Final Flashcards
(133 cards)
1
Q
Herpesvirus - morphology
A
enveloped, icosahedral capside (100-110 nm)
2
Q
Herpesvirus- describe infection
A
self limiting but sever in immunocompromise/novel host
3
Q
Herpesvirus - human 1,2,3 conditions
A
oral, genital, chickenpox
4
Q
BHV-1 - diseases
A
abortion, IBR (rhinotracheitis), IPV (pustular vulvovag), IPB (pustular balanoposthitis)
5
Q
EHV 1 and 4 - necropsy
A
Rhinopneumonitis (1/4)- edema and petechiation; abortion (1/4) -fetus not autolyzed; neruo (1)- brain/spinal cord hemorrhage
6
Q
Herpesvirus inclusions
A
Intranuclear
7
Q
EHV 3 - condition
A
Equine coital exanthema
8
Q
Equine coital exanthema - incidence and occurence
A
worldwide, subclinical, with persistence and recurrence
9
Q
Rhinopneumonitis- viral cause
A
EHV 1 and 4
10
Q
Equine coital exanthema -etiology
A
EHV 3
11
Q
Equine coital exanthema -CS
A
vesicles on skin of vulva or penis that progress to erosions and scabs, heal in 2 weeks; secondary bacterial skin infection common, may leave depigmentation
12
Q
Human betaherpes
A
5, 6, 7 (cytomegalovirus, roseolovirus, pityriasis rosea
13
Q
Human gamma herpes
A
4, 8 (eppstein barr, kaposi’s sarcoma)
14
Q
Sheep and wildebeast
A
Catarrhal fever!
15
Q
Poxvirus - morphology
A
Very large enveloped complex virion (brick vs ovoid)
16
Q
Poxvirus - lesions
A
Epitheliotropic - induces proliferative lesions
17
Q
Poxvirus - inclusions
A
Intracytoplasmic
18
Q
Poxvirus - pathogenesis
A
Self limiting to lethal, can be broad hosts, zoonotic potential
19
Q
Poxvirus - disease caused by
A
Chordopoxviruses (has 9 genera)
20
Q
Name the two zoonotic pox viruses
A
Chrodopoxviruses: Orthopoxvirus and parapoxvirus
21
Q
Orthopoxvirus- infection
A
Cowpox virus
22
Q
Orthopoxvirus- species
A
Man, cattle, cats, zoo species
23
Q
Parapoxvirus- infection
A
Pseudocowpox virus, bovine papular stomatitis, orf virus
24
Q
Parapoxvirus- species
A
sheep, cattle, goat, human
25
Pseudocowpox- describe
Pathognomonic ring/horseshoe lesion, teat lesions proliferative, milker's nodule in humans
26
What is the most important pox virus of all domestic animals
Sheeppox, goatpox, LSD (lumpy skin disease) of cattle
27
Sheeppox, goatpox, LSD - mortality/morbidity
Mortality high especially in young, morbidity = loss of milk/meat
28
Sheeppox goatpox- etiology
Different species tropisms in each geographic region
29
Sheeppox goatpox- CS
Malignant (more common)- lesions, depression, fever, discharge, sudden death before lesions; Benign- only skin lesions under tail
30
Sheeppox goatpox- describe lesions
On unwooled skin and on buccal, respiratory, digestive and urognital mucosae
31
LSD of cattle- geo origin
SE africa- spreading
32
Sheeppox goatpox LSD- virus type
carpripoxvirus
33
LSD of cattle- CS
Respiratory and skin lesions, lymphadenopathy and edema
34
LSD of cattle- morbidity/mortality
Morbidity 100%, mortality 1-2%
35
LSD of cattle- differentiate from
pseudo-lumpy skin disease (BoVH2)
36
Fowlpox- describe lesions
Comb, wattle, face
37
Parvovirus- morphology and nucleic acid type
small, naked, icosahedral (18-26), linear ssDNA (5kb)
38
Parvovirus- replication
Replicates in rapidly dividing cells' nucleus (GI tract, WBC, pregnancy,
39
Parvovirus- inclusions
Eosinophilic intranuclear
40
Parvovirus- repro consequences
SMEDI- stillbirth, mummification, embryonic death, infertility
41
Porcine parvovirus- diseases
stillbirth, abortion, fetal death, mummification, infertility
42
Feline manifestation of parvovirus
Feline panleukopenia virus - cerebellar hypoplasia, panleukpenia, enteritis
43
Canine parvovirus- conditions
neonatal disease, enteritis, myocarditis, panleukopenia
44
Other species parvovirus
Mink enteritis (and panleukopenia), goose parvovirus (hepatitis)
45
Porcine parvovirus- disease
ONLY in pregnant! SMEDI syndrome- still birth, mummification, embryonic death, infertility
46
Cause of SMED in porcine parvovirus
Intrauterine infection that affects embryo or fetus
47
Canine parvovirus 2- CS
Subclinical common, severe most common in puppies 6w-6m - enteritis,hemorrhagic diarrhea, septic shock from villi destruction, myocarditis if infected in utero or in first week
48
Circovirus- morphology
Smallest known vertebrate DNA virus - naked, icosahedral
49
Circovirus- nucleic acid type
Circular ssDNA
50
Circovirus- species
birds and swine
51
Circovirus- replication
In cell nucleus of rapidly dividing cells- produces large basophilic intracytoplasmic and occasionally intranuclear inclusion bodies
52
Psittacine beak and feather disease- birds
cockatoos, parrots, budgerigars
53
Psittacine beak and feather disease- virus
circovirus, but usually subclinical
54
Psittacine beak and feather disease- pathology
Infects feather, beak and claw follicles - causes necrosis and feather malformation as they grow
55
What exceptions exist in herpes virus to their strong host specificity
pseudorabies, malignant catarrhal fever, herpes virus B in primates
56
What are the clinical manifestations of IBR, what kind of virus is it
Herpes alpha; genital lesions, respiratory disease, abortion
57
What are the clinical manifestations of EHV1
Abortion, paralysis/neuro, respiratory
58
What are the clinical manifestations of EHV 4
Respiratory only
59
What are the clinical manifestations of EHV 3
Genital lesions
60
malignant catarrhal fever is endemic to/is fatal to
Sheep/cattle, wildebeest/cattle in africa
61
Malignant catarrhal fever- CS
Mucopurulent discharge with lots of inflammatory cells, infects just about every oven
62
When is malignant catarrhal fever shed
During birthing provcess because mother is immunocompromised
63
What kind of virus causes bumblefoot
Poxvirus
64
What pox virus is not the normal shape?
Parapoxvirus is helical/spheroid instead of brick shaped like other poxviruses
65
What are the two zoonotic poxviruses
Ortho and para
66
Which pox virus has broad host specificity
ortho
67
Which pox virus can become systemic
Capripox has epitheliotropic component but is lethal due to systemic spread
68
Capripox- morbidity/mortality
high/low
69
Horsehoe shaped lesion on teat
Pseudocow pox
70
Hallmark of parvovirus morphology
no envelope, long environmental persistence
71
Parvo - inclusions
Intranuclear but some can have intracytoplasmic
72
Which parvovirus can have intracytoplasmic inclusions
circo
73
What kind of cells does parvovirus infect
rapid dividing- GI, embryo, respiratory, bone marrow
74
Compare and contrast feline panleukopenia and canine parvovirus
Feline- in utero infection causes cerebellar hypoplasia; canine parvo causes cardiomyopathy
75
Chem/CBC findings of parvovirus
low albumin, very lob WBC
76
What kind of virus is psitticine beak and feather disease
circo
77
Treat parvovirus
Enrofloxacin or FQs
78
Where is cowpox found
Europe
79
What kind of virus is cowpox-
Orthopox
80
Where are orthopox found
Worldwide
81
What kind of virus is pseudocowpox
parapox
82
Where is parapox found
worldwide
83
Where are capripox viruses found
Africa and asia
84
What is the reservoir for cowpox
Rodents
85
Name the parapox diseases
pseudocowpox, bovine papular stomatitis, orf virus
86
What feline conditions cause conjunctivitis
chlamydophila, mycoplasma
87
CS of herpesvirus in cats
corneal ulcers! rhinitis, pharyngitis,
88
CS of calicivirus
oral ulcers alone or pneumonia
89
Name a beta herpes virus
inclusion body rhinitis/porcine cytomegalovirus
90
Describe biological vector
Virus is amplified in the tissue of the vector
91
What is a mechanical vector
virus is not amplified, but carried from animal to animal
92
Reservoir host
Develops viremia at levels capable of infecting vector
93
Dead end host
Develop low viremia levels, doesnt transmit virus
94
What is an arbovirus
Arthropod born virus
95
Epidemic cycle
transmission cycle of outbreaks in humans only and animal-human disease
96
enzootic cycle
transmission cycle in animals continuing without outbreak level
97
Epizootic cycle
outbreak transmission cycle in animals (animal epidemic)
98
What kind of virus is West Nile
Falviviridae, ssRNA, enveloped
99
What is targeted for a vaccine in West Nile
E-glycoprotein - a surface protein with neutralizing activity
100
What is the only viremic host of West Nile
avian - esp crows
101
West Nile- horse CS hallmark
Fasciculation and head, neck, trunk tremors.
102
What is the diagnostic standard of west nile
IgM capture ELISA
103
What are the alphaviruses
EEE, WEE, VEE
104
EEE - disease
severe and fatal encephalitis- head pressing, seizures, paralysis
105
WEE- disease
milder form of EEE- mentation change, paralysis, less mortality
106
Diagnose alphavirus
IgM capture ELISA
107
VEE- life cycle
Endemic cycle between rats and mosquitos mutating to epidemic cycle between horses and mosquitos- becoming more pathogenic- horses become reservoir
108
VEE- CS
Severe mentation changes, headpressing, seizures, paralysis
109
VEE diagnosis-
IgM ELISA
110
Which alphaviruses have vax
EEE, WEE
111
What strains of VEE are low pathogenicity
IE (ID)
112
What strains for VEE arise from IE (?)
IAB and IC
113
What is the vector for VEE
Endemic mosquito
114
Adenovirus- morphology
Non-enveloped, large genome, intranuclear inclusions
115
Adenovirus- diagnosis
PCR with sequencing
116
Adenovirus- tx
cidofovir
117
Infectious canine hepatitis- virus
K9 adenovirus 1
118
K9 adenovirus 1- transmission
Ingestion/inhalation of body secretion
119
K9 adenovirus 1- CS
depression, abdominal pain, pale MM, blue corneal opacity, liver failure
120
Canine infectious tracheobronchitis- virus
K9 adenovirus 2
121
Canine infectious tracheobronchitis- CA2 - transmission
direct contact with infected secretion or contaminated fomite
122
Canine infectious tracheobronchitis- CA2 - CS
dry hacking cough without fever
123
Canine infectious tracheobronchitis- CA2 - Tx
rest, cough suppressant if not productive, Abx for secondary infection
124
Equine adenovirus- types
1- respiratory
| 2- pathogenic
125
Papillomavirus- morphology
small DNA virus that changes often, unenveloped and diverse
126
Papillomavirus- CS
Cutaneous lesions, can be oncogenic
127
Papillomavirus- inclusions
NONE!
128
Large firm lesions anywhere on body of horse, 20% of equie tumors
Equine sarcoids- bovine papillomavirus 1 or 2
129
Genital squamous cell carcinoma- virus
ecPV2
130
Polyomaviridae- morphology
small, round, non-enveloped dsDNA
131
Polyomaviridae- avian
Fatal hepatitis, nephritis, enteritis
132
Polyomaviridae- raccoons
brain tumors
133
Polyomaviridae- equine
nephritis
