Final Flashcards
(55 cards)
Define osteoinduction.
New bone formation from differentiation of osteoprogenitor cells into osteoblasts
_________ is a cytokine that acts on progenitor cells to initiate osteoinduction.
BMP
T/F: BMP is higher in cortical bone than in cancellous bone.
True
T/F: Osteoconduction involves the production of bone.
False
Creates a scaffolding that conducts bone forming cells from the host
__________ is the formation of new bone from osteoprogenitor cells.
Osteogenesis
Which type of graft possesses osteogenic properties?
Autogenic grafts
During phase I of osteogenesis, transplanted cellular bone produces new __________.
Osteoid
What determines the quantity of bone that the graft will form?
Number of bone cells that survive phase I
Which phase of osteogenesis determines the quality of bone?
Phase II
Initial woven bone replaced by lamellar bone. BMP released by matrix as graft is resorbed
What is the gold standard of bone grafts?
Autograft
Most frequently used in OMFS, from same individual
__________ are osteoconductive and are harvested from human cadaver.
Allograft/homograft
___________ are transplanted between individuals fo different species.
Xenografts
T/F: Recombinate grafts are approved for children.
False
What are some common reasons for compromised would healing?
Medication, radiotherapy, infection, systemic disease
What are some diseases associated with bone healing problems?
- Medication related osteonecrosis of the Jaws (MRONJ)
- Osteo-radio-necrosis
- Osteomyelitis
What drugs are associated with MRONJ?
- Bisphosphonates
- Anti-resorptive agents
- Anti-angiogenic medications
T/F: Bisphosphonates inhibit osteoclasts and have a high affinity for calcium.
True
T/F: Patients with multiple myeloma take oral bisphosphonates.
False
IV
What are the parameters for diagnosis of MRONJ?
- Current or previous bisphosphonate treatment
- Exposed bone for more than eight weeks
- No hx of radiation to jaws
What are the three stages of osteo-radio-necrosis?
- Superficial (cortical bone)
- Localized (cortical and medullary bone)
- Diffuse (including inferior border)
_________ is an inflammatory process of bone marrow that involves cancellous and cortical bone with a tendency of progression.
Osteomyelitis
T/F: Osteomyelitis is more common in the mandible.
True
What is the antibiotic of choice for osteomyelitis?
Clindamycin
T/F: Dry socket can last for over 1 week.
False
If this long think osteomyelitis