Food Safety11-1: final Flashcards

1
Q

Foodborne Diseases

A

Foodborne Diseases, are diseases acquired through the consumption of contaminated food.

~Frequently & inaccurately referred to as food poisoning.

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2
Q

Foodborne Outbreak

A

Foodborne Outbreak, is the occurrence of a similar illness among two or more people which an investigation linked to consumption of a common meal or food items.

~IN THE CASE OF BOTULISM, ONE CASE IS CONSIDERED AN OUTBREAK.

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3
Q

Foodborne diseases factors:

A

Foodborne diseases are a major cause of morbidity (& occasionally mortality) in the U.S. & other countries of the world.
Incidence of foodborne illnesses have increased in industrialized nations.
An important responsibility of local & federal government agencies is to assure the quality of food & food products.
In U.S., CDC has the responsibility at a federal level for surveillance of foodborne outbreaks.

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4
Q

Foodborne illnesses in the U.S. : Contributing factors

A

-Changes in agricultural & food processing methods.
-Globalization of food distribution.
-Social & behavioral changes among the human population.

-The CDC estimates that every 48 million people are affected by foodborne diseases.
-128,000 are hospitalized and 3,000 deaths annually.
-Incurs an economic cost of $5 billion annually.

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5
Q

U.S. surveillance of food illness:

A

CDC Foodborne Diseases Active Surveillance Network (FoodNet)

-Active system whereby public health officials maintain frequent direct contact with clinical laboratory directors to identify new cases of foodborne illnesses.

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6
Q

FoodNet surveillance : Burden of Illness Pyramid
SLIDE 7

A
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7
Q

Four Major Categories of Food Hazards

A

Food Contaminant, any impurity or substance that pollutes food.
-An agent of contamination accidentally or inadvertently introduced into food, water, or soil, that may or may not be harmful or potentially poisonous.

1) Biological: microorganisms, toxins
2) Physical: stone, glass, metal
3) Chemical: mercury, methanol
4) Nutritional: presence of nutrients & other food constituents in excessive or deficient amount that lead to disease.

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8
Q

You can usually tell if food is poisoned by smell, look, or taste?

TRUE or FALSE

A

FALSE,

can not tell

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9
Q

Foodborne Diseases: Biological Hazards

A

(1) Mycotoxin
(2) Bacterium
(3) Virus
(4) Parasites

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10
Q

Mycotoxins

A

-Substances naturally produced by fungi that contaminate crops.
-Can occur during cropping season, also during crop storage.

Crops contaminated with mycotoxins;
Corn, rice, peanuts, sorghum, soybeans, millet, rye, wheat, barley, brazil nuts, pecans, pistachios nuts, spices, walnuts, or products made from these crops.

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11
Q

Aflatoxicosis

A

-Potent toxin produced by the fungus, Aspergillus Flavus.
-Toxin-producing mold growing under high humidity & temperature conditions.
-Humans become sick by consuming unsafe levels of aflatoxin from; 1) contaminated food. 2) contaminated products.

-Potent carcinogenic & immunosuppressive effects.
-Aflatoxin contamination of foods = global human & animal health problem.
-Malnutrition & other factors can reduce ability of human body to cope with mycotoxin exposure.

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12
Q

Aflatoxin : Exposure

A

Acute: exposure to large doses =acute toxicity with lethal effects.
-Liver necrosis & death, jaundice.
-Negative impact on carbohydrates & lipid inhibition, & proteins synthesis.
Blood clotting derangement: Decreased essential serum proteins, edema of lungs & lower extremities, abdominal pain, vomiting, convulsions, & coma.
Chronic: small doses for prolonged periods is carcinogenic.
Liver damage, jaundice, swollen gall bladder, immunosuppression, and decreased vitamin K bioactivity.
(Evidence from China & Africa aflatoxins & hepatitis B virus act synergistically in etiology of liver cancer.

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13
Q

Aflatoxin: Chronic Exposure

A

Aflatoxin epidemics in humans:
3rd world countries, large outbreaks due to the lack of regulatory measures & high exposure levels.
-U.S. no reported large human outbreaks.
-Most server recent outbreaks; NW India (1974), 25% of exposed population died after ingestion of moldy corn wit aflatoxin levels ranging from 6,250-15,600 mg/kg.

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14
Q

Ergot (Claviceps Purpurea) Ergotism or “St. Anthony’s Fire”:

A

-Caused by toxic doses of alkaloid ergotamine.
-Produced by purple masses of spores on grains of spores grains that are infected by (Claviceps Purpurea).
-Spores (sclerotia)

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15
Q

Major symptoms of Ergot (Claviceps Purpurea) Ergotism or “St. Anthony’s Fire”;

A

Toxin causes vasoconstriction with severe neurological alterations.
When consumed in bread.
-Violent muscle contractions
-Vomiting
-Deafness
-Blindness
-Hallucinations
High levels of toxin cause:
Gangrene with burning pain in body extremities. Convulsions, hallucinations , severe psychosis, & death, as well as miscarriages.

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16
Q

St. Anthony’s Fire: More recent event

A

Pont-St. Esprit, France (1951) outbreak.

Small town, everyone bought bread from it. People developed burning sensation in their limbs. Began to hallucinate they could fly. Did strange things to their dogs with forks. Other weird behaviors.

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17
Q

Paralytic Shellfish Poisoning

A

Results from eating oysters, clams, or scallops contaminated with saxitoxin.
-Nerve poison produced by algae.
Symptoms,
Numbness in mouth & extremities.
Gastroenteritis
Difficulty speaking and walking.
Death in small percentage of cases.

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18
Q

Foodborne Bacterial Diseases

A

Global public health problem.
Reported cases, 33 million/year.
9,000 deaths/year.

Microbial contaminants enter food via;
Water, milk, juice, cutting boards, meat products, cracked eggs, and seafood.

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19
Q

Who is at risk for foodborne bacterial diseases?

A

All at potential risk with high exposure.
Greatest risk & health consequences for those with weakened immune systems.

EX., HIV-AIDS patients. TB patients, cancer patients, pregnant women, infants, young children, and people over 65 years/old.

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20
Q

Way that Bacteria Cause Foodborne Illnesses;

A

(1) Ingestion of bacterial toxins present in food.
(2) By ingestion of pathogenic bacteria present in food or water.

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21
Q

(1) Bacterial Toxins in Food: Botulism

A

~Clostridium Botulinum
*Anerobic bacteria
Life-threatening, systemic paralyses.
Ingestions of preformed bacterial toxin results in paralysis of cranial & peripheral nerves.
Neurological symptoms.
Incubation usually 12-36 or more hours.

*SHORTER incubation = MORE SEVERE ILLNESSES.

Low case fatality rate (<15%) during past decrease when treatment adequate.
High fatality rate w/o treatment, 1/3rd die within 3-7days.
Slow recovery, can take months of years.

22
Q

Botulism : Symptoms

A

-Dizziness
-Dry mouth
-Difficulty swallowing
-Drooping eyelids
-Double vision
-Slurred speech
-Nausea, vomiting, diarrhea may occur
-Weak muscles
-Descending paralysis
-Death usually from respiratory paralysis **

23
Q

Botulism Transmission: Common Sources in the U.S. & Overseas:

A

Tuna fish, chicken, luncheon meats, green beans, soups, beets, mushrooms, asparagus ripe olives, spinach. Europe; smoked or preserved meat. Japan; smoked or preserved fish.

Wound botulism is rare.
Honey or corn syrup (infant botulism).
commercially canned foods, meats & fish.
Home-canned fruit & vegetables.

24
Q

Bacterial Infections

A

Large number of live organisms ingested.
Onset of symptoms; 1 - 24hours after eating contaminated foods or liquids.

Similar symptoms:
-Diarrhea
-Abdominal pain
-Vomiting
-Dehydration
-Fevers
-Chills
EX. Salmonellosis

25
Q

Escherichia Coli. 0157:H7

A

E.coli is an normal inhabitant of the intestines.

Usually suppresses the growth of harmful bacteria in the body.

*E.coli 0157:H7 causes “hemorrhagic colitis”

~More deadly strain appeared in 1982.
~Children <5 years are more likely to develop hemolytic uremic syndrome (HUS).

26
Q

E.coli 0157:H7: Transmission

A

-Passed person-to-person (through feces)
-Contaminated foods
-Contaminated liquids or water
-Alfalfa sprouts
-Unpasteurized fruit juices
-Cheese curd
-Raw milk
-Undercooked or raw hamburgers

26
Q

E.coli 0157:H7: Symptoms

A

-Mean incubation period is 3-8 days; median 3-4 days.
-Severe cramping
-Watery & bloody diarrhea
-Low grade or no fever
-Occasional vomiting

27
Q

Salmonellosis: Transmission

A

-Ingestion of food from infected animals.
-Fecal contamination of stored food by rats & other infected animals.
-Turtles, banned as pets in the U.S.

27
Q

Common Food Sources of Salmonellosis:

A

-Raw meats
-Poultry
-Eggs
-Milk
-Dairy products
-Fish, shrimp, other seafoods
-Peanut butter

28
Q

Salmonellosis

A

*2nd most common cause of foodborne illness
~Responsible for a million cases of foodborne illness a year.
US cause is by Salmonella Enteritidis.
-Infection ranges from carrier state to potentially fatal conditions.
-Gastroenteritis: most common clinical manifestation.
Worldwide, >1,800 strains
USA: 10 common strains
~Usually caused by Salmonella enteritidis
~Infection rate is highest in babies and young children.

29
Q

Salmonellosis Symptoms

A

-Incubation period is usually 12-36 hours
-Communicable, several days to several weeks.

-Nausea
-Vomiting
Abdominal cramps
-Diarrhea
-Fever
-Chills
-Headache

30
Q

Shigellosis

A

~Worldwide: 164.7 million
-caused by Shigella
-highly infective
-low inoculum required for Shigella infection (few as 10-200 b)

31
Q

Shigellosis is the 3rd most common cause of bacterial gastroenteritis in the U.S.
TRUE or FALSE

A

TRUE

~Shigellosis is the 3rd most common cause of bacterial gastroenteritis in the U.S.
**15,000 cases/year in the U.S.

32
Q

Shigellosis:

A

Most common in children ages 6 months to 5 years.
-Gastroenteritis is the most common clinical manifestation.

Transmission:
S. is spread by fecal-oral contact; via infected food or water.

-During travel
-In long-term care facilities.
-Day care centers
-Nursing homes
-Direct contact with infected persons.
-Swimming in contaminated water.

33
Q

Continuation of Shigellosis, SYMPTOMS

A

-Appear 1 - 7 days after exposure
-Lower abdominal tenderness
-Increased bowl sounds
-Dehydration, fever
-Bloody diarrhea, tenesmus
-Passage of mucus
-Self-limited course: symptoms last for 3 days to 1 week & rarely lasts as long as 3 weeks.
-Hemolytic uremic syndrome (HUS) may complicate this infection.
(characterized by hemolysis, renal failure, uremia, & disseminated intravascular coagulation.
-Mortality rate: >50%

34
Q

Shigellosis in Adult Males

A

-Recent report indicated an increase of S. flexneri serotype, 3 infections among adult males in the U.S.
-Potential for sexual transmission of enteric infections among men who have sex with men in major cities US, Europe, & Australia.
(Among risk factors for sexual transmission of Shigella likely involve exposure to fecal materials).
-Outbreaks among MSM, 50-90% of patients reported oral-genital or oral-anal contact.

35
Q

Viral Infections: Norovirus

A

-Transmitted easily within closed environments such as cruise ships.
-May be brought on board by passengers who fall ill just before embarking on a cruise.
-Crew members & ship-board environmental contamination may act as disease reservoirs.

36
Q

Norovirus Symptoms

A

-Vomiting
-Diarrhea
-Dehydration
-Abdominal cramps
{Symptoms last from one to two days}

37
Q

Foodborne Parasitical Diseases: Helminths-Trichinellosis (trichinosis)

A

Caused by Trinchinella Spiralis
-Humans infected with this parasite when they eat undercooked mean (pork) infested by infective T.s. larvae (juveniles).
-Widely distributed in Europe & U.S.
-Originated in the northern hemisphere, but now is present in South America, Africa.
-Present in New Zealand, but in Australia.

38
Q

Clinical symptoms of Helminths-Trichinellosis

A

Incubation period ~1-6 weeks.
-Bilateral periorbital edema
-Conjunctivitis
-Fiver
-Muscle pain
-Diarrhea
-Vomiting
-Pneumonia
-Nervous disorders

39
Q

Cysticercosis

A

-Caused after ingesting eggs from a tapeworm, Taenia Solium (fecal-oral transmission)
-In the intestinal tract, ingested eggs (T.solium) became embryonic eggs, which are able to cross the intestinal wall, reaching blood flow.
-They reach any organ, where they become cysticerci, which results in a condition known as cysticerosis.
-When cysts are found in the brain, the clinical form is called neurocysticercosis.

40
Q

LIFE CYCLE SLIDE 40

A
41
Q

Epidemiology of Cysticersosis

A

***Cysticercosis is a worldwide infection.
-Common in developing countries & eating pork.
-Fruits & vegetables contaminated with eggs of T.solium.
-Can be spread by contact with infected people or fecal matter.
**Rare in the US

42
Q

Clinical symptoms of Cysticercosis

A

Clinical symptoms of cysticercosis depends on which organs are infected & number of cysticercosis.
-Ocular cysticercosis
-Muscular cysticercosis
-Neurocysticercosis could lead to traumatic neurological damage: headaches, confusion, lack of attention, difficulty with balance, swelling of the brain, death (when the infection is heavy).

43
Q

Prions

A

Prions are regarded as the bovine spongiform encephalopathy (BSE), a neurological disease in cattle.
-The course of BSE is progressive, ultimately fatal, & is potentially transmissible among cattle.
-An extensive outbreak among cattle occurred in the United Kingdom beginning in 1986.
-Reported in 20 European countries as well as Japan, Israel, & Canada.
-Cases have been reported in the U.S. (2003 & later.
-Appears to be spreading among cattle by feeds that contain rendered cattle products.

44
Q

Variant Creutzfeldt-Jakob Disease (vCJD)

A

-Form of Prions disease in humans.
-“has been linked causally to bovine spongiform encephalopathy, with human cases thought due to dietary exposure to BSE-contaminated tissues.

45
Q

Foodborne Diseases: Chemical Hazards

A

1) Pesticide residues: DDD, Dioxins, malathion.

2) Food additives: Cyclamate, carcinogens [safrole, mutagen * carcinogen, coal-tar dyes, carcinogen or organ damage].

3) Lead: heavy metal toxic at low doses, causes anemia & damage to nervous system. Ceramic jars from Mexico, paint contains lead & candy packaged in paper marked with lead containing paints.

4) Mercury:
Tuna fish, swordfish or shark only if eaten frequently; variety of seafood is important.

46
Q

Sources of Metal Poisoning

A

-Metals that have leached into foods (especially acidic foods) from metal containers & cooking vessels.
-Candy wrappers from Mexico made with lead.
-Chicken may contain high levels of arsenic, which is used as an approved food supplement for chickens to control intestinal parasites.
-Certain species of fish–shark, swordfish, king mackerel, & tilefish–have levels of mercury that may be high enough to be harmful with developing human fetuses.

47
Q

Pesticides in Foods

A

-Applied to crops to reduce the impact of insects & other hazards.
-They may leave residues that remain on food crops.
-Dietary sources are one of the principal means of exposure of the population to persistent, organic chemicals, which include the family of:
Organochlorine pesticides & polychlorinated biphenyls.

48
Q

Antimicrobials in Meat

A

-Similar or identical to those used by humans.
-For disease prevention & growth enhancement among animals (cattle, swine, poultry, & fish).
-US-approved antimicrobials to use with food animals:
~Amoxicillin
~Penicillin
~Bacitracin
~Erythromycin

49
Q

The use of Antimicrobials as a Potential Problem:

A

-Residues of antimicrobial agents may persist in meat that is destined for human consumption.
-Possible indirect toxicity, which causes loss of effective therapeutic interventions (e.g., through microorganisms that are resistant to antimicrobial drugs).

50
Q
A