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Therapeutics > Final Drugs 10-19 > Flashcards

Final Drugs 10-19 Flashcards

1
Q

17a-hydroxylase

A

-more MC not enough steroids
-enlargemnt of adrenal glands
-HTN
-ambiguous genitalia
-progesteron

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2
Q

21-hydroxylase deficiency

A

-

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3
Q

Aminoglutethimide

A

-inhibit aromatase and P450scc
-block steroid production in some tumors

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4
Q

Ketoconaxole

A

-antifungal at low concentration
-inhibits P450scc, 17-a hydroxylase, 11-B hydroxylase
-tx HYPERglucocorticoid states (Cushing’s)

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5
Q

Testosteron

A

-feedback inhibition
-5a reductase to make DHEA
-aromatase to make estradiol
-dec HDL levels

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6
Q

5a-reductase inhibitors (antiandrogens)

A

-finasteride
-dutasteride
-tx BPH, baldness

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7
Q

Steroid ANTAgonists

A

-Cyproterone acetate
-Spirinolactone

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8
Q

Non-steroidal inhibitors

A

-Flutamide
-Enzalutamide
-tx prostate cancer

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9
Q

Estrogen mods

A

-17B OH required
-17-a blocks metabolism
-160OH dec
-hydroxyl

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10
Q

Nonsteroidal estrogens

A

-diethylstilbestrol
-chlorotrianisene
-tx menopause and prostate cancer

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11
Q

Tamoxifen

A

-prodrug
-SERM (partial)
-tx breast cancer
-inc thrombo
-prevent osteoporosis

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12
Q

Toremifene and Ospemifene

A

-SERMs
-tx breast cancer
-tx dyspareunia

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13
Q

Raloxifene

A

-SERM
-prevent osteoporosis
-dec LDL
-inc risk of clots
-dec risk of breast cancer

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14
Q

Clomiphene

A

-SERM
-stimulate oculation

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15
Q

Fulvestrant

A

-SERD
-tx for breast cancer in pt resistant to tamoxifen

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16
Q

SERMS

A

-tamoxifen
-toremifene
-ospemifene
-raloxifene
-bazedoxifene
-clomiphene

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17
Q

Aromatase inhibitors

A

-Anastrazole
-Letrozole
-Exemestane

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18
Q

Gonadotropin preparations

A

-Menotropins
-Urofollitropin
-Follitropin
-Lutropin
-hCG
-Chorio

19
Q

Inducing ovulation w gonadotropins

A

-use FSH during follicular phase
-add GnRH antagonist to prevent LH surge

20
Q

Gonadotropins for male infertility

A

-LH and FSH
-inject hCG 8-12 weeks

21
Q

GnRH analogs

A

-Gonadorelin, -elins
-IV every 1-4 hours
-pulsatile
-nonpulsatile inhibits FSH and LH = HYPOgonadism

22
Q

GnRH ANATgonists

A

-Ganirelix
-Cetrorelix
-Abarelix
-Degarelix

23
Q

Glucocorticoids

A

-stress hormones
-anti-inflammatory
-epinephrine
-cortisol
-NFkB = immunosuppression

24
Q

Epinephrine

A

-B agonist
-break glycogen to release glucose
-GC

25
Q

Cortisol

A

-gene, and protein effects
-long term response
-inhibit pro-inflammatory response

26
Q

Glucocorticoid effects

A

-inc blood glucose
-immunosuppresion
-anti-inflammation

27
Q

HYPOadrenalism

A

-destruction of cortex or dec ACTH secretion
-weak, anorexia, N/V
-low BP
-hyperpigmentation
-depression

-Addison’s Disease

28
Q

HYPERadrenalism (Cushing’s)

A

-tumors in adrenal cortex
-inc ACTH
-bruising/bad healing
-osteoporosis
-c. diff

29
Q

Corticosteroid pharma effect

A

-tx allergic rx, inflammation/immune disease
-asthma
-cancer

30
Q

Cortisone vs cortisol

A

-11 hydroxyl

31
Q

Synthetic Glucocorticoids

A

-Fludrocortisone
-Prednisone/prednisolone
-Methylprednisolone
-traimcinolone
-Dexamethasone
-Betamethasone

32
Q

Topical GCs

A

-triamcinolone acetonide
-fluconide
-bethamethasone
-21-cholorcorticoids

33
Q

Inhaled Gcs

A

-triamcinolone
-beclomethasone
-flunisolide
-budesonide
-mometasone
-fluticasone

34
Q

Side effects of GCs

A

-Na/H2O retention
-HTN
-wasting muscles
-bone probs
-moon face, buffalo hump (cushings)
-dec insulin response
-suppress immune system
-inc ulcer risk
-euphoria, depression
-cataracts
-Addison’s disease upon withdrawal (low ACTH response) (weakness)

35
Q

PG drugs

A

-Alprostodil
-Misoprostol
-latanoprost
-prostacyclin

36
Q

Alprostodil

A

-PGE1 ED

37
Q

Misoprostol

A

-PGE1
-abortion and PUD

38
Q

Latanoprost

A

-PGE2
-CONSTRICTION
-tx glaucoma

39
Q

Prostacycline

A

-PGE2
-DILATES
-tx pulmonary HTN

40
Q

Osteoarthritis tx

A
  1. acetaminophen, topical NSAID, IM corticosteroid
  2. opioid, surgery, duloxetine
41
Q

Osteoarthritis topical

A

-methol/camphor
-capsaicin cream
-diclofenac

42
Q

MHT

A
  1. patch
  2. bazedoxifene (SERM) + estrogen
43
Q
A

Therapeutics (78 decks)

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