for final Flashcards

(37 cards)

1
Q

main parts of the central nervous system

A

the brain and spinal cord

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2
Q

role of the central nervous system

A

integrates/coordinates input and output; thoughts, emotions, memories

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3
Q

2 parts to the peripheral nervous system

A

sensory input and motor output

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4
Q

sensory input

A

input from sensory receptors responding to external stimuli, skin muscles and joints, internal organs

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5
Q

2 parts of motor output

A

somatic and autonomic nervous system

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6
Q

somatic nervous system

A

directs voluntary movement

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7
Q

autonomic nervous system

A

regulates involuntary bodily activities (heart rate and breathing)

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8
Q

autonomic nervous system branches off to:

A

parasympathetic nervous system and sympathetic nervous system

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9
Q

Parasympathetic nervous system

A

governs bodily activities during restful conditions (acetylcholine)

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10
Q

Sympathetic nervous system

A

prepares body for stressful or emergency situations (norepinephrine)

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11
Q

major cell types of the adult human CNS

A
  1. neurons
  2. Oligodendrocytes (CNS) and Schwann cells (PNS)
  3. Astrocytes
  4. Microglia
  5. Ependymal cells
    ** 2-5 can be classified together as “glial” cells**
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12
Q

Most abundant cell type in the adult human CNS?

A

Astrocytes

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13
Q

why are pain fibres not the fastest? (neurone)

A

because they do not have a reflex arc

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14
Q

reflex arc

A

the basic unit of a reflex, which involves neural pathways acting on an impulse before that impulse has reached the brain

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15
Q

What is the term(s) for a neurotransmitter specific to a given pre-synaptic neuron?

A

neurotransmitter

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16
Q

Insufficient levels of dopamine, serotonin and norepinephrine are associated with

17
Q

Lack of acetylcholine is associated with

A

Alzhiemer’s

18
Q

Steps of a neurotransmitter

A

Step 1: impulse reaches the axon ending of the presynaptic membrane
Step 2: Synaptic vesicles release neurotransmitter into the synaptic cleft

19
Q

OLIGODENDROCYTES

A
  • produce myelin
  • span multiple axons (each cell can support up to 30 myelin rolls)
  • are found in the CNS
20
Q

SCHWANN CELLS (PNS)

A
  • produce myelin
  • do not span multiple axons
  • are found in the PNS
21
Q

Astrocytes:

A

stellate (star-like) morphology
- Very important for communication
- More abundant than neurons

22
Q

Microglia:

A

mobile macrophage-like immune cells

23
Q

Ependymal cells:

A

line the ventricles to form a barrier; produces cerebrospinal fluid

24
Q

what gets through the blood brain barrier?

A
  • Mostly very small lipid soluble compounds (essential fatty acids)
  • Caffeine/alcohol
    = A problem when targeting drugs for the brain
25
how does glucose get through the blood brain barrier?
A specific glucose transporter (GLUT1 – not insulin sensitive)
26
Positron emission tomography (PET):
tracks glucose uptake (glucose tracer)
27
Functional magnetic resonance imaging (fMRI):
tracks blood flow – deoxyhemoglobin is paramagneticoIt
28
Networks are identified by
neurons using the same neurotransmitter
29
Norepinephrine network modulates:
attention, arousal, sleep-wake, learning, memory, pain, anxiety and mood
30
Psychostimulants:
methamphetamine, Ritalin (used by some college/university students as “smart drugs”), caffeine
31
Serotonin network (affected with mood modulates):
pain, sleep-wake cycle, emotion
32
Acetylcholine network modulates:
arousal, sleep-wake, learning, memory, sensory informationo
33
Alzheimer’s disease characterized in part by:
- Massive loss in cholinergic neurons (nerves that release acetylcholine) - Low acetylcholine levelsoV
34
Various drugs available in Canada to treat Alzheimer’s symptoms are
cholinesterase (enzyme that rapidly breaks down Ach in the synapse) inhibitors Controls the signal being continuously released (blocks the inhibitor so you are not breaking it down as fast)
35
Dopamine network modulates:
motor control, reward/pleasure centers
36
Dopamine agonists (stimulates; acts too similarly and mimics) used to increase health-span of individuals with:
Parkinson’s disease
37