FMS Week 9: Regeneration and Repair Flashcards Preview

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Flashcards in FMS Week 9: Regeneration and Repair Deck (29):
1

Causes of Tissue Injury

8 Listed

2

Tissue Adaptations

4 Listed

  • Hyperplasia
  • Hypertrophy
  • Atrophy
  • Metaplasia

3

4

What do you see?

  • Stratum corneum destroyed
  • neutrophils (forbidden this is acute process)

5

What do you see?

neutrophils in the epithelium (forbidden than is an acute process)

6

Integrins action

signal transduction that there is damage taking place

what is the signal saying?

7

What is this and its significance in injury?


The basement membrane divides to replace dying cells from damage detected by integrin signaling

8

Macrophage Growth Factors

4 Listed

  • EGF
  • TGF-α
  • FGFs
  • TGF-β

9

What are these cells?

  • showing keratinocytes
  • macrophage bot left
  • top right fibroblast

10

What is the chance there will be regeneration here?

6 Listed

  • None
  • very necrotic
  • no cells left
  • angiogenesis will take place
  • macrophages and mesenchymal will come in VEGF, FGF
  • fibroblasts lay down collagen and scar formation

11

What do you see?

granulation tissue

blood vessels

fibroblasts 

construction site

12

What do you see?

  • granulation tissue
  • blood vessels
  • fibroblasts 
  • construction site

13

scar

14

15

How is collagen made?

need vitamin C for tissue repair

16

Tissue Examples based on proliferative capacity

3 Listed

  • Permanent Tissues
  • Stable Tissues
  • Labile Tissues

17

Permanent tissues Properties

3 Listed

18

Permanent Tissue Examples

2 Listed

  • Neurons
  • Cardiac Muscle Cells

19

Stable Tissues Properties

6 Listed

20

A Stable tissue that can divide?

Liver Cells

21

Stable Tissues Cell Cycle

Tend to be quiescent in G0 but can go back into the cell cycle

22

Labile Tissues Properties

4 Listed

23

Labile Tissue Examples

3 Listed

  • Hematopoietic cells of bone
  • Surface epithelia
  • Gastrointestinal columnar epithelium

24

Stem Cell Homeostasis

25

Stem Cell Self-renewal

permits stem cells to maintain their numbers

26

Stem cell asymmetric division

one daughter cell enters a differentiation pathway and gives rise to mature cells, while the other remains an undifferentiated and retains its self renewal capacity

27

Quality or adequacy of tissue repair may be negatively affected by?

6 Listed

28

First Intention Properties

3 Listed

29

Second intention Properties

6 Listed