Final Exam Flashcards
What is toxic granulation and why does it occur?
dark course granules in granulocytes (neutrophils) seen in peripheral blood smears in patients with inflammatory conditions. Common in patients with sepsis. thought to be due to impaired cytoplasmic maturation in the effort to rapidly generate large numbers of granulocytes.
In leukocytosis, what does neutrophil predominance suggest?
bacterial infections, actue inflammation, necrosis, MI
In leukocytosis, what does lymphocyte predominance suggest?
acute viral pinfx (EBV, CMV, viral hepatitis), chronic inflammation (TB, etc.)
In leukocytosis, what does eosinophilia suggest?
allergy (drugs, foods, inhalants) and parasitic infx
What is bandemia and what does it suggest?
excess of band cells (immature WBCs). signifies infection, sepsis, inflammation
What is mesenteric adenitis and what disease is it often confused with?
inflammation of mesenteric lymph nodes in the abdomen. Can be caused by Yersinia enterocolitica. May be confused with acute appendicitis if it occurs in the RLQ (preceeded by a sore throat)
How do you tell the difference between mesenteric adenitis and acute appendicitis?
mesenteric adenitis will have concomitant pharyngitis, HA and NO vomiting/rebound tenderness
What are the three areas of the lymph node and what type of cells do they contain in majority?
Paracortical areas: T-Cells
Secondary lymphoid follicle: B-Cells
Medullary cords: Macrophages and plasma cells
In an examination of an enlarged LN, you find that swelling is due to follicular hyperplasia. What disease is this associated with? Which immune cells are being activated here?
humoral immune response (RA, toxoplasmosis, early HIV infx….). Activated B cells
In an examination of an enlarged LN, you find that swelling is due to paracortical lymphoid hyperplasia. What disease is this associated with? Which immune cells are being activated here?
cellular immune response (drugs, acute viral infx, EBV, post vax). Activated T cells
In an examination of an enlarged LN, you find that swelling is due to sinus histiocytosis. What disease is this associated with? Which immune cells are being activated here?
distention and prominence of lyphatic sinusoid, nodes draining cancers such as carcinoma of the breast. endothelial and histioctyes are involved.
In regards to WBC neoplasms, what are two types of genetic derangements causing them?
lymphoid neoplasms: Hodgkins, non-Hodgkins
myeloid neoplasms: abnormal hematopoietic cell, myelodysplastic syndromes histiocytoses, multiple myeloma…AML, CML
How does the presentation of Hodgkins lymphoma differ from NHL in terms of tenderness and location?
HL present as non-tender nodal enlargement
2/3rd of NHL present as non-tender nodal enlargement
1/3 of NHL arise at extranodal sites
Majority of lymphoid neoplasms are from which types of cells?
80-85% are B-cell origin
How does Hodgkins Lymphoma spread?
lymph node to lymph node/ orderly
Which lymphoma has Reed-Sternberg cells?
Hodgkin Lymphoma
Compare/Contrast NHL and HL cellular findings:
NHL have mutations in B or T cells
HL is marked by the presence of Reed-Sternberg cells
Compare/Contrast NHL and HL age-ranges:
HL generally occurs in younger 15-24 aged patient and patients over 60
NHL is rare in young patients, most dxs made in patients >60
Compare/Contrast NHL and HL Incidence:
HL accounts for less that 1% of cancers in the US, about 15% of lymphomas.
NHL accounts for 4% of all cancers in the US, about 85% of lmphomas.
in both cases, men are affected more than women
Compare/Contrast NHL and HL Locations:
HL usually starts in the lymph nodes in the neck. however, it can spread to other lymph node groups. NHL can start in a variety of locations depending on the type of cancer and cells affected
Compare/Contrast NHL and HL Progression:
HL progresses in an orderly fashion between lymph nodes and is often caught before Stage IV.
NHL are less orderly, sometimes more aggressive and are more likely to be caught in advanced stages
What are the characteristics of ALL?
Hyperploidy is most common (>50 chromosomes). Philadelphia chromosome present- t(9;22)
What is the most common leukemia of adults in the western world?
CLL
What is the only leukemia not associated with radiation or drug exposure?
CLL
In which disease are smudge cells seen?
CLL
What are the characteristics of CLL and how does it present?
Morphology: BM involvement in all cases. tumor cells usually infiltrate the splenic and hepatic portal tracts. Chromosomal translocations are rare. They have a distinctive immunophenotype
Clinical Presentation: M:F 2:1; >50 yo; medial survival 4-6 years; lymphadenopathy, hepatosplemomegaly
GI infiltrates –> diarrhea, malabsorption, ulceration, megaloblastic anemia
disrupts normal immune function, hypogammaglobulinemia, Abs to RBC (AIHA and thrombocytopenia)
fatigue, wt los, anorexia, DOE, abd fullness, asymptomatic LA
What is the most common form of NHL?
follicular lymphoma
What infxs are associated with NHL?
EBV, HTLV-1, HepC, Kaposi Sarcoma, H.pylori
What does the genetic translocation leading to follicular lymphoma cause (in terms of product that is produced)?
over expression of bcl-2 protein (antagonist of apoptosis) promotes survival of follicular lymphoma cells
What are the 3 categories of Burkitts Lymphoma?
African (endemic) Burkitt lymphoma, sporadic (nonendemic), subset of aggressive lymphomas in HIV (highly undifferentiated Bcell lymphoma)
What is the morphology of Burkitss lymphoma?
intermediate sized lymphoid cells, “starry sky” pattern in LN, macrophage proliferation with ingested nuclear debris
What are genetic factors of Burkitts lymphoma?
c-MYC gene translocations on chromosome 8, latent EBV infection
What is the clinical presentation of Burkitts Lymphoma?
children/YA, manifestation at extranodal sites
endemic BL: mass in the mandible and abd viscera
sporadic BL: ileocecum/peritoneum abd mass
BM/Blood involvement is rare
an aggressive cancer that responds well to high-dose, short-term chemotherapy
Compare/Contrast multiple myeloma with Waldenstrom macroglobulinemia
MM (plasma cell myeloma): most important and most common monoclonal gammopathy
Waldenstrom macroglobulinemia: blood hyperviscosity due to high IgM, common in adults with lymphoplasmacytic lymphoma
Which infections are common in patients with multiple myeloma?
recurrent infxs with (s.pneum/s.aureus/e. coli). Most common cz of death d/t decreased production of Igs
What test is necessary to definitively dx MM?
Bone Marrow Biopsy
What 4 complications frequently occur in Waldenstroms macroglobulinemia?
Visual impairment (d/t retinal vein distention, retinal hemorrhages and exudate)
Neurological problems (HA/dizziness, deafness, stupod d/t sluggish blood flow)
Bleeding (complexes form)
Cryoglobulinemia (ppt of macroglobulins at low temp, sxsof Raynauds phenomenon and cold urticaria
In which disease are flower cells seen? What is the prognosis of this disease?
Adult T-cell leukemia/lymphoma. Dx is rapidly progressing and fatal in months-1 year