FINALS: MSK Tumors Flashcards
(30 cards)
Q: What is the most common benign bone tumor in children?
A: Osteochondroma.
Q: Which tumor involves a t(11;22) translocation?
A: Ewing Sarcoma.
Q: Which benign tumor has a nidus and is relieved by NSAIDs?
A: Osteoid Osteoma.
Q: Which benign tumor is typically located in the epiphysis of long bones?
Chondroblastoma
Q: What is the classic radiographic appearance of a Unicameral Bone Cyst (UBC)?
A: Radiolucent lesion, often in proximal humerus or femur, affecting children aged 5–15.
Q: What syndrome is associated with multiple fibrous cortical defects, café-au-lait spots, and other anomalies?
A: Jaffe-Campanacci Syndrome.
Q: Which benign tumor is characterized by blood-filled spaces and can be locally aggressive?
A: Aneurysmal Bone Cyst (ABC).
Q: What is the most common malignant bone tumor?
A: Osteosarcoma.
Q: Which benign lesion is eccentric, metaphyseal, and common in adolescents?
A: Fibrous Cortical Defect (non-ossifying fibroma).
Q: What is a distinguishing histologic feature of Chondroblastoma?
A: Well-marginated lesion with potential for recurrence or rare malignancy.
Q: What is the typical radiographic finding of Ewing sarcoma?
A: Onion-skin appearance.
Q: What is the treatment for asymptomatic benign bone cysts?
A: Observation; surgery if cortical thinning or pain is present.
Q: What is the hallmark histologic feature of osteosarcoma?
A: Production of malignant osteoid.
Q: Where does osteosarcoma most commonly occur?
A: Distal femur, proximal tibia, and proximal humerus.
Q: What primary bone lymphoma type is most common?
A: Non-Hodgkin’s lymphoma.
Q: What are the three surface variants of osteosarcoma?
A: Parosteal, periosteal, and high-grade surface.
Q: Which surface osteosarcoma has the best prognosis and grows slowly?
A: Parosteal osteosarcoma.
Q: What is the typical treatment regimen for Ewing Sarcoma?
A: 6–9 months of alternating chemotherapy (VDC + IE), surgery, and/or radiation.
Q: What is the most common skeletal malignancy in adults?
A: Multiple Myeloma.
Q: What radiographic finding is classic for multiple myeloma?
A: “Punched-out” lytic lesions in skull and axial skeleton.
Q: What is the treatment approach for multiple myeloma?
A: Chemotherapy (e.g., VAD), bisphosphonates, stem transplant, radiation, surgical stabilization.
Q: What is the second most common malignant bone tumor?
A: Chondrosarcoma.
Q: What grade of chondrosarcoma has the worst prognosis?
A: Grade 3 (5-year survival ~29%).
