Final-Antidepressants Flashcards
(167 cards)
1
Q
What is the goal of antidepressant therapy?
A
Alleviate signs and symptoms
2
Q
What are the 3 types of depression?
A
-Reactive
-Major Depressive Disorder
-Bipolar Affective
3
Q
What is the most common type of depression?
A
Reactive
(reaction to an event)
4
Q
What are the 3 categories of the symptoms of depression?
A
-Physiological
-Psychological
-Cognitive
5
Q
What are the physiological features of depression?
A
-Decreased sleep
-Appetite changes
-Fatigue
-Psychomotor dysfunction (clumsiness, etc)
6
Q
What are the psychological features of depression?
A
-Dysphoric mood
-Worthlessness
-Excessive guilt
-Loss of interest/pleasure in all or most activities
7
Q
What are the cognitive features of depression?
A
-Decreased concentration
-Suicidal ideation
8
Q
What needs to be ruled out in a diagnosis of depression?
A
That it is not caused by:
-Drugs
-Medical condition
-Bereavement
9
Q
Which antihypertensive/cardiovascular drugs can induce depression?
A
-Reserpine
-Methyldopa
-Propranolol + Metoprolol
-Prazosin
-Clonidine
-Digitalis
10
Q
Which sedative-hypnotic drugs can induce depression?
A
-Alcohol
-Benzodiazepines
-Barbiturates
-Meprobamate
11
Q
Which anti-inflammatory/analgesic drugs can induce depression?
A
-Indomethacin
-Phenylbutazone
-Opiates
-Pentazocine
12
Q
Which steroid drugs can induce depression?
A
-Corticosteroids
-Oral contraceptives
-Estrogen withdrawal
13
Q
What other drugs can induce depression?
A
-Anti-parkinson
-Anti-neoplastic
-Neuroleptics
14
Q
What is the Biogenic Amine hypothesis of depression?
A
Reserpine depletes NE and 5HT from vesicles which causes depression
-Therefore, agents that increase NE and 5HT are effective for treating depression
15
Q
How does Reserpine (BP drug) cause depression?
A
Depletes NE and 5HT from vesicles
16
Q
What is the Neuroendocrine Hypothesis of depression?
A
There are changes in the Hypothalamic-Pituitary-Adrenal Axis (HPA) that cause it to be overactive
-Stress causes hypothalamus to release CRF
-CRF promotes release of ACTH from pituitary
-This promotes release of cortisol from adrenal glands
*Overactive HPA and elevated CRF is found in almost all depressed patients
*Overactive HPA may desensitize feedback response in hypothalamus and pituitary
*Antidepressants and Electroconvulsive therapy (ECT) lower CRF levels
17
Q
What does elevated CRF cause?
A
-Insomnia
-Anxiety
-Decreased appetite
-Decreased libido
18
Q
How does the Neuroendocrine Hypothesis relate to depression treatment?
A
Antidepressants and Electroconvulsive therapy (ECT) reduce CRF levels
19
Q
What is the Neurotrophic Hypothesis of depression?
A
Brain-derived neurotrophic factor (BDNF) is critical in: neural plasticity, resilience, neurogenesis
*Stress and pain decrease BDNF
*Decreased BDNF causes depression
*Antidepressants increase BDNF levels
Brain Chemistry:
-dendritic sprouts disappear due to loss of BDNF
-this loss of sprouts leads to a depressed state
20
Q
How does the Neurotrophic Hypothesis relate to depression treatment?
A
Antidepressants increase BDNF levels
21
Q
How do the depression hypotheses integrate together?
A
HPA and steroid abnormalities regulate BDNF
Cortisol activates hippocampal glucocorticoid receptors, decreasing BDNF
Chronic monoamine receptor activation increases BDNF signaling and downregulates the HPA axis
22
Q
True or False: The effects of antidepressants take days to weeks to occur but the body’s biochemistry immediately changes
A
True
-antidepressants cause an immediate change in serotonin levels and body chemistry
23
Q
How long does antidepressant therapy take to work?
A
2-3 weeks
24
Q
Why does antidepressant therapy take so long to work?
A
NO ONE REALLY KNOWS
Neuroadaptive responses?
-Antidepressants increase the amount of neurotransmitter in the intrasynaptic space
–Could cause delay due to pre/postsynaptic adaptation or activation of receptors
25
What is the MOA of MAOIs?
-MAO normally degrades norepinephrine (NE) and serotonin (5HT)
-When MAO is inhibited, more NE and 5HT is packaged into vesicles
-This results in more NE and 5HT being released into the synapse
(increase NE and 5HT)
26
What are the non-selective MAO inhibitors?
Phenelzine (Nardil)
Tranylcypromine (Parnate)
27
What are the MAO-B selective inhibitors?
Selegiline (Eldepryl/Ensam)*
Safinamide (Xadago)
28
What is the MAO-A selective inhibitor?
Moclobemide (Manerix)
*only in Europe
29
When are non-selective MAO inhibitors reserved for?
Drug treatment resistant depression
30
Whis MAO inhibitors are reversible and which are irreversible?
Non-Selective: Irreversible
MAO-B Selective: Reversible
MAO-A Selective: Reversible, only Europe
31
Which MAOI is only used in Europe?
Moclobemide (Manerix)
-MAO-A Selective
32
What are the side effects of MAO inhibitors?
-Headache
-Drowsiness
-Dry mouth
-Weight gain
-Orthostatic hypotension
-Sexual dysfunction
*Hypertensive Crisis*
33
What drugs do MAOI interact with?
OTC:
-Cold preparations
-Diet pills
Rx:
-TCA's
-SSRI's
-L-DOPA
34
Foods with what amino acid should be avoided when taking MAOI's?
Tyramine
-Cheese, sour cream, sausage, bologna, salamis, red wine, avocado, banana, soy sauce, etc (any good foods)
35
What herbal product may be effective in depression due to its MAOI activity?
St. John's Wort
36
For antidepressants that function as reuptake blockers, what site do they bind?
Allosteric site
(*do not bind the active site, bind elsewhere*)
37
What is the MOA of Antidepressants that work as Reuptake Blockers?
-Antidepressants bind the allosteric site and are not transported
-They block transport of NE and serotonin into the synapse which increased their levels in the extracellular space
*Note: do not bind the orthosteric site (where serotonin binds)
38
What are the indications for Tricyclic Antidepressants (TCAs)?
-Depression
-Panic Disorder
-Chronic Pain
-Enuresis
39
What is an important point to remember about Tricyclic Antidepressant Overdose/Toxicity?
DANGEROUS
-Depressed patients are more likely to be suicidal
---More likely to commit self-harm or suicide 2 weeks into treatment
40
At what point in Tricyclic Antidepressant therapy are patients more likely to commit self-harm or suicide and why?
2 weeks into treatment
-when people are depressed they do not have enough energy to take their own life, but the medication can give them more energy before the antidepressant effects start so they commit suicide before they start actually feeling better
41
What are the tertiary amines TCA's?
Imipramine (Tofranil)
Amitriptyline (Elavil)
Clomipramine (Anafranil)
Doxepin (Adapin, Sinequan)
42
What is the function of the tertiary amine TCA's?
Inhibit BOTH NE and 5HT reuptake via NET and SERT
Also act as receptor antagonists:
-Antihistamine (H1)
-Antimuscarinic
-Antiadrenergic (a1)
43
What side effects are associated with the tertiary amine TCAs?
These cause THE MOST:
-Sedation
-Weight gain
-Autonomic SE
-Conduction disturbances of the heart
*many, not great
44
Which tertiary amine can also be used for Enuresis and ADHD?
Imipramine (Tofranil)
45
Which tertiary amines get metabolized to secondary amines?
Imipramine (Tofranil)
Amitriptyline (Elavil)
46
What is Impramine (Tofranil) metabolized to?
Desipramine
(*secondary amine)
47
What is Amitriptyline (Elavil) metabolized to?
Nortriptyline
(*secondary amine)
48
Which tertiary amine can also be used for OCD?
Clomipramine (Anafranil)
49
True or False: Secondary Amines cause more side effects than Tertiary Amines
FALSE
-secondary amines cause many less side effects
50
Secondary amines inhibit which transporters?
Better NET inhibitors than SERT
51
What are the secondary amine drugs?
Desipramine (Norpramin)
Nortiptyline (Pamelor)
Maprotiline (Ludiomil) -NET inhibitor
52
Which secondary amine TCA is a NET inhibitor only?
Maprotiline (Ludiomil)
*tetracyclic reduced side effects
53
What are the SE of ALL TCA's?
-Anticholinergic
-CV (elderly)
-Neurological
-Weight Gain
-Suicidal ideation
54
What is the MOA of SSRI's?
Block serotonin transporter pumps presynaptically
-Increase serotonin in the synapse
(14 serotonin receptors: 13 G-coupled, 1 inotropic)
55
What are the SSRI drugs?
-Fluoxetine (Prozac)
-Fluvoxamine (Luvox)
-Paroxetine (Paxil)
-Sertraline (Zoloft)
-Citalopram (Celexa)
-Escitalopram oxalate (Lexapro)
56
Which SSRI is associated with little autonomic SE and no sedation?
Fluoxetine (Prozac)
57
Which SSRI is an Isomer of citalopram?
Escitalopram oxalate
58
What are uses of SSRIs?
Depression
Alcoholism
OCD
Enuresis
PTSD
Eating Disorder
Social Phobias
Panic Anxiety
PMDD
GAD
59
What are the SE of SSRIs?
Not many, widely used
Nausea+ Vomiting/ Headache/ Sexual Dysfunction/ ANXIETY/Insomnia/ Tremor
SSRI Discontinuation Syndrome
Serotonin Syndrome
60
What are the signs of SSRI discontinuation syndrome?
"Brain Zaps"
Dizziness
Sweating
Nausea
Insomnia
Tremor
Confusion
Vertigo
61
Use of SSRIs with what drugs can cause serotonin syndrome?
MAOIs
TCAs
Metoclopramide
Tramadol
Triptans
St. John's Wort
62
What are the symptoms of serotonin syndrome?
Hyperthermia/ sweating
Muscle Rigidity
Restlessness
Myoclonus
Hyperreflexia
Shivering
Seizures
Coma
63
If Serotonin Syndrome occurs with use of SSRIs, how do we treat it?
Discontinue medication
Manage symptoms
Administer serotonin antagonists and benzodiazepines to control myoclonus
64
What are the two SSRI + 5HT partial agonists?
Vilazodone (Viibryd)
Vortioxetine (Brintellex)
65
What are the Tetracyclic and Unicyclic antidepressants?
-Maprotiline (Ludiomil)
-Mirtazapine (Remeron)
-Bupropion (Wellbutrin)
66
What is the only 5HT2 Antagonist/ SERT Inhibitor?
Trazodone (Dyserel)
67
What is an important side effect to remember for trazodone?
Sedating
-used for sleep!
Off-label-hypnotic (a1, H1, 5HT2)
68
What are the SNRI drugs?
Venlafaxine (Effexor)
Desvenlafaxine (Pristiq)
Duloxetine (Cymbalta)
Milnacipran (Ixel)
Levomilnacipran (Fetzima)
69
All of the SNRIs are inhibitors of what?
NET + SERT
70
What are the Norepinephrine Selective Reuptake Inhibitor Drugs (NSRIs)?
Reboxetine (Vestra, Edronax)
Atomoxetine (Straterra)
71
Which NSRI is not approved for use in the US?
Reboxetine
72
Which NSRI is used for ADHD?
Atomoxetine
*not found to be useful in depression
73
When examining a selectivity ratio for a drug, does a high or low number indicate MORE selectivity?
Low numbers indicate that the drug is more selective for that substance
Ex:
NE/ 5HT
1/3
=more selective for NE
74
What is an example of a Serotonin-Norepinephirne-Dopamine reuptake Inhibitor (SNDRI) or "Triple Blocker"?
Cocaine
75
What are the NMDA antagonists?
Ketamine
Esketamine (Spravato)
76
What are some considerations to make when using NMDA antagonists?
-Very expensive
-Only available through REMS restricted program
*Esketamine must be used in conjunction with an oral antidepressant
77
What treatment option are available for Postpartum Depression (PPD)?
SSRIs (fluoxetine, paroxetine)
SNRI (venlafaxine)
**Brexanolone (Zulresso)
CBT and counseling
78
What is the MOA of Brexanolone (Zulresso)?
Allopregnanolone levels increase during pregnancy
GABA-A receptors desensitize
Allopregnanolone levels return to normal postpartum
Brexanolone resensitizes GABA-A receptors
79
What are the non-pharmacological treatment options for depression?
-Electroconvulsive therapy
-Psychotherapy
-Hospitalization
80
Which drug originally developed as an antidepressant is now being used for hypoactive sexual desire disorder in females?
Filbanserin (Addyi)
"female viagra"
81
What is the % risk of a depressive episode reoccurring after 1 episode?
50-60%
82
What is the % risk of a depressive episode reoccurring after 2 episodes?
70%
83
What is the % risk of a depressive episode reoccurring after 3 episodes?
90%
84
Why is the % risk of recurrence of a depressive episode important to consider?
Determines the dose and duration of medication a person will receive
85
True or False: The risk of depression relapses becomes lower over time as duration of remission increases
True
86
What is a predictor of recurrence of depressive episodes?
Persistent mild symptoms during remission
87
True or False: Function deteriorates during a depressive episode and can never go back to baseline even upon remission
False, function will go back to baseline upon remission
88
To meet the DSM-5 diagnostic criteria for depression, patients must show at least 5 symptoms and at least ONE of them must be what?
Depressed Mood
or
Loss of Interest/Pleasure in Doing Things
89
Besides the main 2 symptoms of depression what are the others?
Sleep (insomnia/hypersomnia)
Interest (decreased)
Guilt (or worthlessness)
Energy (loss/fatigue)
Concentration (difficulties)
Appetite (changes; increase or decrease)
Psychomotor (agitation/retardation)
Suicidal (ideation)
SIGE CAPS
90
What are the 2 self-administered rating scales used for depression?
Patient Health Questionnaire (PHQ-9)
--determines efficacy of treatment
Mood Disorder Questionnaire (MDQ)
--rules out bipolar disorder
91
What are the 4 goals of depression treatment?
1. Reduce or eliminate signs and symptoms of depression
2. Restore occupational and psychosocial functioning to baseline
3. Reduce the risk of relapse and recurrence
4. Reduce the risk of harmful consequences (suicidal ideation)
92
How do we decide which depression pharmacotherapy to choose?
*Efficacy is generally comparable between classes*
-Patient preference
-Prior medication response
-Safety, Tolerability, Side Effects
-Co-occurring psychiatric and medical conditions
-Pharmacologic properties
-Cost
93
What are the 3 phases of depression treatment?
Acute
Continuation
Maintenance
94
How long does the acute phase of depression treatment last and what is its goal?
6-12 weeks or until remission of symptoms
Goal: Induce Remission
95
How long does the continuation phase of depression treatment last and what is its goal?
4-9 additional months (after acute phase)
Goal: Prevent Relapse
96
What patients should have the continuation of their depression treatment?
Recommended for all patients
97
How long does the maintenance phase of depression treatment last and what is its goal?
*Patient-specific duration
*Normally indefinite treatment if => 3 major depressive episodes
Goal: Prevent Recurrence
note: often 1 year, if recurrence 5 years, if 3rd recurrence then long term
98
What antidepressants have a boxed warning for suicidality?
ALL ANTIDEPRESSANT MEDICATIONS
99
What is the caveat to the boxed warning for suicidality associated with antidepressants?
Only refers to patients < or = 24 years of age
100
At what age do antidepressants actually show a decreased risk of suicidality?
> or = 65 years old
101
Which SSRI causes QTc prolongation?
Citalopram (Celexa)
102
What is citalopram a substrate of?
2C19
3A4
103
Which SSRI is the longest acting (longest half-life)?
Fluoxetine (Prozac)
Half-life (96-144 hours)
*Only SSRI not requiring a taper
104
Which SSRI does not require the dose to be tapered off?
Fluoxetine (Prozac)
-because of its long half-life
105
Which SSRI has an activating potential?
Fluoxetine (Prozac)
-has an active metabolite (norfluoxetine)
106
Fluoxetine inhibits two things, what are they?
2D6 inhibitor
3A4 inhibitor
*these are inhibited by its active metabolite (norfluoxetine)
107
What is the active metabolite of Fluoxetine (Prozac)?
Norfluoxetine
108
Which SSRI is only indicated for OCD treatment?
Fluvoxamine (Luvox)
109
Fluvoxamine is an inhibitor of two things, what are they?
1A2 inhibitor*
2C19 inhibitor
110
Which SSRI has anticholinergic effects making it one of the hardest to stop with an excessive taper?
Paroxetine (Paxil)
*not used much
111
Which SSRI is the only one with a teratogenic effect and what is the effect?
Paroxetine (Paxil)
-causes septal wall defect to the fetus
112
What are the two main side effects associated with Paroxetine?
Weight Gain
Sedation
113
What time of day should Paroxetine be taken?
Bedtime
-because of sedation side effect
114
Paroxetine is an inhibitor of two things, what are they?
2D6 inhibitor
2B6 inhibitor
115
Which SSRI causes more GI upset (nausea) than any others?
Sertraline (Zoloft)
116
Which SSRI is the best for nonadherent patients?
Fluoxetine (Prozac)
-because of long half-life and lack of taper
117
Which SSRI causes weight gain?
Paroxetine
118
Which SSRI causes weight loss?
Fluoxetine
119
What are the 3 side effects that every single SSRI can cause?
-Increased bleeding risk (platelet inhibition)
-Hyponatremia (elderly)
-Sexual dysfunction
120
What are the two most commonly used SNRIs?
Duloxetine
Venlafaxine
121
Which SNRI is the active metabolite of venlafaxine?
Desvenlafaxine
122
What is the biggest side effect associated with Desvenlafaxine?
Nausea
*major limiting factor of this drug
123
Which SNRI has no CYP interactions?
Desvenlafaxine
124
Which SNRI has an FDA warning for hepatotoxicity?
Duloxetine (Cymbalta)
125
What is Duloxetine an inhibitor of?
2D6
(good for pain too)
126
When must the dosing of Levomilnacipran (Fetzima) be adjusted?
Renal impairment or with strong 3A4 inhibitors
*note: this drug is a 3A4 substrate
127
What is an important dosing consideration with Venlafaxine?
Must be >150 mg/day to have norepinephrine effects
(Basically an SSRI before this)
128
At higher doses, venlafaxine has what activity?
2D6 inhibitor
129
What are the two most common side effects with SNRIs?
-BP elevation
-Nausea
130
What other conditions are SNRIs useful in?
-Pain syndrome
-Musculoskeletal Pain
-Fibromyalgia
-Neuropathic Pain
131
What is an important monitoring parameter with Duloxetine?
Need to obtain LFTs at baseline and when symptomatic or every 6 months
132
What is the most important tricyclic antidepressant to remember?
Amitriptyline (Elavil)
133
True or False: Tricyclic Antidepressants have a lot of side effects
True
134
What are the side effects associated with TCAs?
CNS: sedation, reduces seizure threshold, confusion
Anticholinergic: Blurred vision, urinary retention, constipation
Cardiovascular: orthostatic hypotension, tachycardia
Other: weight gain, sexual dysfunction
135
What is an important dosing consideration with TCAs?
*Narrow therapeutic index drugs*
Fatal in overdose as low as 1000mg (4-10 tablets) due to cardiac arrhythmias or seizures
136
What are the important pearls for MAO inhibitors?
Need 2 week washout period before switching antidepressants (5 weeks if switching from fluoxetine)
All require a tyramine diet except the selegiline 6mg/24 hr patch
Caution due to hypertensive crisis and serotonin syndrome
137
How long must we wait before switching from another antidepressant to an MAO inhibitor?
2 week washout period
(if switching from fluoxetine then a 5 week washout)
138
What are the two most concerning side effects with MAO inhibitors?
Hypertensive crisis
Serotonin syndrome
139
True or False: We cannot use combo therapy with MAO inhibitors
True
140
What is the only MAOi that does not require the Tyramine diet?
Selegiline 6mg patch
Note: 9mg and 12 mg DO require the diet
141
What is the MOA of bupropion (Wellbutrin)?
Dopamine and Norepinephrine reuptake inhibitor
142
What are the side effects associated with bupropion (Wellbutrin)?
*Stimulating: Insomnia + Appetite Suppression
143
What is an important dosing consideration with bupropion?
Only use the XL dosing!
-SR dosing has large fluctuations in peaks and troughs that increase the risk for seizures
144
When is bupropion (Wellbutrin) contraindicated?
Active seizure disorder
Eating disorders
145
What is bupropion an inhibitor of?
2D6
146
True of False: Bupropion is a combination product
True, can be used in combination with SSRIs and SNRIs
147
What is an important dosing consideration with Mirtazapine (Remeron)?
Sedation and increased appetite occur with doses < or = 15 mg/day
148
What warnings are associated with Mirtazapine (Remeron)?
Agranulocytosis
Increased cholesterol
149
True or False: Mirtazapine (Remeron) is a combination product
True -can be used with SSRI/SNRIs
150
What is an important dosing consideration with Trazodone (Desyrel)?
Higher doses are needed for depression
151
What are the side effects of trazodone?
-Orthostatic hypotension
-Priapism risk *emergency
152
What is the MOA of Vilazodone (Viibryd)?
Primarily SSRI, may have some 5HT1a agonism which can provide anxiolytic effects
153
True or False: Vilazodone (Viibryd) is a combination product
False!
-Do not use in combo with SSRI/SNRIs because it is an SSRI
154
What are the clinical pearls associated with Vilazodone (Viibryd)?
*Take with food*
-significant nausea
***bioavailability increases with food***
155
What is Vilazodone (Viibryd) a substrate of?
3A4
156
What is the MOA of Vortioxetine (Trintellix)?
SSRI + 5HT1A agonist + 5HT3 antagonist
157
True or False: Vortioxetine is a combination product
False!
-Do not use in combo with SSRIs or SNRIs because it is one
158
What side effect is caused less by Vortioxetine?
Less sexual dysfunction
159
What is Vortioxetine (Trintellix) a substrate of?
2D6
160
True or False: Serotonin Syndrome is a medical emergency
TRUE
161
How do we treat serotonin syndrome?
Stop offending agent
Can potentially use serotonin blocking agents (Cyproheptadine)
162
Which antidepressant is antidepressant withdrawal syndrome not common in?
Fluoxetine
163
True or False: Antidepressants with anticholinergic activity should be tapered no matter what
True
164
True or False: Antidepressant withdrawal syndrome is not life-threatening
TRUE
-not life-threatening but extremely uncomfortable
165
What are the FDA-approved augementation agents?
Aripiprazole
Brexpiprazole
Cariprazine
Quetiapine
166
What are the drugs that can be used for post-partum depression?
Brexanolone
Zuranolone
167
What is one of the most effective treatments for treatment-resistant depression?
Electroconvulsive Therapy (ECT)
