Folding Funnel - Energy landscape

Question 1

What guides protein folding?

Answer 1

the folding funnelw

Question 2

what is the folding funnel

Answer 2

This is an energy landscape that describes how proteins are guided down a preferred path of folding from its unfolded high energy state down towards its low energy native conformation.

Question 3

True or false. protein all fold according to the same filing funnel or energy landscape.

Answer 3

False. Each protein has its own energy landscape/folding.

Question 4

Why is the folding funnel important?

Answer 4

If a protein had to try and fold into all possible conformation until it found its correct one, folding would take too long, protein would not function in conjunction with demand of life so life would not be possible.

Question 5

What are the four classical theories of folding?

Answer 5

1. Secondary structure formation
2. hydrophobic collapse
3. nucleation-condensation
4. nucleation propagation

Question 6

Secondary Structure formation theory

Answer 6

secondary structures of the protein form and all diffuse towards each other/collide to form the structure.

Question 7

Hydrophobic collapse

Answer 7

hydrophobic forces cause the structure to collapse and form an intermediate globule that then rearranges as needed.

Question 8

nucleation-condensation

Answer 8

A small, stable nucleus the native stricture forms first and the rest of the folding condenses around this nucleus.

Question 9

Nucleation-propagation

Answer 9

small residues come together to form a small-stable native like structure. Once the happens interaction spread that bring the protein together quickly.