Final Exam Flashcards
(10 cards)
What is the goal of PGx in practice?
to offer the right drug at the right time with the right dose to the right person
How many drug have pharmacogenomic information in the labeling?
> 300
What information is found on drug labeling?
- drug exposure and clinical response variability
- risk for adverse events
- genotype-specific dosing
- mechanisms of drug action
- polymorphic drug target and disposition genes
Event Characteristics of Adverse Effects
- serious, potentially fatal and irreversible
- difficult to predict
- alternative therapy available
Drug Characteristics of Adverse Effects
- narrow therapeutic index
What do drug and event characteristics not take into consideration?
gene characteristics such as SNP or haplotype predictive power, specificity, etc
The decreasing costs of what has increased the amount of genetic information available to clinicians
high throughput genetic screening
SNPs that change clinical outcome
identifying a known SNP with a large clinical effect and adjust drug therapy or dosage (this is mostly where we are in clinical practice)
Human Genome Screening
GWS (including variants of unknown significance) with bioinformatic prediction to adjust drug therapy or dosage (this is where we are going in practice)
