FINAL EXAM Flashcards
What are (8) common examples of trauma incidences in pediatrics?
Near drowning
Lawn mower accidents
Riding Accidents
Motor Vehicle Accidents
All-terrain vehicle accidents
Amish-Buggy Accidents
Burns
Dog bites
What are the major toxic effects of LA?
CV and CNS
LA crosses the BBB readily
Because of the lower/higher threshold for cardiac toxicity with bupivicaine, cardiac and CNS toxicity may occur virtually simultaneously in infants and children
Lower
What can happen if under GETA and having LA toxicity?
GETA with volatile anesthetics may obscure the signs of CNS toxicity until devastating CV effects are apparent.
CNS and CV signs of toxicity include what? 8 things?
- Circumpolar paresthesia
- Lightheadedness
- Tinnitus
- Slurred speech
- Muscle twitching
- Seizures
- Respiratory depression/arrest
- Ventricular arrhythmias/ cardiac arrest
What 3 channels does bupivacaine have a particular affinity for?
What effect does this have on resuscitative efforts?
Na
K
Ca
Makes resuscitation effort difficult after toxic dose of bupivicaine
Bupivicaine is highly bound to plasma proteins (a1- acid glycoprotein) and concentration of albumin and a1 acid glycoproteins are less/more in neonates which increases/decreases free (unbound) fraction of the LA that produces toxicity.
Less
Increased
After the accidental injection of large intravascular dose of bupivacaine, the progression from prodromal signs to CV collapse is slow and progressive. T/F?
False, it’s rapid
What is the resuscitation for toxic reactions of LA?
ABC
Patent airway, supplemental oxygen, reestablishing circulation and normal cardiac rhythm.
What can you give to terminate or prevent seizure activity?
Versed 0.05-0.2 mg/kg
Thiopental 2-3mg/kg
If they go into cardiac arrest from LA toxicity what should you give?
CARDIAC ARREST -> THINK INTRALIPIDS
Treatment of toxic reactions: Lipid sink hypothesis.
What is the mechanism of action of this mechanism?
1.5ml/kg of 20% IV lipid emulsion have shown to be effective for resuscitation of cardiac arrest due to bupivacaine toxicity.
The mechanism is not entirely understood, suspect that it binds free fractions of bupivicaine
What are the doses that can be repeated for LAST?
Yes dose can be repeated (max 3mL/kg) followe by a maintenence infusion rate of 0.25 mL/kg/min until circulation is restored.
Can propofol be used as a substitute for intralipid for resuscitation from bupivacaine Toxicity?
No
What should supportive treatment include for toxic reactions to LA?
IV fluid loading 10-0 mL/kg of isotonic crystalloid
Peripheral vasopressors (phenylephrine, norepinephrine)
Anti arrhythmic drugs
Phenytoin
ECMO
Where is the conus medullary in neonates/infants?
In neonates/infants up to 1 year it is located at L3 vs adults L1
Where is lumbar puncture for SAB in neonates/infants performed?
L4-L5 and L5-S1 to avoid going into spinal cord
Where does the tip of the SC end in the neonate?
L3
When does the tip of the SC achieve the normal adult position (L1-L2)?
1 year of age
Neonatal sacrum is narrower/wider and flatter/more pointy than in adults.
What does this do to your approach to the subarachnoid space?
Narrower and flatter
The approach to the subarachnoid space from the caudal canal is much more likely, so the needle must not be advanced deeply in neonates.
When is a caudal block contraindicated?
The presence of a deep sacral dimple may be associated with spina bifida occulta and greatly increasing the probability of dural puncture.
CSF volume as a percentage of body weight is less in infants and young children than in adults. T/F?
False, greater
Why do children require larger doses of LA for surgical anesthesia comparatively with a subarachnoid block in infants and young children?
The fact that CSF as a percentage of body weight is greater in young children than in adults.
The CSF turnover rate is considerably greater in infants and children, accounting in part for the much briefer duration of SAB agent compared with adults. T/F?
True