FINALS: Reviewer Flashcards by appyiiii <3

Which of the following is the classification of doxorubicin?
A) antifolate
B) antimetabolite
C) anthracycline
D) alkylating agent

C) anthracycline

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Which of the following agents stabilizes microtubule assembly?
A) dasatinib
B) docetaxel
C) doxorubicin
D) dacarbazine

B) docetaxel

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What is the classification of melphalan?
A) antitolate
B) antimetabolite
C) anthracycline
D) alkylating agent

A) antitolate

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Which of the following adverse effects is MOST common with cisplatin?
A) pulmonary fibrosis
C) hemorrhagic cystitis
B) nephrotoxicity
D) cardiotoxicity

D) cardiotoxicity

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Which of the following acts on the and inhibits progression at N7 of guanine?
A) oxaliplatin
C) teniposide
B) procarbazine
D) vinorelbine

B) procarbazine

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Which antineoplastic agent is CORRECTLY matched with the corresponding cell cycle phase it acts on?
A) cabazitaxel - M
B) docetaxel - G1
C) epirubicin - G2
D) fludarabine - S

A) cabazitaxel - M

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Which agent inhibits topoisomerase II?
A) bleomycin
B) etoposide
C) irinotecan
D) letrozole

B) etoposide

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Which agent targets and inhibits tyrosine kinase?
A) bevacizumab
B) dasatinib
C) doxorubicin
D) gemcitabine

B) dasatinib

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Which of the following is the indication for use of oxaliplatin?
A) acute myelogenous leukemia
B) choriocarcinoma
C.) colon cancer
D) pleurodesis

C.) colon cancer

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. Which of the following is classified as an androgen receptor blocker?
A) abarelix
B) exemestane
C) fluorouracil
d) flutamide

d) flutamide

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In a patient with advanced stage ovarían cancer combination chemotherapy will be given after the surgical
removal of the uterus, fallopian tubes, ovaries, omentum and pelvic lymph nodes. What is the purpose or role of chemotherapy?
A) adjuvant
B) concurrent
C) palliative
D) primary induction

A) adjuvant

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. Which of the following is classified as a cell cycle specific antineoplastic agent?
A) bleomycin
B) carboplatin
C) cyclophosphamide
D) doxorubicin

C) cyclophosphamide

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Which specific system is the adverse effect of busulfan MOST likely to occur?
A) cardiac
B) neurologic
C) pulmonary
D) renal

C) pulmonary

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Which agent can kill tumors in both the resting and cycling phases?
A) docetaxel
C) teniposide
B) epirubicin
D) vinorelbine

B) epirubicin

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Which of the following is TRUE regarding the log cell kill kinetics of cancer chemotherapy agents?
A) a greater proportion of cells is killed as the tumor is larger
B) at a given dose, a constant fraction of cancer cells is killed
C) a constant number of tumor cells are killed at a particular dose
D) the smaller the tumor the less number of cells killed

B) at a given dose, a constant fraction of cancer cells is killed

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Which of the following is the classification of cyclophosphamide?
A) antifolate C) anthracycline B) antimetabolite D) alkylating agent

D) alkylating agent

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Which agent acts by inhibiting topoisomerase II?
A) bevacizumab
C) etoposide
B) dazatinib
D) gemcitabine

C) etoposide

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Which of the following agents is associated with nephrotoxicity?
A) bleomycin C) paclitaxel B) cisplatin D) vincristine

B) cisplatin

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At what phase does vincristine primarily act?
A) G1 C) M B) S D) Any phase it is cell cycle non-specific

C) M

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Which of the following agents is used to promote pulmonary fibrosis?
A) 5-fluorouracil C) melphalan B) bleomycin D) oxaliplatin

B) bleomycin

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Which of the following agents crosses the blood brain barrier?
A) cyclophosphamide C) carmustine B) capecitabine D) carboplatin

C) carmustine

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Which drug class has increase in DNA repair as the mechanism for resistance?
A) antimetabolite C) platinum analogs B) akylating agents D) taxanes

B) akylating

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Which agent is indicated for colorectal cancer?
A) oxaliplatin C) gemcitabine B) melphalan D) etoposide

A) oxaliplatin

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Leucovorin is the rescue therapy for which agent?
A) cisplatin C) ifosfamide B) doxorubicin D) methotrexate

D) methotrexate

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Which of the following chemotherapy agents has cell cycle specific effects? A) bleomycin C) cisplatin B) busulfan D) epirubicin

A) bleomycin

The following drugs are inhibitors of cell wall synth A. Carbapenems B. Cephalosporins C.Macrolides D. Penicillin

D. Penicillin

Penicillin is classified as a agent A. Bactericidal B. Bacteriostatic.

A. Bactericidal

Which of the following adverse effects is classified as indirect toxicity? A. Anaphylaxis B. Bacteriostatic. C. Ototoxicity B. Oral candidiasis

B. Oral candidiasis

Anaerobes are innately resistant to aminoglycosides because intracellular accumulation is oxygen-dependent. This is an example of resistance. A. Acquired B. Innate

B. Innate

The following cell wall synthesis inhibitors inhibit peptidoglycan cross-linking EXCEPT A. Carbapenems С.Penicillin B. Cephalosporin D. Vancomycin

D. Vancomycin

Amoxicillin is classified as A. B-lactamase resistant; narrow spectrum B. B-lactamase susceptible; broad spectrum C. B-lactamase susceptible; narrow spectrum

B. B-lactamase susceptible; broad spectrum

. The MAJOR mechanism of resistance developed by most staphylococci and many gram-negative organisms against penicillin is A. Changes in porin structure B. Formation of beta-lactamases C. Structural change in target penicillin-binding proteins

B. Formation of beta-lactamases

Which penicillin is primarily used for the treatment of known or suspected staphylococcal infections? A. Amoxicillin C. Oxacillin B. Ampicillin D. Penicillin G

C. Oxacillin

The major route of elimination of cephalosporins is via excretion. A. Biliary B. Renal

B. Renal

Complete cross-allergenicity between different penicillins should be assumed A. TRUE B.FALSE

A. TRUE

The following drugs are inhibitors of cell wall synthesis: A. Carbapenems B. Cephalosporins C. Macrolides D. Penicillin

D. Penicillin (pero sabi pati din si a & b)

Penicillin is classified as a bactericidal agent: A. Bactericidal B. Bacteriostatic

A. Bactericidal

Which of the following adverse effects is classified as indirect toxicity? A. Anaphylaxis B. Bacteriostatic C. Ototoxicity D. Oral candidiasis

D. Oral candidiasis

Anaerobes are innately resistant to aminoglycosides because intracellular accumulation is oxygen-dependent. This is an example of innate resistance: A. Acquired B. Innate

B. Innate

The following cell wall synthesis inhibitors inhibit peptidoglycan cross-linking EXCEPT: A. Carbapenems B. Cephalosporin C. Vancomycin D. Penicillin

C. Vancomycin

Amoxicillin is classified as: A. B-lactamase resistant; narrow spectrum B. B-lactamase susceptible; broad spectrum C. B-lactamase susceptible; narrow spectrum

B. B-lactamase susceptible; broad spectrum

This long acting bronchodilator can be given as controller medication for bronchial asthma. A. Albuterol B. Formoterol C. Metaproterenol D. Terbutaline

B. Formoterol

The major mechanism of resistance developed by most staphylococci and many gram-negative organisms against penicillin is: A. Changes in porin structure B. Formation of beta-lactamases C. Structural change in target penicillin-binding proteins

B. Formation of beta-lactamases

Which penicillin is primarily used for the treatment of known or suspected staphylococcal infections? A. Amoxicillin B. Oxacillin C. Ampicillin D. Penicillin G

B. Oxacillin

This corticosteroid can be given for bronchial asthma management. A. Aminophylline C. Cromolyn B. Budesonide D. Theophylline

B. Budesonide

Mechanism of action of this anti-inflammatory agent is through inhibition of cytokine gene expression and phospholipase A2. A. Antimuscarinic agent B. Corticosteroid C. Methylxanthine D. Leukotriene receptor antagonist

B. Corticosteroid

This is considered a non-selective beta agonist. A. Epinephrine B. Phenylpropanolamine C. Salbutamol D. Salmeterol

A. Epinephrine

This drug enhances bronchodilation by inhibiting the phosphodiesterase (PDE) enzyme located in bronchial smooth-muscle cells. A. Cromolyn B. Fluticasone C. Theophylline D. Tiotropium

C. Theophylline

This is a systemic corticosteroid used to treat acute asthma attack. A. Beclomethasone B. Budesonide C. Flunisolide D. Prednisone

D. Prednisone

This drug is given to address upper respiratory tract infection. A. Carbocisteine B. Cromolyn sodium C. Methylprednisolone D. Montelukast

A. Carbocisteine

he mechanism of action of this asthma drug is through inhibition of leukotriene receptors. A. Betamethasone B. Cromolyn C. Montelukast D. Tiotropium

C. Montelukast

A 22 year old female being treated for bronchial asthma attack was given an inhalational agent. The patient then developed tremors after. What agent may have caused this? A. Albuterol B. Dexamethasone C. Nedocromil D. Zafirlukast

A. Albuterol

A 67 year old male came in due to COPD exacerbation. He was given an inhalational agent which afforded relief of difficulty of breathing. However, the patient developed urinary retention and dry mouth. What agent may have caused this? A. Albuterol B. Ipratropium C. Salmeterol D. Terbutaline

B. Ipratropium

Complete cross-allergenicity between different penicillins should be assumed: A. TRUE B. FALSE

A. TRUE

1st-generation cephalosporins are used primarily against gram-positive cocci with minimal gram-negative activity: A. 1st B. 2nd

A. 1st

The major route of elimination of cephalosporins is via renal excretion: A. Biliary B. Renal

B. Renal

When combined with ethanol, cefamandole can cause a disulfiram-like reaction: A. Acetaminophen B. Diazepam C. Disulfiram D. Ketamine

C. Disulfiram

This beta-lactam antibiotic is a safe alternative for patients with penicillin or cephalosporin allergy but has no activity against gram-positive bacteria: A. Aztreonam B. Bacitracin C. Daptomycin D. Meropenem

A. Aztreonam

Which of the following acts as suicide inhibitors of bacterial penicillinases? A. Clavulanic acid B. Colistin

A. Clavulanic acid

This is the drug of choice for MRSA and is associated with red man syndrome: A. Cycloserine B. Ertapenem C. Fosfomycin D. Vancomycin

D. Vancomycin

Inhibits phosphorylation/dephosphorylation cycling

Bacitracin

Blocks incorporation of d-Ala into the pentapeptide side chain of the peptidoglycan

Cycloserine

T or F Daptomycin Causes membrane depolarization, forming transmembrane channels

TRUE

T or F Fosfomycin Inhibitor of cytosolic enolpyruvate transferase

TRUE

T or F Vancomycin Inhibitor of cytosolic enolpyruvate transferase

FALSE Vancomycin - A (Binds to the d-Ala-d-Ala terminal of the nascent peptidoglycan pentapeptide side chain, inhibiting transglycosylation)

FINALS: Reviewer Flashcards

(70 cards)