Final Flashcards
(207 cards)
What is the primary determinant of equine joint health?
Articular cartilage
What component of equine articular cartilage synthesizes, organizes, and regulates the composition of the extra-cellular membrane?
Chondrocytes
What type of collagen is present in equine articular cartilage?
Type 2
Which component of equine articular cartilage counteracts the tensile stresses at the joint surface?
Collagen
What type of stress does collagen counteract at the joint surface?
Tensile
Which component of the equine articular cartilage resists compressive forces?
Aggrecan (a proteoglyan)
What force does aggrecan resist?
Compressive
How does articular cartilage receive nutrition?
Motion!
Cartilage has no blood supply
Compression expels water and soluble waste
Relaxation brings in water and soluble waste
What molecule contributes to synovial fluid viscosity?
Hyaluronan
What is the function of the synovial fluid?
Lubricate gliding surface
Nutrition supply and waste removal from cartilage
What is the Matrix Metalloproteinase inhibitor?
Tissue Inhibitor of Metalloproteinases (TIMP)
What are aggrecanases?
A distintegrin and metalloproteinase thrombospondin motifs
ADAMTS
What are the inflammatory cytokines in articular cartilage and what do they do?
IL-1 and TNF-a
Increase production of MMPs, oxygen free radicals, and prostaglandins
Inhibit collagen and aggrecan synthesis
Upregulate each other
What is the function of prostaglandins in articular cartilage?
Proteoglycan degradation
Sensitizes nerves to mediators of pain
Production stimulated by IL-1
What types of repair does cartilage undergo?
- Intrinsic: chondrocyte synthetic activity
- Extrinsic: cells from marrow cavity, requires penetration of subchondral bone
- Matrix flow: cartilage melts into fill lesion
What are the major classes of equine joint disease?
- Developmental orthopedic disease
- Traumatic/degenerative arthritis
- Septic arthritis
- Immune-mediated polyarthritis
What are examples of equine developmental orthopedic diseases?
Osteochondrosis
Osteochondritis dessicans
Subchondral bone cysts
Delayed ossification
T/F: traumatic/degenerative osteoarthritis causes irreversible changes to the joint
True
What tissue changes are seen with equine osteoarthritis?
Synovitis
Capsulitis
Ligamentous or meniscal injury
Primary cartilage injury
What is the gold standard in diagnosing equine osteoarthritis?
Arthroscopy
What clinical signs are associated with equine osteoarthritis?
Pain
Synovial effusion
Decreased range of motion
Local inflammation
What would you expect to see on radiographs of a horse with osteoarthritis?
Enthesiophytes
Osteophytes
Joint space narrowing
Subchondral bone sclerosis and/or lysis
Osteochondral fragments
For horses with osteoarthritis, does the severity of radiographic changes correlate with the amount of pain?
NO
What are the main goals in treating equine osteoarthritis?
Remove inciting cause*
Slow the progression of degeneration
Alleviate clinical signs
Restore function
Improve quality of life