Final

Question 1

Hypersensitivty mediated by IgE

Answer 1

Type 1

Question 2

Type 3 hypersensitivity is best described by

Answer 2

requires immune complex formation

Question 3

All are true about erythroblastosis fetalis except

Answer 3

most severe during 1st pregnancy

Question 4

X linked primary congenital humoral immunodeficiency

Answer 4

Bruton’s

Question 5

Death in a case of systemic anaphylaxis usually due to..

Answer 5

asphyxiation

Question 6

Natural Suppression can be explained by..

Answer 6

clonal deletion theory
clonal anergy theory
suppression

Question 7

T/F Tolerogens activate lymphocytes

Answer 7

T

Question 8

Blood transfusion rxn is what type?

Answer 8

II

Question 9

T/F Products of MHC mainly regulate transplantation, immune responsiveness, and aspects of complement synthesis

Answer 9

True

Question 10

Graft versus host disease occurs because of ___________ in the graft tissue.

Answer 10

T cells

Question 11

An Arthus reaction is characteristic of which type of hypersensitivity reaction?

Answer 11

III

Question 12

Increased susceptibility to fungal, viral and protozoan infections is associated with

Answer 12

T cell deficiencies

Question 13

In this mechanism of suppression the body makes antibodies against its own antibodies.

Answer 13

Production of anti idiotype antibodies

Question 14

This theory to explain natural tolerance holds that cells with high affinity for self antigens are destroyed in the primary lymphoid organs.

Answer 14

Clonal deletion

Question 15

Which of the following is a graft between genetically different members of the same species.

Answer 15

Allograft

Question 16

Graft versus host reaction frequently develops following transplantation of

Answer 16

bone marrow

Question 17

Tolerance to endogenous antigens is

Answer 17

natural tolerance

Question 18

Which type of hypersensitivity is due to the presence of IgE?

Answer 18

I

Question 19

Which type of hypersensitivity is due to T cell reactivity?

Answer 19

IV

Question 20

The most common immunodeficiency disorder is

Answer 20

Selective IgA deficiency

Question 21

ediak-Higashi Syndrome is characterized by

Answer 21

problem with phagocytosis

Question 22

In this congenital disease the lymphocytes lack MHC markers

Answer 22

bare lymphocyte syndrome

Question 23

Serum sickness from the administration of horse immunoglobulin results in
a systemic ____________ hypersensitivity reaction.

Answer 23

Type III

Question 24

Mechanism/s for cell damage in type II hypersensitivity

Answer 24

Classical complement cascade
natural killer cells
opsonization

Question 25

Incompatible blood transfusion could induce a hemolytic reaction that results in intravascular lysis of the RBC’s, and release of ------------from lysed cells.

Answer 25

Hemoglobin

Question 26

2. The lack of immune response for self-antigens in the tissue is caused by: a. Deletion of self reactive cells b. Inactivating the cell (anergy) c. Optimization d. A and B

Answer 26

D

Question 27

This tolerance is unresponsive to self-antigens ( all the endogenous antigens). a. Natural tolerance b. Active tolerance c. Acquired tolerance d. Autoimmune disease

Answer 27

A

Question 28

Function of T suppressors cells is important in suppression. a. True b. False

Answer 28

A

Question 29

In Graves’ disease, antibodies blood, the TSH ( thyroid stimulating hormone) receptors on the thyroid gland. a. True b. False

Answer 29

A

Question 30

Which of the following autoimmune disease is associated with butterfly rash on the face? a. Diabetes mellitus b. Graves’ disease c. Myasthenia gravis d. Systemic lupus ( SLE, Red Wolf)

Answer 30

D

Question 31

Which of the following factors is/are involved in insulin dependent diabetes mellitus autoimmune disease? a. Infection b. HLA gene c. A and B d. None of the above

Answer 31

C

Question 32

Which one of the following biochemical/s is/are going to be reduce in Hashimoto’s thyroiditis? a. Interferon b. Insulin c. Thyroxin d. All of the above

Answer 32

C

Question 33

Which of the following is called rheumatoid factor? a. IgE-antibody against F-ab portion of a patient’s own IgG b. IgM-antibody against F-ab portion of a patient’s own IgG c. IgM-antibody against F-c portion of a patient’s own IgG d. IgG-antibody against F-c portion of a patient’s own IgM

Answer 33

C

Question 34

Multiple sclerosis is associated with which of the following types of hypersensitivity reactions? a. I b. II c. III d. IV and III

Answer 34

D

Question 35

The antibodies in warm agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins? a. IgG b. IgM c. IgE d. IgA

Answer 35

A

Question 36

14. Allografts of lymphoid tissue are particularly immunogenic because of the high content of a. MHC class II expressing cells b. MHC class III expressing cells c. MHC class I expressing cells d. A and B

Answer 36

A

Question 37

15. An example of a type III immune complex disease is a. Rheumatoid Arthritis (RA) (SLE) and scleroderma b. Contact dermatitis c. Graft rejection (host versus graft reaction) d. Atopy

Answer 37

A

Question 38

16. The localized reactions to injected antigens in the same body site such as booster shoot are called____________ a. Rheumatoid Arthritis (RA) b. contact dermatitis c. graft rejection d. Arthus reaction

Answer 38

D

Question 39

17. A positive tuberculin skin test is an example of a. A delayed type allergy b. Acute contact dermatitis c. Autoimmunity d. Eczema

Answer 39

A

Question 40

18. Contact dermatitis is cause by a. Pollen grains b. Chemical absorbed by the skin c. Microbes d. Proteins found in the food

Answer 40

B

Question 41

19. A graft transplanted between individual who are members of different species a. allograft ( b/w geniticaly non-identical (allogenic) members of the same species) b. Xenograft c. Autograft (from one side to another site in the same individual. d. Isograft (syngraft) ( b/w genetically identical members of the same species, as identical (monozygotic) twins or member of an inbread mouse

Answer 41

B

Question 42

20. Factors that affecting the immune system and decrease the immune functions are as follow: a. Chronic disease b. Long term physical activity c. Emotional stress d. A and C

Answer 42

D

Question 43

21. Patient with severe immunodeficiency disease in both T – cells and B – cells compartment accept a allogenic bone marrow graft. a. True b. False

Answer 43

A

Question 44

22. Natural antibodies have the following characteristics: a. Low affinity b. Low specificity c. Harmless d. Have some rule for clearing infection e. All of the above

Answer 44

E

Question 45

23. In natural tolerance 95% of apoptosis (PCD) of T cells found in: a. bone marrow b. thymus c. lymph nodes d. spleen

Answer 45

B

Question 46

24. Central Tolerance is within _______ a. Bone marrow b. Thymus c. Lymph node d. Spleen

Answer 46

B

Question 47

Matching: Post-Streptococal (Glomerulonephritis)

Answer 47

Immune complex disease

Question 48

Matching: Arthrus Reaction

Answer 48

Type III hypersensitivity (local)

Question 49

Matching: Serum Sickness

Answer 49

Type III hypersensitivity (systemic)

Question 50

Matching: Contact Hypersensitivity

Answer 50

Type IV

Question 51

29. T suppressor cells prevent _____ to make antibodies, and also prevent ________ from maturing into T –cytotoxic cells a. T cells, B cells b. B cells, T cells c. Macrophage, T cells d. B cells, macrophages

Answer 51

B

Question 52

30. Preexisting infections can have positive or negative effects on immune response. a. True b. False

Answer 52

A

Question 53

31. This is an induce tolerance in which an animal will failed to respond to non-self antigens (all exogenous antigens) from outside the body that would normally be immunologic.

Answer 53

Acquired tolerance

Question 54

32. Which of the following factors are involved in autoimmune disease a. Infection b. Hormonal c. Genetic d. All of above

Answer 54

D

Question 55

33. These monkey antigens (Rh factor) are presented in ___ of humans and absent in the other____

Answer 55

85%, 15%

Question 56

34. Transfusion reaction may cause a. Destruction of the transfused cells by hemolysis opsonization b. Increased phagocytosis c. All of the above

Answer 56

C