Final Biology Flashcards
(17 cards)
1
Q
WNT pathway key words
A
Increase eta catenin
Frizzled
LRP5/6
DVL
TCF activating target
2
Q
How are TSGs lost?
A
- Gene is lost
- Gene is mutated
- Epigentically silenced
- Expression reduced
3
Q
Oncogenes - think of lung/colorectal cancer mutations
A
- MET
- myc
- RAS
- EGFR
- BCR-ABL
- BRAF
4
Q
Non=homologous phases
A
G0/G1
5
Q
EGFR once activated binds to
A
GRB2 which then initiates MAPK
RAS/RAF/MEK/ERK
6
Q
TRegs in tumours
A
- Secrete IL-10 and TGF-B to inhbit T cells
- Inhbit APCs
- Inhbit CD8+
- Promote immune tolerence in the TME
7
Q
VEGF 1 and 2
A
1 Inhibits angiogenesis
2 Promotes angiogenesis
8
Q
What activates p53
A
ONCOGENE ACTIVATION
DNA damage, cell stress, aberrent growth signals
9
Q
Familial Polyposis Coli Pathway lost
A
APC -> KRAS -> p53
Regualtion of B catenin
10
Q
HHV
A
4 - EBV
8 - Kaposi’s
11
Q
Homologous repair
A
- MRN + ATM
- BRCA/P53/CHEK2
- RAD-51
12
Q
Conditions with impaired homologus repair
A
- BRCA
- Werner
- Bloom
13
Q
p53 role
A
Induces apoptosis if DNA Damage
14
Q
UVB damage:
A
- Pyramidine dimers
- G -> T
- Free radicals
15
Q
MEN1
A
3 Ps but not phaeo
16
Q
MEN2 gene mutation
A
RET
17
Q
A
