Final Flashcards
(66 cards)
Explain each of Darwin’s 4 postulates.
Genetic variation
Overproduction
Competition
Favorable trait that increases survival + reproduction
Discuss how together the 4 postulates result in a shift in the traits of a population between generations.
Overproduction leads to competition for limited resources, which creates selective pressures. When certain heritable traits provide a survival advantage, those traits become more common in the pop over time, especially if there is enough genetic variation for natural selection to act upon. This process results in a shift in traits as advantageous characteristics are passed on to future generations.
Based on the postulates explain how natural selection could fail to result in evolution. 3 points
Nat sel could fail to result in evol if…
(1) there is little to no genetic variation for nat sel to act upon. E.g small pops
(2) the trait is non-heritable
(3) there is a lack of competition as there is no challenges in survival meaning the presence or absence of certain traits may NOT impact survival/reproduction
Explain the different types of mutations.
6 total + causation
- Point muts → silent; missense (change in aa); nonsense (early stop codon)
- Indels → frameshift
- Inversions → suppressed recom
- Duplications → neo/subfunctionalization
- Aneu/polyploid → replication error
- Chromo fusion
Explain how gene duplications can facilitate rapid evolution of new function. Define the 2 terms
via Neo/sub functionalization
Neo - 1 copy evolves a new function; other retains og function
Sub - share og function w/ independent ne functions
Differentiate synonymous from non-synonymous mutations and germline from somatic mutations.
Synonymous → no aa change
vs.
Nonsynonymous/missense → aa change
Germline → muts in eggs/sperm; heritable
vs.
Somatic muts →muts in body cells; not heritable
Explain the difference between different modes of inheritance (ways by which cell division occurs)
2 modes
Sexual - segregation during meiosis; recombination during crossing over, creating new allele combos); increases genetic variation
Asexual - genetic clone; no recomb; no meiosis; no genetic variation
Explain how meiosis contributes to variation in allele frequencies.
indirectly via segregation - the separation of homologous chromosomes where each gamete gets a random combination of maternal + paternal alleles
Segregation introduces variation but doesn’t directly alter allele frequencies in a pop at large, assuming random mating + no other evolutionary forces
In smaller groups, random outcomes from segregation + fertilization can cause allele frequencies to shift
Understand what to use to calculate the expected genotype and allele frequencies under Hardy-Weinberg.
e.i. what #s go where? refer to orange notebook
Detect deviations in empirical data and interpret what it means for HW
expected vs observed
expected = observed, then evol is occurring
expected DOES NOT = observed, then evol is NOT occurring
what are the assumptions of Hardy–Weinberg equilibrium? 5 total
(1) random mating
(2) large population
(3) No muts
(4) No gene flow
(5) No nat sel
Explain dominance
when 1 allele wins over the other, affecting pheno
Explain epistasis
when 1 gene impacts another, affecting pheno
Explain pleiotropy
one gene impacts expression of multiple traits, changing pheno
Explain plasticity
a certain environment impacts gene expression, changing phenotype
Explain how fitness relates to natural selection. define fitness
natural selection favors organisms w/ higher fitness while acting to remove those w/ lower fitness
fitness - an organism’s ability to survive + reproduce in its environment
Explain how differences in fitness result in evolutionary change.
Organisms w/ higher fitness are more likely to survive + reproduce due to their adaptations to the environment
Over time, accumulation of beneficial traits in individuals w/ higher fitness leads to evolutionary change given said traits are to be passed down more frequently
Distinguish between absolute and relative fitness.
Absolute: expected # of offsprings produced
Relative: observed. # of offsprings produced
Describe the different fitness components. 4 total
Viability - organism’s ability to survive to reproductive age
Fecundity - how many offspring produced
Mating success + Fertility success
Define a selection coefficient and understand what it means
Measures strength of nat sel acting on allele; Used to compare relative
FITNESS of different genotypes
- SC = 0, NO selective dis/advantage
- SC > 1, selective advantage
- SC < 1, selective disadvantage
Calculate the change in allele frequency based on strength of selection + starting frequency
Explain how heterozygote advantage and frequency-dependent selection can maintain genetic variation. Define both terms
Heterozygote advantage → favors the heterozygous genotype
Freq-dependent sel → increases rare alleles
mechanisms ensure that diff alleles are maintained in the pop, preventing the loss of genetic diversity
Explain mutation-selection balance.
equilibrium between the rate at which new muts arise in a pop and the rate at which they are removed by natural selection
Define migration (from an evolutionary vs. ecological perspective) and explain its effect on allele frequency.
Migration evol = gene flow
—-> Introduces new alleles into a pop, potentially increasing genetic variation
Migration ecol = seasonal or regular movement of individuals or species from one area to another
—-> indirect effects on allele freq