Finding New Targets Flashcards
(7 cards)
1
Q
Druggable classes
A
- TTM GPCRs
- proteases
- kinases
- nuclear receptors
- ion channels
- integrins
2
Q
Good drug targets
A
- functional rather than structural proteins
- can be modulated
- can set up an assay
- chemical tractibility
- strong rationale for disease link
- ability to separate desirable vs undesirable effects
- demonstrate efficacy in clinical setting
- market for drug
3
Q
Susceptibility genes
A
Natural polymorphisms can increase the likelihood of certain diseases
Act in combination with other susceptibility genes
4
Q
Animal models (e.g. ADHD)
A
Animal models used to test new targets; must recapitulate aspects of human disease
e.g. ADHD
- spontaneously hypertensive rat as a model
- main symptoms of impaired attention and hyperactivity
- human ritalin treatment also works in SHR
5
Q
Known drugs
A
Known drugs can act as guides for new drugs
e.g. original antipsychotics have motor side effects so new antipsychotics have reduced D2 affinity but increased activity at other sites (e.g. 5-HTRs) to combat other symptoms
6
Q
Disease pathway targeting in asthma
A
- avoid allergen exposure
- vasodilators
- steroids
- chemotaxic receptor blockers
- novel anti-inflammatoriees
7
Q
Methods of finding new targets
A
- disease genetics + susceptibility genes
- disease pathways
- druggable protein classes
- animal models
- known drugs
