FINAL Flashcards

1
Q

Major Depression Disorder

A

-5+ in 2 week period:

-DEPRESSED MOOD or LOSS OF INTEREST OR PLEASURE
-Depressed most of the day, nearly every day
-anhedonia
-weight loss when not dieting or weight gain (> 5% in a month), or decrease or increase in appetite
-Insomnia or hypersonic
-Psychomotor agitation or retardation (observable by OTHERS)
-Fatigue
-worthlessness or guilt
-bad concentration, or indecisiveness
-suicidal ideation
-impairment in social, occupational, or other important areas of functioning.
-not attributable substance or medical condition

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2
Q

depression pharmacotherapy

A

-SSRIs (Prozac): Inhibit the reuptake of Serotonin.
-SE: Insomnia, sedation, agitation, GI upset, headache, !decreased libido, erectile dysfunction, anorgasmia!

-SNRIs (Effexor): Inhibit the reuptake of Serotonin and Norepinephrine.
-SE: Insomnia, anxiety, hypertension, headache, decreased libido, erectile dysfunction, and anorgasmia, lowers threshhold for seizures, less ED

-NDRIs (Wellbutrin): Inhibit reuptake of dopamine and norepinephrine
SE: Decreased seizure threshold, headache, insomnia, agitation, tachycardia, dizziness, less ED
-!Fewer sexual side effects!

-Off-Label and Adjunctive Drugs:
-Antipsychotics: added in resistant or psychotic depression

-Antiepileptics: resistant or agitated depression
-Phenytoin, ethosuximide, carbamazepine, oxcarbazepine, gabapentin, sodium valproate, pregabalin and lamotrigine

-Lithium: adjunct in resistant depression

-Psychostimulants: improve effectiveness of antidepressants in resistant depression while specifically targeting sadness, anhodenia, decreased energy, and decreased cognition.
-ex. ritalin, Adderall

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3
Q

mania symptom domains

A

-Elation: Euphoria, grandiosity, pressured speech, impulsivity, increased libido, recklessness, social intrusiveness, decreased need for sleep

-Dysphoria: Depression, anxiety, hostility, irritability, suicide, violence

-Cognition: Racing thoughts, distractibility, disorganization, inattentiveness

-Psychotic: Delusions, hallucinations

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4
Q

bipolar disorder tx

A

-ANTIMANIACS
-lithium - DOC
-SE: Hypothyroidism, tremor, thirst, polyuria, GI distress, arrhythmia, leukocytosis
-Teratogenic in first trimester
-Narrow therapeutic index
-Initial Labs: CBC, U/A, BUN/Creatinine, HCG Electrolytes, Thyroid Functions, EKG

-ANTIEPILEPTICS
-Depakote (divalproex sodium, valproate)
-SE: Headache, GI upset, tremor, elevated LFTs. thrombocytopenia, hepatotoxicity
-Initial Labs: CBC, LFTs, HCG

-Equetro/Tegretol (carbamazepine)
-SE: Sedation, GI upset, elevated LFTs. leukopenia, thrombocytopenia, aplastic anemia
-Initial Labs: CBC, LFTs, HCG

-Lamictal (lamotrigine)
-SE: Exfoliating dermatitis, Stevens-Johnson Syndrome, dizziness, ataxia, sleepiness
-Initial Labs: N/A

-ANTIPSYCHOTICS
-All atypical antipsychotics are FDA approved
-SE: lethargy, somnolence, dry mouth, wt gain, and orthostatic hypotension
-parkinson-like symptoms.

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5
Q

anxiety

A

-MC mental health illness in USA
-PCP treats 90% of time
-high rate comorbid psychiatric disorder -> Depression (50%)
-High rates of alcohol and drug abuse
-high rates of suicide attempts
-5X more likely to see medical care
-6X more likely to be hospitalized for a psychiatric condition
-Affects 1/8 children -> strong genetic component

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6
Q

Generalized Anxiety Disorder

A

-6 MONTHS 3+ -> only 1+ in children:

-edginess or restlessness
-tiring easily, more fatigued than usual
-impaired concentration / mind goes blank
-irritability
-increased muscle aches or soreness
-difficulty sleeping (trouble falling asleep, staying asleep, restlessness at night, unsatisfying sleep)

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7
Q

social anxiety

A

-6 months
-affecting either interpersonal or occupational functioning

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8
Q

phobic disorder

A

-6 months
-rule out -> agoraphobia, OCD, separation anxiety
-animal, natural environment, blood-injection, situational

-agoraphobia- 6 months

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9
Q

PTSD

A

-Criterion A: Exposure to death, threatened death, serious injury, or sexual violence in 1+ of following:
-Direct experience
-Witnessing first hand
-Learning relative/friend was exposed to trauma
-Repeated or exposure to details of trauma -> first responders, medics, police officers

-Criterion B: Presence of 1+ INTRUSIVE symptoms:
-Recurrent distressing memories
-Recurring nightmares
-Flashbacks
-Intense distress with reminders
-Physical reactions with reminders

-Criterion C: AVOIDANCE 1+ of following:
-Avoidance of distressing memories
-Avoidance of external reminders, like people, places, conversations, and activities

-Criterion D: Negative alterations to mood and cognition, 2+ of following:
-cant remember aspects of trauma
-negative thoughts about oneself, others, or the world
-Blaming oneself or others for the trauma
-Persistence negative emotional state -> fear, horror, anger, guilt, or shame
-Diminished interest
-detachment or estrangement from others
-Inability to experience positive emotions

-Criterion E: REACTIVITY, 2+ of following:
-Irritability and angry outbursts
-Reckless and self-destructive behavior
-Hypervigilance- constantly assessing threats
-Exaggerated startle response
-Problems with concentration
-Difficulty sleeping

-Criterion F: > 1 month

-Criterion G: impairment in social, occupational, and other important areas of functioning.

-Criterion H: not due to medication, substance use, or another medical condition

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10
Q

OCD related disorders

A

-trichotillomania
-body dysmorphic disorder
-hoarding disorder
-excoriation disorder

-obsessions:
-contamination
-pathologic doubt
-need for symmetry
-scrupulous
-aggressive/violent
-sexual

-compulsions:
-cleanings
-checking, arranging
-congessing
-counting
-praying

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11
Q

drugs that cause anxiety

A

-social- alcohol, caffeine, nicotine
-prescription drugs- corticosteroids, beta agonist, theophylline, methylphenidate
-OTC drugs- decongestants
-illicit drugs- cocaine, amphetamine, marijuana, LSD, K2
-drug withdrawal- alcohol, caffeine, nicotine, benzodiazepines, beta blockers, heroin, pain meds

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12
Q

anxiety tx: pharmacotherapy

A

-SSRIs (Prozac, Lexapro): 1st Line Tx!!
-Starting dose lower than Depression -> SE are more common compared to Depression
-Therapeutic dose often higher compared to Depression

-SNRIS (Effexor XR, Pristiq, Cymbalta): Indicated in Anxiety and Depression

-Tricyclic Antidepressants: Anafranil indicated for OCD

-Serotonin Partial Agonists (BuSpar): Indicated for GAD only
-No tolerance, dependence, withdrawal, and sedation

-Benzodiazepines: Not first-line tx, but -> immediate onset.
-SE: Sedation, confusion, impaired memory, ataxia, behavioral disinhibition, respiratory depression, tolerance, dependence, withdrawal
-death -> in pts with impaired respiratory function (COPD, Sleep Apnea)

-Antihypertensives:
-Alpha-2 Agonists (Clonidine): Reduces sympathetic activity
-Beta-blockers (Inderal) Decrease autonomic response

-Anticonvulsants (Neurontin, Lyrica): Increase GABA levels in the brain

-Antipsychotics (Risperdal, Geodon): Decrease dopamine in brain
-Block Serotonin-2 pathways in the brain

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13
Q

personality disorder

A

-A. behavior deviates from expectations of pts culture
-2 of following:
-cognition (perception and interpretation of self, others and events)
-affect (range, intensity, lability, and appropriateness of emotional response)
-interpersonal functioning
-impulse control

-B. inflexible across social situations.
-C. impairment in social, occupational, or other
-D. long duration and onset traced back to adolescence or early adulthood

dx- Minnesota Multiphasic Personality Inventory

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14
Q

paranoid personality etiology

A

-MC in families with hx of schizophrenia or delusional disorder
-MC in pts whos family emphasized avoiding scrutiny and failure
-MC in people who suffer mistreatment -> prisoners, refugees, war victims

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15
Q

schizoid etiology

A

-in families with autism and schizophrenia
-defense mechanism to avoid emotional distress from repeated failures in past
-slightly MC in pts with no family emotional nuturing

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16
Q

antisocial personality / etiology

A

-impulsive -> dont plan ahead
-irresponsible

-5x more likely in pts with 1st degree male with ASPD
-increase risk if father is alcoholic
-twin studies show correlation
-Lack of consistent person for child to bond with
-Neglect and physical abuse in childhood noted.

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17
Q

borderline personality

A

-sees things are good or bad

-increased in pts with 1st degree relative who have substance abuse or mood disorders
-raised in invalidating environment
-neglect and childhood sexual, physical, or emotional abuse
-conflict with maternal figure noted in childhood

-impulsivity gets better past 30 but interpersonal problems persist
-67%- substance abuse
-50% depression
-10% suicide

-dialectical behavior therapy (DBT)

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18
Q

narcissistic etiology

A

-child remains self centered due to lack of empathy from parents
-reaction to combat low self esteem secondary to lack of parental appreciation

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19
Q

avoidant personality etiology

A

-parental rejection or not enough early love
-pt never took personal risks to realize failing is not fatal

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20
Q

obsessive compulsive personality etiology

A

-parental reinforcement of conformity
-harsh discipline
-compensation for lack of control in other areas of life

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21
Q

anorexia

A

-significantly low body wt compared to expected wt with age, sex, development
-BMI < 17.5 or <85% of expected
-dependent edema
-cardiac arrhythmias- tachy, brady
-bloating
-appetite REMAINS
-ritualistic exercise
-3 MONTHS

-labs:
-leukopenia
-hypoglycemia
-hypokalemia, hypochloremia
-metabolic alkalosis
-EKG- ST depression, T wave flattening/inversion, prolonged QTC

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22
Q

bulimia

A

-1x week for 3 months
-high calories, sweet, smooth texture
-50% anorexics become bulimic (hard to not eat)
-russels sign
-malnutrition not obvious

-impulse control problems
-many are borderline

-dehydration
-low Mg, hypokalemia, hypochloremia (metabolic alkalosis)
-gastric ulcers
-esophageal tears
-esophageal cancer
-bradycardia, hypotension

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23
Q

eating disorders tx

A

-hospitalize- when death is likely:
-malnutrition
-dehydration
-electrolyte imbalance
-20% < expected wt
-30% < expected wt -> long term care

-daily wt
-in and outs
-small meals 500 cals over maintenance cals
-bathroom observation
-stool softeners - NOT lax
-+/- reinforcement
-CBT- 1st line for BN, meds, education
-higher dose SSRI

24
Q

binge eater

A

-never becomes AN
-psychiatric comorbidity- self injury, sexual abuse
-most remit within 5 years
-1x week for 3 months

25
ADHD
-Inattention -6+ < 16yo -5+ >17yo -6 months: -no close attention to details -> careless mistakes -cant hold attention on tasks -doesnt listen when spoken to -doesnt follow through on instructions and fails to finish schoolwork, chores, or duties in the workplace (e.g., loses focus, side-tracked). -organizing tasks and activities. -avoids tasks that require mental effort over a long time -loses things -easily distracted -forgetful in daily activities. -Hyperactivity and Impulsivity: -6+ < 16 years -5+ >17 yo -6 months -fidgets; taps hands or feet, or squirms -leaves seat -runs about or climbs -unable to play quietly. -“on the go” - motor” -talks excessively. -blurts out -trouble waiting their turn. -interrupts or intrudes on others -Cause: Decreased dopamine in frontal lobe -> decreased arousal!
26
autism
-poor social-emotional reciprocity, ex. abnormal back-and-forth -> reduced sharing of interest -> failure to initiate social interactions. -poor nonverbal communication -poor development, maintaining, and understanding relationships, ex. appropriate behavior per situation -> to difficulties in imagination -> absence of interest in peers -at least 2: -Stereotyped or repetitive motor movements, use of objects, or speech (motor stereotypes, lining up toys or flipping objects, echolalia, idiosyncratic phrases) -adherence to routines, ritualize patterns -Highly restricted, fixated interests that are abnormal in intensity or focus -Hyper- or hyporeactivity to sensory input (indifference to pain/temperature, adverse response to specific sounds or textures, excessive smelling or touching of objects, visual fascination with lights or movement) -based on social communication problems and repetitive patterns of behavior
27
conduct disorder
-4+: -Aggressive toward people/animals -physical altercations with others -Use of a weapon -physically cruel to people -cruel to animals -forcible sex act on another -Property destruction by arson -Property destruction -economic crime; ex. breaking and entering -confrontational economic crime- ex. mugging -theft; ex. shoplifting -broke curfew before 13yo -run away at least 2 times -Truant before 13yo! -impairment in functioning - < 18 yo
28
oppositional defiant disorder
-6 months -4 + -loses temper -touchy or easily annoyed -angry and resentful. Argumentative/Defiant Behavior -argues with authority figures -> for children, with adults -refuses to comply with authority figures or rules -deliberately annoys others -blames others -spiteful or vindictive > 2x within 6 months -<18yo
29
somatoform disorder
-Excessive thoughts/behaviors of somatic symptoms -1+, 6 months: -thoughts about seriousness of symptoms. -anxiety about health or symptoms. -time and energy to symptoms or health concerns. -1 somatic symptom may not be present, but being symptomatic is persistent (typically more than 6 months) -physical symptoms with no pathology -1. conversion- extreme stressor -> neurological loss -la belle indifference- pt appears less concerned with disability than expected -2. hypochondriasis -3. body dysmorphic disorder -4. factitious disorder -5. malingering
30
schizophrenia
-heritability estimated between .60 and .90 -Emil Kraepelin- dementia -Eugene Bleuler- 1911- schizophrenia -Kurt Schneider- delusions, hallucination -> first rank symptoms -Tx in1950s- thorazine (chlorpromazine) -increase dopamine in limbic and decrease in frontal cortex -10 year period- 15% recover, 30% live independently, 30% require extensive help, 15% dont improve at all, and 10% suicide -each recurrence -> increase impairment -1. delusions -2. hallucinations -3. disorganized speech -disorganized or catatonic behavior -negative symptoms -impairment in work, interpersonal, or self relationships -6 months with at least 1 month with active symptoms -r/o schizoaffective disorder
31
schizophrenia symptoms
-delusions- grandiose, paranoid, somatic (bodily abnormality, illness, special attribute) -bizarre or non-bizarre -hallucinations- derogatory, command -disorganized speech/thought -disorganized/bizarre behavior- inappropriate out of context -ex. pt covering self in feces, undressing in class -negative symptoms- anhedonia, asociality, affect -avolition- no interest in routine activity -alogia- no speech
32
schizophrenia: disorganized thought/speech
-Clanging: Rhyming of words -I heard the bell. Well, hell, then I fell. -Flight of Ideas: Sequence of loose associations -> speaker jumps to unrelated topic -I own five cigars. I’ve been to Havana. She rose out of the water, in a bikini. -Neologisms: Made up words -I got so angry I picked up a dish and threw it at the geshinker.“ -Word Salad: Nonsensical use of words -Because it makes a twirl in life, my box is broken help me blue elephant. Isn’t lettuce brave? I like electrons, hello please! -Loose Associations: Connections between thoughts are very weak -He went to the ballpark and bought Frank’s beer belly home in a bag of grass seed. -Incoherence: no connections between thoughts -Blue afraid you no carpet cat got fear bricks of orderly mess.
33
stages of schizophrenia
-1) Prodrome: Gradual onset of behavioral disturbances, social withdrawal, academic decline -irritable, suspicious, disorganized, obsessed with odd hobbies or the occult. -2) Acute: Clinically significant signs and symptoms, causing great distress -May be episodic with transient remissions or chronic. -3) Residual: Negative symptoms predominate. Appears withdrawn, preoccupied, flat or depressed. Impoverished speech and poor cognition.
34
first generation antipsychotics
-Dopamine antagonists -Haldol! (haloperidol!), Loxitane (loxapine), Mellaril (thioridazine) -MOA- strong affinity for dopamine receptors -decrease positive symptoms -negative symptoms - probably worsened -SE: -dystonia, EPS's, targive dyskinesia (contortions), prolactinemia -neuroleptic malignant syndrome- fever, muscle rigidity, AMS
35
2nd generation antipsychotics
-Dopamine/Serotonin antagonists -Olanzipine (Zyprexa), Quetiapine (Seroquel), Risperidone (Risperdal) -MOA- weak dopamine blocker, strong serotonin blocker -positive symptoms- decrease -negative symptoms- possible decrease -Side Effects: Decreased Dystonia, EPS’s, Tardive Dyskinesia, Prolactinemia -much less side effects
36
3rd generation antipsychotics
-Dopamine partial agonist (agonist/antagonist) -Abilify (Aripripazone), Geodon (Ziprasidone) -MOA- decrease dopamine where too high and increase dopamine where too low -positive symptoms- decrease -negative symptoms- possible decrease -Side Effects: Decreased dystonia, EPS’s, Tardive Dyskinesia, Prolactinemia -best side effect profiles
37
antipsychotic side effects
-Parkinsonism-rigidity, tremor, bradykinesia, masklike facies. -TX- lowering dose, changing meds, adding anticholinergic (cogentin, artane) -Akathisia- restlessness, pacing, fidgeting, jitteriness. -TX- lowering dose, changing meds, propanolol, benzodiazepines, cogentin -Acute dystonia- muscle spasm, torticollis, tongue protrusion -TX- IM benadryl or cogentin -Tardive dyskinesia- involuntary movements after long term antipsychotic therapy. -begins with tongue or digits and progresses to face, limbs -TX- switching meds, lowering dose -usually a symptom for life
38
substance abuse
-3+; 12 months: -tolerance -withdrawal -substance taken in larger amounts of longer period intended -persistent desire, craving -failure to quit -time spent trying to get it, use it, recover -can get work, home, or school work done -social, occupational, recreational activities given up because of abuse -continue addiction even though they know the problem
39
alcohol withdrawal tx
-supportive -hydration- may have 6L deficit with DT -electrolytes -Thiamine -> decrease risk of Wernickes dementia -nursing care -tx of symptoms -> -benzos -antipsychotics -clonidine
40
opiate withdrawal sx and tx
-SX: -insomnia -cramps -dilated pupils -goose bumps -muscle twitching- restless legs -vomiting -diarrhea -going from 3 to 2 wont make a difference BUT -going from .5 to .25 -> pt will feel this -TX: -methadone, suboxone -clonidine -ultra rapid detox- naltrexone (opiate antagonist) administered under 6hrs general anesthesia -supportive
41
geriatric depression
-worse in morning -wt loss -guilt -memory failure -somatic sx -sx wrongly attributed to dementia, or other condition -> pseudodementia ->65yo is 20% of all suicides -increase risk in nursing homes -increases disability -36%- respond well -34%- response but relapse -30% poor response -most specific- irritability and anhedonia
42
pseudodementia
-45% of dementia pts have depression -mimic dementia but is actually depression -psychomotor retardation -Selective mutism and poor appetite -Poor attention and concentration -Symptoms resolve as depression is treated -If cognitive impairment remains -> underlying dementia is suspected -Highest risk- > 65
43
rating scales
-Geriatric Depression Scale (GDS): A self-rated scale that focuses on internal experience and is valid and reliable in mild dementia -Beck Depression Inventory (BDI): most widely used self rating scale with focus on emotional/somatic symptoms -Zung Self Rating Depression Scale (SDS): 20 question self rating scale; screening tool in general practice offices -Hamilton Depression Scale (HDRS): A interview that focuses on somatic and vegetative symptoms -Cornell Scale for Depression in Dementia: sensitive for superimposed depression -Median sensitivity (true positive rate) of the most common depression screening scales: 85%
44
geriatric depression dx and tx
-assess pain, insomnia, GI -assess thyroid, B12, meds -environmental changes -involuntary hospital admission- suicidal, homicidal, gravely disabled -antidepressents- more susceptible to SE -> low and slow -long half life -do not undertreat -tx for life is 3+ episodes -minimum 4-9 months beyond symptom resolution with first episode
45
psych emergencies
-intoxication, withdrawal, rapid changes in behavior -inpatient -> extended observation -> release with initial Rx -> f/u appt w/ psychiatrist/therapist/clinic -mini-MSE
46
standard psych emergency labs
-CBC with diff- infection -chemistry- electrolyte imbalance, hypoglycemia, hyperglycemia -TSH- hypo/hyper -B12 and folate -U-tox: substance abuse -UA- UTI -chest x ray- infection -EKG- acute MI, arrythmia, QTC -RPR- syphilis -Beta HCG- pregnancy -all systems are important for PE BUT -> -Pay attention to Vitals, HEENT, and Neurologic systems
47
90% of suicide
-Major Depressive Disorder -Bipolar Disorder, Depressive Phase -Alcohol or Substance Abuse- 10% -Schizophrenia -Personality Disorders like Borderline Personality Disorder -male- 75% of suicide completers -women- 3x more attempts than males
48
suicidality
-never leave pt -consider hospitalization if: -substance abuse -strong intent -access to weapons/harm -delirium -dementia -consider discharge if: -positive response to initial intervention -good social support -medically stable -impulse action while under influence -> stable after extended observation
49
protective factors
-reduce likelihood of suicide -enhance resilience -counterbalance risk factors -care for mental, physical, and substance use disorders -Easy access to clinical interventions and support -Restricted access to lethal means of suicide -Strong connections to family and community -Support through ongoing medical and mental health care relationships -Skills in problem solving -Cultural and religious beliefs that discourage suicide and support self-preservation
50
homocidality risk
-#1: history of violence -psychosis- schizophrenia, depressive, mania -substance abuse -personality disorder- paranoid, antisocial, boderline -neurological impairment- TBI, delirium, dementia -chaotic family event -physical/sexual abuse -poor coping skills -impulsive -close to weapons
51
tarasoff precedent
-1976 CA rulings -Mental Health Providers have duty to protect 3rd parties from dangers of their clients -Tarasoff Precedent- Psychiatrists should contact 3rd parties or police if threat is made to identifiable victim, the pt has capability to carry out act and is likely to do so soon -Psychiatrists determine if threat is valid -if someone says they are going to beat someone up -> dont report -if someone is specific with a plan -> report
52
mania/psychosis/aggression tx
-Haldol 2.5-5.0 mg IM q 2-4 hours PRN acutely -Given with Cogentin 2.0 mg IM, Benadryl 50.0 mg IM, or Ativan (counteract EPS) -Long term- Mood stabilizer (Lithium vs Depakote) -Geodon 10.0-20.0 mg IM May give q 2hrs PRN (Cogentin or Benadryl not needed) -Neuroleptics also FDA approved -Haldol used as a mood stabilizer in pregnancy -consider long term antipsychotics -consider mood stabilizer -admit if indicated
53
neuroleptic malignant syndrome
-rare, life threatening -rxn to neuroleptic med -fever, rigidity, AMS, and autonomic dysfunction -tachy, hypo/hypertension -labs- leukocytosis, increased CPK, myoglobinuria -TX: -D/C med immediately -supportive- IV, cooling blankets, ventilation -muscle relaxant- dantrolene: 2-3 mg/kg per day by IV in TID or QID doses. -Dopamine Agonist: Bromocriptine: 5 mg QD-QID, Amantadine: 100 mg BID
54
physical restraints
-only temporary solution -staff must 1st attempt structure (redirecting pt to more appropriate behavior) and meds before restraint can be legally applied -If pt strikes another person -> legally considered a danger -> restraint may be applied -Every restraint attempt- explain to pt and family purpose of restraint and obtain consent -remove restraints at least every 2 hrs to reassess and allow for ADLs -Restraints are “prescription devices” -> require physician’s orders -Documentation: pt’s behavior, type of restraint, circulation status, vital signs, medical reason for applying restraints, time restraints used, and any alternatives that were tried -Circulation checks: At least every 2 hrs, fluids and foods given, and care for personal hygiene -Renewal of order every 2 hrs. -Often remains on 1:1 during this duration
55
inpt admissions
-CPEP (comprehensive psychiatric emergency program) -voluntary/involuntary -CPEP: -Standard for Admissions: -immediate observation, care and tx is appropriate -illness must carry “likelihood of serious harm” -Duration of Stay: Up to 72 hrs involuntarily (with VALID DOCUMENTATION AND justification) -> after pt must be discharged or admitted involuntarily for further observation and tx -After 24 hours -> switched to extended observation beds -VOLUNTARY: -mental hospital is appropriate -needs a written request for admission and discharge from pt -duration- if hospital feel pt needs to stay involuntary -> must apply to judge within 72 hrs for authorization to keep pt