Flashcards in FMS Summative Exam 1: Main Material Deck (15):
seals the gap between epithelial cells. Apical side. Use claudins and occludins.
connects actin filament bundles of adjacent cells. Made cadhedrins and catenins. Ca2+ dependent.
same as adherens but instead connects intermediate filaments. P. vulgaris= desmosomes
allow the passage of small water soluble molecules from one cell to the next. Key protein= connexin. not found in muscle.
JAK=> autophos. STAT=> phos. Dimerization => Activate TF in nucleus. Deals with hematopoetic cell proliferation.
TyrK receptor => Associated proteins => Ras => Rak => MEK=> ERK => TFs. Cell growth and proliferation.
TyrK receptor, binds to peptide hormones,=> IRS=> PIP2=> PIP3=> PDK1=> AKT
7transm receptor=> Gprotein=> adenylate cyclase=> cAMP=> PKA
7transm receptor=> Gprotein=> Phospholipase C=> IP3+DAG=> Smooth ER=> Ca2+=> PKC
Difference between channels and pumps
Channels are mechanisms of passive diffusion. Pumps indicate active transport against concentration gradients.
ABC transporters and cancer
ATP Binding Cassette (ABC) Transporters use ATP and hydrolysis to move ligands from inside the cell out to the extracellular space and are one major cause of tumor resistance to chemotherapeutic agents.
Transport path from a mRNA to plasma membrane protein.
Integral+ secreted proteins synthesized on ER bound ribosomes. growing peptide has signal peptide. Signal recognition peptide binds and guides to receptor near translocon on RER. completed polypeptide pooped into RER cisterna.
Describe the effect of insulin on blood glucose level and how each organ responds.
Fed state receptor. Produced by beta cells in pancreas. Glut2 receptors on pancreas take in glucose which causes Ca2+ into cell and depolarization. This releases insulin. In muscle cells AKT pathway cascades to allow Glut4 to arrive on the surface of cells and intake glucose. This in turn drops glucose levels.
Fasting state receptor. produced by the liver when senses low blood glucose. initiates the dumping of glucose stores into blood stream. raise bgl