Fits - Drugs For Gout

Question 1

Uric acid reuptake inhibitor

Answer 1

Probenecid

Question 2

xanthine oxidase inhibitors

Answer 2

Allopurinol, febuxostat

Question 3

Use in advanced gout that is refractory to other (uricosolytics)

Answer 3

Pegloticase, rasburicase

Question 4

Gout specific anti-inflammatory

Answer 4

Colchicine

Question 5

T1/2 of active metabolite of allopurinol

Answer 5

Oxypurinol - 16 hrs, dive qd PO

Question 6

XO inhibitor that can be used in ptz with renal dz

Answer 6

Febuxostat

Question 7

Pts who are starting ULT should also be started on ___________ to avoid acute gout attack

Answer 7

Oral colchicine or NSAIDs

Question 8

HSN to allopuriol

Answer 8

Ppl with HLA-B*5801 genotype - sen in Han Chinese and thai descent

Question 9

Target of probenecid

Answer 9

URAT1

Question 10

Drugs that can exacerbate uric acid accumulation

Answer 10

Asa - inhibite urate excretion, thiazide and loop diuretics - dehydrates pt

Question 11

Frontline anti-inflammatories used in gout tx

Answer 11

NSAIDS, colchicine, corticoids

Question 12

tx in the case of tumor lysis syndrome

Answer 12

peglodicase