formative 1

Question 1

function of fibroblasts

Answer 1

collagen synthesis

Question 2

highly metabolically active small cuboidal cells, which layer

Answer 2

basal layer

Question 3

layer assoc with odland bodies

Answer 3

granular

Question 4

layer assoc with polyhedral cells with lots of desmosomes

Answer 4

prickle cell layer

Question 5

layer assoc with corneocytes

Answer 5

keratin layer

Question 6

direct cell killing hyersensitivity reaction

Answer 6

type II

Question 7

immune complex mediated hypersensitivity reaction

Answer 7

type III

Question 8

which layer is most metabolically active

Answer 8

basal

Question 9

embryolocial migration of melanocytes

Answer 9

melanocytes migrate to skin from neural crest

Question 10

langerhan cells

Answer 10

migrate through epidermis and dermus + travel via lymphatic to present antigens to lymph nodes

they are formed in bone marrow

Question 11

systems important in maintaining good circulation in the lower limb

Answer 11

muscle pump
venous valves
pulse pressure

Question 12

what carries out vit D metabolism

Answer 12

keratinocytes

Question 13

responsible for epidermal proliferation

Answer 13

basal cells

Question 14

tensile strength

Answer 14

collagen

Question 15

what percentage of GP consultations are skin problems

Answer 15

15-23%

Question 16

fibroblasts, lymphatics and ground substance are present in what layer of the skin

Answer 16

dermis

Question 17

where are hemi desmosomes found

Answer 17

epidermal junction

Question 18

MoA of impedin virulence factor? modulin?

Answer 18

enables the organism to avoid host defense mechanisms

modulin = causes damage to host INdirectly

Question 19

how long does it take for cells to migrate from the basal layer to the keratin layer

Answer 19

28days

Question 20

when do cells lose their nuclei

Answer 20

granular, is complete by keratin layer

Question 21

how many cells thick in the granular layer

Answer 21

2-3

Question 22

developmental growth pattern of skin follows what

Answer 22

blaschkos lines

Question 23

lunula of nail

Answer 23

white bit proximal part of nail under skin

Question 24

component of MRSA strain which causes necrotising fasciitis

Answer 24

panton valentine leukocidin

Question 25

nails

Answer 25

hard densely packed keratin similar to hair finger nails grow at 0.1mm a day toe nails grow slower commonly affected by disease

Question 26

deficient enzyme in acute intermittent porphyria

Answer 26

PBG deaminase | porphobilinogen deaminase

Question 27

commonest sweat gland on face

Answer 27

eccrine glands

Question 28

which sweat glands play a role in temp regulation

Answer 28

eccrine moisten palms/soles for grip

Question 29

which sweat glands are involved in scent

Answer 29

apocrine - P for pits

Question 30

Meissners corpuscles

Answer 30

vibration sensation

Question 31

pacinian corpuscles

Answer 31

Pressure sensation

Question 32

involuting phase of hair grow

Answer 32

catagen

Question 33

stages of hair growth

Answer 33

anagen -> catagen -> telogen growing -> involuting - > resting

Question 34

deficient enzyme in erythropoeitic protoporphyria

Answer 34

ferrochelatase build up of protoporphyrin IV

Question 35

where are sebaceous glands not found

Answer 35

palms, soles and dorsum sebaceous = holocrine

Question 36

which of apocrine and eccrine are apart of the pilosebaceous unit

Answer 36

apocrine = part of pilosebaceous unit eccrine not

Question 37

what controls eccrine glands

Answer 37

sympathetic nervous system regulate body temo by secretinng salty solution highest conc on palms + soles

Question 38

main fibres of dermis? what binds them?

Answer 38

collagen + elastin bound together by ground substance

Question 39

where are merkel cells found, function?

Answer 39

basal layer slow adapting mechanoreceptors which are important in ligth touch sensation

Question 40

langerhans cells

Answer 40

antigen presenting cel whihc belongs to fam of dendritic cells presents antigens to naive T cells present in the regional lymph nodes in order to iniate adaptive immune response

Question 41

in what part of the body is there an extra layer of the epidermis

Answer 41

palms + soles stratum lucidum - located between keratin + granular layer