FM other Flashcards
What is the most sensitive test for alcohol abuse? Most specific?
- sensitive: GGT
- specific: MCV
What DM drug is safer to use with a creatinine > 1.5 ?
-thiazolidinediones
What is HTN in arms, but low bp in the legs a sign of?
- coarctation of the aorta
- more than 50% of the pts w/ coarctation of the aorta also have bicuspid aortic valaves
What BMI is extreme obesity (class III obesity)?
- > 40
What BMI is overweight?
> 25
What percentage of total units should be long acting?
-40-50% (ex lantus)
Tx of choice for premature ejaculation?
-SSRIs bc they increase threshold for orgasm
Mild intermittent asthma sx?
- sx less than 2 times a week
- night time sx less than 2 times a month
Loosing weight and HTN?
-10 lbs lost usually means 20mmHg decrease in systolic bp
Anginal equivalent
-a pt has no chest pain, but has other sx of cardiac ischemia (ex dyspnea) that is brought on by exertion and relieved by rest
Whatis the only tx found to improve the natural history of COPD progression?
-supplemental oxygen
What are the ABCDs of treating HTN?
- A = ACEi –> should be used as first line tx in all pts younger than 55 or are black
- B = beta blocker –> can be used, but not are not ideal first-line
- C = CCB –> first line tx for pts older than 55 &/or black
- D = diuretics –> also can be used as first line tx in pts who are older than 55 &/or black
- if mono tx is not working add another from a diff category (ex. A or B + C or D)
- if still need more control add another from a diff category (ex. A (or B) + C + D)
What is the recommended first line monotx to prevent occurrence of CV morbidity and mortality?
-low-dose diuretic
Target LDL for pts w/ known CAD or DM?
-less than or equal to 70
What drug has been proven to be the best for advanced Alzheimer’s dementia?
-memantine
What BMI is class II obesity?
- > 35
What is the lipid lowering mechanism of fish-oil?
-decreases the secretion of TGs by the liver
First line tx for COPD?
-An inhaled anticholinergic = (ipratropium
When should pap smears be done in HIV positive pts?
-every 6 mnths
Which 2 cholesterol med increases HDL the most? Rank?
- Niacin (25-35%)
2. Fenifibrates (15-25%)
sitagliptin: MOA?
- AKA: januvia
- dipeptidyl peptidase-4 (DPP-4) inhibitor = prolongs activity of endogenously released GLP-1 = dtimulates insulin and suppresses glucagon secretion, delays gastric emptying, reduces appetite
What are the 2 most commonly reported sx of hyperTH?
- Tachycardia
2. Fatigue
Hypoesthesia
-numbness
Ezetemibe: MOA?
- AKA: Zetia
- lowers the cholesterol by interfering w/ absorption of cholesterol in the gut
- good to use in combo with statins to get max decrease in LDL without all the side effects of high doses of statins
Of all the lipid values, which is the best predictor of an adverse outcome? What is the most effective way to improve that number?
- low HDL = worse
- can improve the most w/ exercise
Paresthesia
-pins and needles
MOA of naltrexone with alcohol abuse?
- reduce the reinforcing effects of alcohol
- doesnt allow the pt to become “drunk”
How will smoking cessation effect a pts lipid levels?
- increase HDL by 5-10 mg/dL
- does NOT affect LDL, VLDL, or TGs
Complication rate with bariatric surgeries?
-40%
What should be done after an HIV positive needle stick?
- Determine vicitm’s HIV viral load level
2. Start using at least 2 medications for prophylaxis
Which 2 antidepressants should not be used in obese patients?
- Mirtazapine
2. Tricyclic antidepressants
Which antidepressants should not be used in patients with a seizure disorder?
-buproprion
Gemfibrozole: MOA?
- changes hepatic metabolism of lipoproteins
- can increase HDL and decrease TGs
What is the first lab abnormality seen in chronic renal failure?
- anemia, the kidneys epo production drops when the GFR is below 60
- other results, such as hyponatremia, hyperkalemia, etc wouldnt be seen until function drops below 30
Which 2 antidepressants should not be used in pts with agitation and insomnia?
- Bupropion
2. Venlafaxine
What are 3 contraindications for a stress EKG? Why? What test should be done in its place?
- Left ventricular hypertrophy with strain
- Left bundle branch block
- ST-segment baseline abnormaliities in the pre-cordial leads
- these EKG abnormalities make the stress test EKG hard to read
- use: thallium exercise test instead
Obesity and osteoporosis?
- obesity is considered to be protective –> bc increased estrogen
- unless the person is sedentary
Drug if choice to prevent relapse of alcoholism?
-Acamprosate
How do you determine what a low dose of NPH will be?
-0.1 U/kg of body weight
Peak flow measurements of what require immediate medical attention?
- < 50%
What is stage 2 HTN? Tx?
- systolic > 160
- OR diastolic > 90
- tx:two-drug combination tx (usually thiazide + ACEi, ARB, Bb, or CCB)
Drug of choice for hyperlipidemia in diabetics?
-statins
Tx for a pt started on an antidepressant that becomes manic?
- neuroleptic for the acute phase
2. Then a mood stabilizer
What dosage of beta blocker should be used for angina?
- dosage should be adjusted so that the heart rate is between 50-60 bpm
- not all pts will respond to Bbs
- all Bbs are essentially the same
Bisphosphonates: MOA?
-bind to bone surface and inhibit osteoclast activity
What antidepressant should not be used in pts w/ HTN?
-venlafaxine
Spondylolisthesis
- anterior displacement of vertebrae in relation to the one below
- most common cause of low back pain in patients younger than age 26
- especially seen in athletes
What is the target LDL with a 10 yr coronary disease risk > 20%? 10-20%?
- > 20% = < 100
- 10-20% = < 130
- <10% = < 160
Which 2 antidepressants should be avoided in pts with hypersomnia and motor retardation?
- Nefazodone
2. Mirtazapine
What 3 tests should be done in a child who is suspected to have ADHD?
- Blood chemistries
- TSH
- Lead level
What tx is recommended to prevent recurrent strokes?
-ACEi plus diuretic
What BMI is obese?
- > 30
Which 2 cholesterol meds decrease the TGs the most? Rank?
- Fenofibrate
2. Statins
5 absolute contraindications to liver transplant?
- Portal vein thrombosis
- Severe medical illness
- Malignancy
- Hepatobiloary sepsis
- Lack of patient understanding
Mild persistent asthma sx?
- sx more than 2x per week, but less than once a day
- night time sx more than 2x per month
Selective estrogen receptor modulators: MOA? Name 2?
- MOA: block the activity of cytokines
1. Raloxifene
2. Evista
Fluoride: MOA
-stimulates osteoblasts –> but doesnt result in normal bone to be formed
What is the most common cause if death in patients with cirrhosis?
-bleeding from varicies secondary to chronic high pressures in portal veins
Hyperesthesia
-increased sensitivity
Peak flow measurements of what mean the asthma tx should be reevaluated?
-50-80%
What drug can be used for osteoporosis tx and for bone pain?
-calcitonin
Moderate persistent asthma sx?
- daily sx
- night time sx at least once a week
Allodynia
-severe pain, usually from innocuous stimuli
What antidepressant should not be used in pts with liver dz?
-nefazodone
Tx of PTSD? 2 best drugs?
- antidepressants should be used
1. Sertraline
2. Paroxetine
Describe the pain associated with esophageal spasm
-often referred higher in the chest
Croup tx?
- uncomplicated = supportive
- more complex, severe = single dexamethasone
What is BI-RADS?
- breast imaging reporting and data system
- 0 = test incomplete, additional testing should be done
- 1&2 = mammogram is benign, routine screening can be done at regular intervals
- 3 = lesion is probably benign
- 4 = suspicious for cancer, tissue dx is needed
- 5 = highly suggestive of cancer, tissue dx is needed
What 3 ssx should be present to make a dx of otitis media?
- Opaque TM
- Bulging TM
- Impaired TM mobility
Fatigue due to psychologic factors?
- lasts more than 3 mnths
- causes:
1. Depresssion
2. Anxiety
3. Stress
4. Adjustment rxns
What are the 5 Ranson’s criteria that assess the severity and prognosis of pancreatitis?
- Age > 55 yrs
- WBC > 16,000
- Glucose > 200
- LDH > 350
- AST > 250
Tx of choice of tinea capitis?
- griseofulvin
- can also use selenium or ketoconozole topically in addition
Tx for shoulder dislocation
- relocation
- then immobilization for 7-10 days
- then PT
What is the tx of choice for chronic constipation? What is it?
- psyllium
- bulk-forming agent
- can be taken regularly
Physiologic causes of fatigue?
- Overwork
- Lack of sleep
- Physical stressor (ex pregnancy)
Primary monosymptomatic enuresis?
- bed wetting w/ out history of not bed wetting
- no other sx
What should be done next when a papsmear reports “atypical squamous cells of undetermined significance, favor low-grade squamous intraepithelial lesion”?
-do colposcopy
Exotropria
-eye deviates toward temporal side
Fatigue due to a physical cause?
- lasts less than 1 mnth
- can be due to:
1. Infections
2. Endocrine imbalances
3. CV dz
4. Anemia
5. Meds
What 6 tests should be done in the initial workup for fatigue?
- CBC
- Sed rate
- Urinalysis
- Chem panel
- Thyroid testing
- Preg testing
- Age/gender appropriate cancer screening
7 Red flags for headaches?
- Onset after age 50
- Very sudden onset
- Increased severity or frequency
- W/ signs of systemic dz
- Focal neurologic sx
- Papilledema
- Headache after trauma
Antibiotic tx for lyme dz?
- depends on stage of the dz
- early localized dz = amoxicillin or doxy for 14-21 days
- early disseminated dz = IV ceftriaxone or cefotaxime for 2-3 wks
What is the Dix-Hallpike maneuver? What do the results mean?
- distinguishes central from peripheral vertigo
- have patient sit on the edge of the examining table and lie down suddenly with the head hanging 45° backward –> turned head to either side
- Peripheral: latency for onset of sx of nystagmus is 3-10 sec, the sx are severe, and the direction of the nystagmus is fixed, also sx should lessen when the maneuver is repeated
- Central: no latency to onset of sx, no lessening of sx with repeat of maneuver, the direction of nystagmus will change, sx are of mild intensity
When is rhogam given?
-26-28 weeks
What is cervical dystonia? What is a proven tx?
-botox!
Which tx for Parkinson’s has been found to delay functional impairment and disease progression?
-selegiline = MOA inhibitor
What are the 6 “alarm sx” of constipation?
- Hematochezia
- Family hx of colon cancer
- Family hx of IBS
- Positive fetal occult blood test
- Weight loss
- New onset of constipation in pts > 50
Presentation of ACL tear?
- twisting injury where the pt feels a “pop”, then immediate effusion
- can still bear weight
- instability
Tx of cat bite to the hand?
- hospitalization!! Unless it is very superficial and does not appear to be infected
- outpatient tx: amoxicillian/clavulanic acid, 5 days for prevention & 10 days for tx
- do not ever close the bite at first!!
What is he gold standard for dx and tx of choledocholithiasis?
- Endoscopic retrograde cholangiopancreatography (ERCP)
- performed when there is cholycystitis w/ increased liver enzymes, amylase, or lipase
High AFP?
-neural tube defect
Bacteria that causes impetigo?
-staph aureus
What is a D-dimer test for?
- determines the risk for a DVT or PE
- low result = high neg predictive value for the presence of a thrombus
- high result –> can be confirmed with spiral CT