyroidism
Thyroid gland producing too little thyroid hormone Most cases are older cats Symptoms: lethargic, afflicted with poor skin and hair coat conditions, often bradycardic Medications: Methimazole
108
Hypoadrenocorticism (Addison's Disease)
Adrenal gland is unable to produce aldosterone and glucocorticoids needed to sustain life Symptoms: weakness, collapse, and diarrhea
109
Hyperadrenocorticism (Cushing's Disease)
Oversecretion of aldosterone and glucocorticoids by the adrenal gland Common in dogs and horses Medications: Trilostane
110
Ophthalmic Drugs
Help treat eye problems
111
Schirmer Tear Test
Measures the amount of tears produced by the lacrimal (tear) glands
112
Fluorescein Stain
Checks for corneal scratches and ulcers
113
Rose Bengal
Stain used to detect corneal damage due to viruses or low tear production
114
Topical Anesthetic Drops
Can be used to numb the eye to check for and remove a foreign body from the eye Ex. Proparacaine and Tetracaine
115
Povidone Iodine Solution
When diluted, it can be used as an antiseptic to remove dirt and debris from an eye and to clean the surface during an ophthalmic exam
116
Mydriatics
Agents used to dilate the pupils Ex. Tropicamide
117
Miotics
Used to constrict the pupils Help treat glaucoma Ex. Pilocarpine
118
Carbonic Anhydrase Inhibitors
Lower the production of the aqueous humor which lowers the pressure of the eye Treat open-angle glaucoma Ex. Acetazolamide
119
Tonometer
An instrument used to measure eye pressure
120
Otic drugs
Help treat ear problems
121
Dermatophyte Test
Include fungal cultures, exams using Wood's lamp, and microscopic exams of the hair and follicle
122
List the functions of the skin
Protection Temp regulation Storage Sensory perception Secretion Vitamin D production and metabolism
123
Seborrhea
Skin condition that results in an increased amount of scaling
124
Keratolytic
Agent that promotes loosening of the epidermis to help remove scaling
125
Astringents
Applied to help precipitate proteins and are used on areas of moist dermatitis
126
Antiseptic
Agent used to help inhibit the growth of bacteria on the skin Used to clean wounds and prepare areas of the body for surgery
127
Antipruritic
Anti-itch medicine
128
Zoonotic
Disease from an animal that can passed to humans
129
List the 4 Stages of Wound Healing
Stage 1: damaged cells release substances that cause inflammation and decrease bleeding causing blood vessels to constrict, serum leaks into wound and fibrin helps clotting of the blood to seal up the wound Stage 2: white blood cells move into the area to help clear up the infection and remove dead material Stage 3: fibroblasts, cells that produce fiber, begin to move through the area, producing collagen which, in combination with new capillaries, forms granulation tissue (scar tissue) Stage 4: remodeling occurs and the first 3 stages are cleaned up and the healed area becomes stronger
130
Elizabethan Collar
Helps prevent the animal from licking the wound
131
Caustic agents
Burn away or eat dead flesh
132
Microorganisms
Can only be seen with a microscope Ex. Fungi, bacteria, viruses, protozoa)
133
Gram Stain Test
Help classify bacteria Gram Positive- Stains and turns blue Gram Negative- Doesn’t stain and stays red
133
Acid Fast Stain
Help classify bacteria that doesn’t stain with gram tests If they retain the stain during this test then they are acid fast bacteria
134
Aerobic bacteria
Can live in only oxygenated environments
135
Anaerobic bacteria
Persist in oxygen-free environments
136
Antibiotics
Drugs that are used to inhibit the growth of bacteria(bacteriostatic) or to kill bacteria(bactericidal)
137
Fungal infections are divided into _______ and _______
Superficial (skin and eyes) Systemic (blood, lungs, CNS)
138
Antifungal Medicines
Being researched No widespread use in vet medicine
139
Cultural Sensitivity Test
Test used to find out which antibiotics inhibit the growth of bacteria in that culture and helps the vet choose the right antibiotic
140
What helps prevent nosocomial infections in patients?
Disinfectants- kill microorganisms or inactivate viruses on inanimate objects Antiseptics- kill microorganisms on living tissues
141
Parasites
organisms that live off a host by deriving nutrients and home from their host Ectoparasites - parasites that live on a host Endoparasites - parasites that live in a host
142
Parasitiasis
Animal is infected with no clinical signs
143
Parasitosis
Animal is infected with clinical signs
144
Anthelmintic
Drug used to eliminate helminth (intestinal) parasites
145
Anticestodal
Used to treat tapeworms
146
Antitrematodal
Used to remove flukes
147
Antiprotozoal
Used to treat protozoa (coccidia and giardia) which cause diarrhea in most species
148
List the indirect signs of pain in a dog:
Abnormal body position, movements, or limping Increased heart rate Increased breathing rate Decreased appetite Salivation Vocalization Tenderness Restlessness
149
Mineralocorticoid
Help regulate electrolyte and water balance in the body
150
List the signs of dehydration:
Vomiting Diarrhea Lack of desire to drink Mucous membranes that feel dry and tacky Skin that doesn’t return to normal when pulled (using the skin turgor test) Weak or unsteady pulse
151
Macrodrip
Typical sets give 10 drops, 15 drops, and 20 drops per mL
152
Microdrip
Typical set gives 60 drops per mL
153
List the fat-soluble vitamins and precautions with them
A, D, E, and K Don't get removed from the body with increased fluids
154
Vitamin A
Promotes growth and adequate visual pigment in eyes
155
Vitamin D
Growth and regulation of calcium levels
156
Vitamin E
Acts as an antioxidant Too little causes muscle diseases
157
Vitamin K
Helps with clotting process Can work as an antidote to rat poison ingestion
158
Immunosuppressive Agents
Drugs used to treat immune-mediated disorders
159
Autoimmune Disease
Disease in which the body's immune system attacks itself
160
Inactivated (killed) Vaccine
Usually very safe, last in storage, and are unlikely to cause the disease itself. Inactivated vaccines contain organisms or bits of organisms that are killed. Unfortunately, killed vaccines usually don’t give a strong immune response, need to be repeated, and sometimes contain preservatives that can cause allergic reaction
161
Live Vaccine
Made from living bacteria or viruses which may be virulent (able to cause disease) or avirulent (not able to cause disease), cheaper, require fewer doses, stimulate the immune system more vigorously
162
Modified Live Vaccines
Take the live organism and process it to remove the organism's virulence
163
Recombinant Vaccine
Made by modifying the DNA of the organisms in various ways to produce vaccines
164
Core Vaccines
Basic vaccines recommended for all animals Protect animals from common contagious diseases
165
Noncore Vaccines
Recommended based on risk factors such as where the animal lives and their way of life
166
Toxoid
Vaccine used to produce immunity to a toxin rather to a bacterium virus
167
List signs of a vaccine reaction
Vomiting Salivation Dyspnea Hives (skin blotches, redness, swelling) Lack of coordination Swelling of the face or the muscles
168
Regenerative Medicine
the use of cells and growth factors to improve the repair of damaged or poorly functioning tissues or organs, usually orthopedic disorders
169
Nutraceuticals
Food components that have health benefits, including disease prevention and treatment. Nutraceuticals don’t undergo testing by the FDA for safety or efficacy. Nutraceutical labels are required to have a label that says, “This statement has not been evaluated by the Food and Drug Administration. This product isn’t intended to diagnose, treat, cure, or prevent any disease."
170
Chondroprotective
Help to slow down the erosion of cartilage (tissue surrounding the bones) in animals. They don’t heal cartilage or regenerate it and are best used before the onset of arthritis Ex. Adequan, Cosequin, and Dasuquin
171
Herbal Medicine
Use of plants to treat disease Plant material may be available dried, powdered, capsules or granules, or formulated into an ointment or as a liquid extract Ex. Ginger for anti-inflammatory effects Aloe vera to treat burns and wounds Milk thistle to support and heal the liver
172
Lubricants
Used for gynecologic and rectal exams Should be water-soluble to help with the cleaning of instruments
173
Explain the importance of inventory control
From a legal standpoint, the correct completion of DEA forms is essential. Verifying that invoices from vendors match the prices and quantities your practice ordered and received is also vital. Having the right supplies on hand when needed can make a life-or-death difference for your animal patients and can assure the smooth flow of caregiving that makes your practice an enjoyable and rewarding place to work.
174
Triage
Means making an evaluation and choosing the most injured or critically ill patient to be seen first
175
List items contained in a crash cart
various sizes of endotracheal tubes, gloves, tape, gauze, scissors, IV catheters, fluids, urinary catheters, monitors, bandage material, Ambu-bag (to inflate a patient’s lungs), stethoscope, syringes, needles, blood tubes, and other laboratory supplies
176
List responsibilities of vet techs in emergency procedures
CPR IV cath placement Drug administration