FINAL

Question 1

Signal 3 cytokines

Answer 1

IL12, IL4, IL6, TGF-B

Question 2

TH1 differentation is stimulated by what

Answer 2

IL12

Question 3

What cytokines does TH1 produce

Answer 3

IL2, IFN-gamma, TNF-alpha

Question 4

Functions of TH1

Answer 4

activate macrophages –> enhanced phagocytosis–granuloma formation
activate cytotoxic lymphocytes
help b cells produce ab
inhibit TH2

Question 5

TH2 differentation is stimulated by

Answer 5

IL-4

Question 6

What cytokines does TH2 produce

Answer 6

IL-4, IL-5, IL-13

Question 7

Functions of TH2

Answer 7

produce eosinophils and mast cells
inhibit TH1

Question 8

TH17 differenation is stimulated by

Answer 8

IL6 and TGF-Beta

Question 9

What cytokines does TH17 produce

Answer 9

IL-17, IL-22

Question 10

functions of TH17

Answer 10

neutrophilic response
barrier tissue defense

Question 11

Effector function of IL-2

Answer 11

Proliferation of T cell –> Activation of NK cells

Question 12

effector function of IFN-gamma

Answer 12

polarization of macrophages (M1) –> activated CD8+ T cell

Question 13

How do TH1 cells activate macrophages

Answer 13

Via IFN-gamma and CD40 ligand signaling

Question 14

Effector function of TNF-alpha

Answer 14

Activation of endothelia –> Apoptosis of infected cell

Question 15

Effector Function of IL4

Answer 15

B Cells (IgE and IgG4production)

from TH2 cell

Question 16

Effector function of IL5

Answer 16

eosinophils – degranulation – parasitic destruction

Question 17

Effector function of IL13

Answer 17

synergizes with IL4 – polarization of M2 – promote wound healing

Question 18

Effector Function of IL17

Answer 18

IL6, IL8 – inflammation
G-CSF – neutrophil numbers

Question 19

Effector functions of IL22

Answer 19

antimicrobial peptides (Beta defensins)
Proliferation and ECM production

Question 20

CTL release what cytotoxins to induce apoptosis

Answer 20

perforin and granzyme

Question 21

CTL ligation of death receptors

Answer 21

Fas ligand binds Fas (receptor)

Question 22

What could outcompete Caspase-8 binding to FADD and block apoptosis

Answer 22

c-FLIP which can also block TNF-alpha mediated apoptosis

Question 23

What cytokine can drive expression of Fas and FasL expression on activated T cells

Answer 23

IL2

Question 24

O Malt vs D Malt

Answer 24

O = inductive – where immune response is induced
D = effector site – ab are secreted

Question 25

# INNATE IMMUNITY membrane bound mucin molecules combined with glycolipids = thick layer which provides physical barrier that prevents microbes from contact with epithelial layer

Answer 25

Glycocalyx

Question 26

what are the main **antimicrobial peptides** in the **small intestine** called

Answer 26

**a-defensins** produced by Paneth cells | large intestine = B-defensins

Question 27

these proteins block bacterial colonization of the mucosal epithelial surgace have bactericidal effects against G+ bacteria

Answer 27

REG III lectin proteins regenerating islet derived proteins | released via paneth cells

Question 28

peyers patch lies beneath

Answer 28

Follicle associated epithelium

Question 29

what cells allow antigens to enter the peyers patch via transcytosis

Answer 29

M CELLS = part of FAE