FOM anki flashcards week 2
(43 cards)
What is the polarity of water?
Unequal electron sharing between hydrogen and oxygen leads to a dipole (partially positive H, partially negative O).
What structure does water have?
Water has a bent structure (tetrahedral bonding angle).
What are hydrogen bonds?
Bond between hydrogen (positive) and oxygen (negative) or other electronegative atoms. Essential for water’s properties.
How does the hydrophobic effect work?
Non-polar molecules aggregate in aqueous solutions (e.g., micelles, lipid bilayers).
Define amphipathic molecules.
Molecules with both hydrophilic and hydrophobic regions (e.g., phospholipids in cell membranes).
What is the primary function of cell membranes?
Selective barrier to the external environment, involved in signaling, transport, and recognition.
What is the basic structure of amino acids?
Alpha carbon bonded to amino group (-NH₂), carboxyl group (-COOH), hydrogen, and R group (side chain).
Classify amino acids.
Non-polar (hydrophobic), Polar (hydrophilic), Acidic (negative charge), Basic (positive charge).
How are peptide bonds formed?
Peptide bonds form through dehydration between amino acids, with partial double bond character.
Define protein primary structure.
Linear sequence of amino acids forming a polypeptide chain.
Describe the secondary structure of proteins.
Local folding of polypeptide backbone (alpha helix, beta-sheet, triple helix).
How is tertiary structure stabilized?
By hydrogen bonds, disulfide bridges, ionic interactions, and hydrophobic interactions.
What causes protein denaturation?
Disruption of secondary, tertiary, and quaternary structures due to heat, pH extremes, or chemicals.
Describe the quaternary structure of proteins.
Arrangement of multiple polypeptide subunits into a functional protein (e.g., hemoglobin).
What is the role of enzymes?
Biological catalysts that lower activation energy and increase the rate of biochemical reactions.
Describe Michaelis-Menten kinetics.
Relates reaction rate to substrate concentration, with Km (half-maximal velocity) and Vmax (maximum rate).
What are the types of enzyme inhibition?
Competitive, non-competitive, and uncompetitive inhibition.
What is the pH scale?
Measures H⁺ ion concentration, with pH = -log[H⁺].
What does the Henderson-Hasselbalch equation describe?
Relates pH, pKa, and the ratio of acid to conjugate base concentrations.
Explain the function of buffers.
Resist changes in pH by neutralizing added acids or bases.
What is the isoelectric point?
pH at which an amino acid or protein has no net charge.
How is oxygen transported in the blood?
Oxygen diffuses into blood in the alveoli, and hemoglobin carries it to tissues.
Describe the structure of cell membranes.
A lipid bilayer with proteins and carbohydrates, containing amphipathic lipids.
What is the role of the lymphatic system?
Transport excess fluid (lymph) and foreign bodies to lymph nodes for immune defense.