First Indigenous mRNA Vaccine Technology Flashcards
name some covid vaccines developed indigenously and globally
indigenous: Covaxin, ZyCoV-D
globally: Sputnik V, Covishield
ZyCoV-D by
by Zydus (a
pharmaceutical company) with support from
the DBT.
Covaxin by:
by Bharat Biotech in
collaboration with the ICMR.
Covishield:
Name given to an Oxford-AstraZeneca
Covid-19 vaccine candidate which is technically
referred to as AZD1222 or ChAdOx 1 nCoV-19.
Sputnik V:
The first vaccine to be officially registered
and has been developed by Moscow’s Gamaleya
Institute in collaboration with Russia’s defence
ministry.
Why in news?
(CSIR-CCMB) has
announced the success of ‘proof of principle’ of the first
indigenous Messenger RNA (mRNA) vaccine technology.
researcher says it’s ready for it to be taken over by some company for human trials and markets after regulation and approval.
is it same as the mRNA vaccine being developed by Gennova Bio based on self-replicating RNA.
This is different from the mRNA vaccine being developed
by Gennova Bio based on self-replicating RNA.
Proof of Principle aka proof of concept
it is feasible and practical
mRNA
mRNA, or messenger RNA,
which is the molecule that essentially puts DNA
instructions into action. Inside a cell, mRNA is used
as a template to build a protein.
mRNA vaccine tech used
use mRNA to teach our cells how
to make a protein or a protein that triggers an
immune response inside our bodies. That immune
response, which produces antibodies, is what
protects us from getting infected if the real virus
enters our bodies.
The researchers developed indigenous potential
mRNA vaccine candidate against??
SARS-CoV-2.
the indig mRNA vaccine is based on which model
It is based on the Moderna model, but has been
built with the information available in the open
and indigenous technology and materials.
Significance of the indig mRNA vaccine
various COVID variants and other infectious diseases
such as Tuberculosis, Dengue fever, Malaria,
Chickungunya, Rare Genetic diseases and others.
Efficacy of the vacc:
“Robust immune response” has been observed
against the Covid-19 spike protein in mice upon
administration of two doses of the mRNA.
The anti-spike antibodies generated were found
to be more than 90% efficient in preventing the
human ACE2 receptor binding to the coronavirus
human ACE2 receptor
Angiotensin converting enzyme 2 (ACE-2), known as ACEH (ACE homolog), is an integral membrane protein.
ACE-2 serves as the receptor for the SARS-CoV and SARS-CoV-2 viruses.
It provides the entry point for the coronavirus to hook into and infect a wide range of human cells.
