FMS Summative Exam 1: Main Material Flashcards Preview

FMS > FMS Summative Exam 1: Main Material > Flashcards

Flashcards in FMS Summative Exam 1: Main Material Deck (15):
1

tight junctions

seals the gap between epithelial cells. Apical side. Use claudins and occludins.

2

adherens junctions

connects actin filament bundles of adjacent cells. Made cadhedrins and catenins. Ca2+ dependent.

3

desmosomes

same as adherens but instead connects intermediate filaments. P. vulgaris= desmosomes

4

gap junctions

allow the passage of small water soluble molecules from one cell to the next. Key protein= connexin. not found in muscle.

5

JAK/STAT Pathway

JAK=> autophos. STAT=> phos. Dimerization => Activate TF in nucleus. Deals with hematopoetic cell proliferation.

6

RAS/MAPK

TyrK receptor => Associated proteins => Ras => Rak => MEK=> ERK => TFs. Cell growth and proliferation.

7

PI3K/ AKT

TyrK receptor, binds to peptide hormones,=> IRS=> PIP2=> PIP3=> PDK1=> AKT

8

cAMP/ PKA

7transm receptor=> Gprotein=> adenylate cyclase=> cAMP=> PKA

9

IP3/PKC

7transm receptor=> Gprotein=> Phospholipase C=> IP3+DAG=> Smooth ER=> Ca2+=> PKC

10

Difference between channels and pumps

Channels are mechanisms of passive diffusion. Pumps indicate active transport against concentration gradients.

11

ABC transporters and cancer

ATP Binding Cassette (ABC) Transporters use ATP and hydrolysis to move ligands from inside the cell out to the extracellular space and are one major cause of tumor resistance to chemotherapeutic agents.

12

Transport path from a mRNA to plasma membrane protein.

Integral+ secreted proteins synthesized on ER bound ribosomes. growing peptide has signal peptide. Signal recognition peptide binds and guides to receptor near translocon on RER. completed polypeptide pooped into RER cisterna.

13

Describe the effect of insulin on blood glucose level and how each organ responds.

Fed state receptor. Produced by beta cells in pancreas. Glut2 receptors on pancreas take in glucose which causes Ca2+ into cell and depolarization. This releases insulin. In muscle cells AKT pathway cascades to allow Glut4 to arrive on the surface of cells and intake glucose. This in turn drops glucose levels.

14

Glucagon

Fasting state receptor. produced by the liver when senses low blood glucose. initiates the dumping of glucose stores into blood stream. raise bgl

15

What are the repair pathways?

mismatch, BER, NER, homologous repair, end-joining.