Final Review Blocks 1-3 Flashcards
(344 cards)
Norepinephrine
Mixed Agonist (Adrenergic)
- A1, A2, and B1
Epinephrine
Mixed Agonist (Adrenergic)
- A1, A2, B1, B2
- low doses = B1 and B2, high doses = A1
- treat acute anaphylaxis or cardiac arrest
Cocaine
NET, DAT, SERT Inhibitor (Adrenergic)
- vasoconstriction, MI, stroke, death
Methylphenidate
NET, DAT Inhibitor (Adrenergic)
- ADHD and narcolepsy tx
- anorexia, jitters, poor growth, priapism
Atomoxetine
NET Inhibitor (Adrenergic)
- ADHD tx
- low abuse potential because non-stimulant
Ephedrine / Pseudoephedrine
Indirect Sympathomimetic (Adrenergic)
- increase BP and HR
- don’t use with MAOi
Amphetamine / Methamphetamine
Indirect Sympathomimetic (Adrenergic)
- 1st line for ADHD in low doses
- jitters, poor growth, anorexia, addictive
Phenylephrine
A1 Agonist (Adrenergic)
- vasoconstriction
- used for decongestant, hemorrhoids, mydriasis
Clonidine
A2 Agonist (Adrenergic)
- treat HTN, ADHD, neuropathic pain
- causes hypotension, sedation, dry mouth
Phenoxybenzamine
Nonselective Alpha Antagonist (Adrenergic)
- non-competitive and irreversible
- A1 and A2 antagonist
- pheochromocytoma tx
Phentolamine
Nonselective Alpha Antagonist (Adrenergic)
- competitive and reversible
- A1 and A2 antagonist
- pheochromocytoma tx
Prazosin
A1 Antagonist (Adrenergic)
- decreases peripheral vascular resistance
- treats HTN, BPH, Raynaud’s
- “first dose phenomenon” = hypotension and syncope with first dose
Tamsulosin
A1 Antagonist (Adrenergic)
- decreases peripheral vascular resistance, more selective for prostatic urethra
- treats BPH primarily
- “first dose phenomenon” = hypotension and syncope with first dose
Dobutamine
B1 Agonist (Adrenergic)
- cardiac stimulation and renin release
- used for cardiac failure
- dysrhythmias
Albuterol
B2 Agonist (Adrenergic)
- Short acting
- Asthma and COPD tx
Terbutaline
B2 Agonist (Adrenergic)
- Short acting
- Asthma and COPD tx
Salmeterol
B2 Agonist (Adrenergic)
- long acting
- persistent asthma and COPD
Mirabegron
B3 Agonist (Adrenergic)
- OAB tx
- slow onset, can cause HTN
Esmolol
B1 Selective Antagonist (Adrenergic)
- tx for HTN, angina, arrhythmia, ischemia
- also used for intraoperative HTN
- rebound HTN = taper dose
- bronchoconstriction, bradycardia, CNS effects
- short half life
Metoprolol
B1 Selective Antagonist (Adrenergic)
- tx for HTN, angina, arrhythmia, ischemia
- also used for intraoperative HTN
- rebound HTN = taper dose
- bronchoconstriction, bradycardia, CNS effects
Propanolol
B1/B2 Nonselective Antagonist (Adrenergic)
- tx for HTN, angina, arrhythmia, ischemia
- migraine prophylaxis
- caution with asthma due to B2 effects
- rebound HTN = taper dose
- bronchoconstriction, bradycardia, CNS effects
Timolol
B1/B2 Nonselective Antagonist (Adrenergic)
- decreases aqueous humor production and reduces intraocular pressure
- bronchoconstriction, bradycardia, CNS effects
Labetalol
A/B Nonselective Antagonist (Adrenergic)
- Mostly B1 and B2 antagonism with some A1
- HTN tx and for Hypertensive Emergency
- rebound HTN = taper dose
- bronchoconstriction, bradycardia, CNS effects
Carvedilol
A/B Nonselective Antagonist (Adrenergic)
- 10:1 B1 and B2 to A1 antagonism
- HTN, HF
- rebound HTN = taper dose
- bronchoconstriction, bradycardia, CNS effects