food reactions

Question 1

prevalence of gluten and wheat-related

disorders

Answer 1

20% total for all gluten/wheat reactions

Question 2

Prev of NCGS

Answer 2

6% of population in U of Maryland study (~ 6K pts)
• Clinical experience may suggest up to 10-20% of
population

Question 3

Prev of wheat allergy

Answer 3

Worldwide, wheat allergy affects between
0.5-0.9% of the population.
In the US, 0.4% of adults report an allergy to
wheat diagnosed by a doctor.

Question 4

Prev of celiac disease

Answer 4

1% in US

30% of the general population has a genetic susceptibility, but only 3% will develop celiac disease.

Question 5

which is better for anti-gliadin - IgA or IgG?

Answer 5

IgG

Question 6

rates of IgA deficiency in celiac

Answer 6

5x more common

Question 7

anti-gliadin also high in

Answer 7

bipolar

Question 8

anti-gliadin also sign of increased

Answer 8

all-cause mortality

Question 9

best test

Answer 9

anti-TTG

Question 10

elevated liver enzymes could also be sign of

Answer 10

celiac

Question 11

CD vs. NCGS

Answer 11

adaptive vs. innate immune system

Celiac: also auto-immune, malabsorption, inflammatory

Question 12

lab test for gluten sens

Answer 12

none!

do elim diet

Question 13

best tests for celiac

Answer 13

Total IgA
• IgA/IgG tissue transglutaminase (tTG) antibody
• IgG/IgA Deaminated antigliadin (DGP) antibody
• IgA anti-endomysial antibodies (EMA)
– REFLEX if DGP IgG or tTG IgA positive