Final Exam - Misc. Flashcards
What factors define pathologic hyperbilirubinemia?
- Serum bilirubin above 95th percentile
- Jaundice that develops in the first 24 hr
- Rise in serum bilirubin >2 mg/dL/hr,
- Jaundice that persists >2 weeks in term infant
What is the overarching cause of pathologic hyperbilirubinemia?
Most common causes: disease processes that ↑ hemolysis and ↑ bilirubin production.
What are the specific processes that can cause pathologic hyperbilirubinemia?
- ABO incompatibility
- Known hemolytic disease of the newborn
- ↑ RBC breakdown from cephalohematoma or polycythemia (post-maturity, maternal diabetes, twin-to-twin transfusion, low fetal O2 levels)
- Sepsis
- Extensive bruising
- Poor breastfeeding
What conditions can lead to polycythemia in a newborn that lend to hyperbilirubinemia?
Post-maturity
Maternal diabetes
Twin-to-twin transfusion
Low fetal O2 levels
What is polycythemia?
An increase in the absolute red blood cell mass in the body.
What condition in the newborn is possibly caused by the following conditions?
Post-maturity
Maternal diabetes
Twin-to-twin transfusion
Low fetal O2 levels
Polycythemia
What condition in the newborn is caused by polycythemia?
Hyperbilirubinemia
What lever of serum bilirubin can cause cell death and necrosis?
Serum bilirubin levels >25 mg/dL can cause cell death and necrosis.
What is BIND?
Bilirubin-induced neurologic dysfunction (BIND) whereby bilirubin crosses blood-brain barrier & binds to brain tissue.
What happens in BIND?
Bilirubin crosses blood-brain barrier & binds to brain tissue.
What is the clinical manifestations of BIND?
Acute bilirubin encephalopathy (ABE) = the clinical manifestations of BIND. ABE may be permanent or reversible.
What is ABE?
Acute bilirubin encephalopathy.
Is ABE permanent or reversible?
Can be either.
What is kernicterus?
Kernicterus = permanent, irreversible effects of BIND (usually ABE s/s first)
Risk for kernicterus increases as serum bilirubin levels increase (>25 = 6%, >30 = 14-25% risk)
Nearly all infants with bili >35 have kernicterus
What is the level of bilirubin that is the risk for kernicterus?
Nearly all infants with bili >35 have kernicterus
The risk for kernicterus increases with what?
Risk for kernicterus increases as serum bilirubin levels increase (>25 = 6%, >30 = 14-25% risk)
What is the progression in a neonate for bilirubin levels >25 mg/dL?
- BIND - Bilirubin-induced neurologic dysfunction (bilirubin binding to brain tissue)
- ABE - Acute Bilirubin Encephalopathy (clinical manifestations of BIND)
- Possibly Kernicterus
(irreversible effects of BIND)
Symptoms of BIND
Lethargy
Fever
Irritability
Jitteriness
Hypotonia
Poor feeding
Apnea
Seizures
High-pitched cry
Symptoms of Kernicterus
Cerebral palsy
Sensorineural hearing loss
Gaze abnormalities
Dental enamel dysplasia
What condition in the neonate are the following symptoms of?
Cerebral palsy
Sensorineural hearing loss
Gaze abnormalities
Dental enamel dysplasia
Kernicterus
What condition are the following symptoms of in the neonate?
Lethargy
Fever
Irritability
Jitteriness
Hypotonia
Poor feeding
Apnea
Seizures
High-pitched cry
BIND
What is the treatment for infants with BIND and ABE?
Infants w/ BIND and ABE are treated with an exchange transfusion regardless of bilirubin levels.
T/F: Infants with BIND and ABE are treated with an exchange transfusion based on a bilirubin level > 35 mg/dL.
False. Infants w/ BIND and ABE are treated with an exchange transfusion regardless of bilirubin levels but definitely w/ serum bili ≥25 mg/dL with neurologic symptoms.
Nursing assessments for hyperbilirubinemia
- Visual inspection for jaundice
- Check ABO compatibility (maternal & newborn)
- Monitor serum bilirubin levels
- Maintain thermoregulation
- Assess for s/s of ABE