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Tricky facts > fresh Q updates still unsure > Flashcards

fresh Q updates still unsure Flashcards

1
Q

affected by acetylator slow fast status

A

nitrazepam

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2
Q

MAOI can cause dependence

A

trancylopramine

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3
Q

prolong QTC normal doses

A

trazadone

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4
Q

anti dementia drug no hepatic involvement

A

rivastigmine

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5
Q

phenelzine useful for

A

social phobia

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6
Q

efficacy antiPs determined by nigrostriatal binding etc - true or false

A

false

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7
Q

steady state concentration of drug is doubled by what

A

doubling admin rate

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8
Q

MAOIS short or fast Half life

A

short

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9
Q

more than 2 copies CYP gene

A

ultra rapid metaboliser

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10
Q

trancyclopromine to paroxetine

A

wait 2 weeks

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11
Q

HIV cells least likely affected

A

neurones

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12
Q

cerebral torque disturbance

A

psychosis

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13
Q

increased what at axon prior to depolarisation

A

potassium

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14
Q

increased or decreased glutamate in Alzheimers

A

increased

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15
Q

cleft palate in preg

A

SSRI and lamotrigine

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16
Q

does hypertension happen with SSRIs

A

no

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17
Q

clozapine seizure risk increased by

A

0.1

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18
Q

Flumazenil competitive or non

A

competitive

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19
Q

more potent inhibitor paroxetine or sertraline

A

paroxetine

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20
Q

phencylicidine acts on which receptor mimic schizophrenia symptoms

A

NMDA

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21
Q

d2 inhibitory or excitatory

A

inhibitory

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22
Q

5HT auto regulatory function

A

5HT1b

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23
Q

how does methylphenidate work

A

NDRI

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24
Q

highly selective dopamine antagonist

A

amisulpride/sulpride

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25
Q

PTSD eye movements REm

A

increased

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26
Q

delirium tremens EEG

A

low voltage fast activity

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27
Q

fluoxetine to duloxetine switch

A

stop and start other immediately

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28
Q

trazodone to mirtaz

A

cross taper

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29
Q

amitryptiline to SSRI

A

half dose start new then withdrawal

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30
Q

agranuloctysos risk

A

older and female, asian/jewish

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31
Q

neutropenia risk

A

young black low baseline WCC

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32
Q

weight gain antiPs more significant in

A

children

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33
Q

non ionising, look at blood flow/oxygen metabolism

A

f-MRI

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34
Q

is COMT involved in serotonin

A

no

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35
Q

vortioxetine action is on

A

5HT3

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36
Q

agranulocytosis risk after 1 year

A

0.01%

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37
Q

less likely manic switch

A

sertraline

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38
Q

disulfiram side effect

A

headache

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39
Q

carbamazepine can raised level of

A

phenytoin

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40
Q

slow rhythmic disorder affects extremiteies

A

athetosis

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41
Q

alpha 2 agonist with less hypotension

A

lofexidine

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42
Q

sibutramine for weight loss can cause what

A

serotonin syndrome, collapse

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43
Q

zopiclone acts on what exactly

A

alpha 1 subunit of omega 1

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44
Q

counteract effect opioids and help stop use

A

naltrexone

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45
Q

depot longest half life

A

palperidone

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46
Q

best antiP if low sodium

A

clozapine

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47
Q

modafinil acts on which neurotransmitter

A

dopamine

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48
Q

which ion flows into neurons to propagate action potentials

A

sodium

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49
Q

commonly raised hormone in depression

A

CRH

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50
Q

12-16hz sleep

A

sleep spindles stage 2

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51
Q

stroop test for

A

selective attention, inhibitory control

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52
Q

most abundant fast excitatory

A

glutamate

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53
Q

d amphetamine schizophrenia test affects what area brain

A

striatum

54
Q

initial release dopamine alcohol addiction

A

Ventral tegmental area

55
Q

how to benefit PTSD sleep disturbance

A

reduce REM latency

56
Q

decreased volume of what in autism

A

corpus callosum

57
Q

neurotransmitter shuttles through astrocytes

A

glutamate

58
Q

testing to confirm Williams

A

FISH

59
Q

endoscope function

A

degradation of lipids

60
Q

epigenetic mechanism most associated with schizophrenia

A

DNA methylation

61
Q

frontal lobe proprotion

A

37-41%

62
Q

what most commonly uses glutamate as transmitter

A

granular and pyramidal cells

63
Q

cell type conveying motor signals

A

pyramidal

64
Q

trazodone to mirtazepine

A

cross taper with caution

65
Q

wolf P White ass with lithium?

A

no

66
Q

bentos work as

A

allosteric modulator

67
Q

carbidopa works how

A

inhibits DOPA decarboxylase

68
Q

SSRIs increase bleeding risk how

A

inhibit transport responseible for uptake serotonin into platelets

69
Q

which 2 mood stablisers together increase serum concs

A

lamotrigine and valproate

70
Q

attention and task switching skills?

A

trail making test

71
Q

hallmark memory deficit korsakoffs

A

anterograde

72
Q

difficulty coordinating movements right arm

A

corticobasal degeneration

73
Q

pure maternal inheritence

A

Leber’s

74
Q

T/F: most rare copy number mutations are unique schizophrenia

A

false

75
Q

is there strong or weak link between alcohol dep. and copy number variations Cr5

A

strong link

76
Q

unilateral anosmia

A

frontal lobe sign

77
Q

bulbar palsy

A

wasting tongue

78
Q

west syndrome EEG

A

hypsarrythmia

79
Q

brain region which limits empathetic expression?

A

supra marginal gyrus

80
Q

IG what to be tested in anti NMDA encephlaitis

A

IGG

81
Q

5HT1 is what coupled

A

G coupled

82
Q

5HiAA in aggressive impulsive and also in suicidal patients

A

low

83
Q

PTSD sleep disturbance would show

A

greater REM density

84
Q

enzyme pair precursor to amyloid products in Alzheimers

A

gamma and beta

85
Q

reward pathway

A

mesolimbic

86
Q

primary dopamine pathway

A

L-phenyla to L tyrosine to L dopa to dopamine

87
Q

increased D2 in basal ganglia in what

A

parkinsons

88
Q

night terrors what stage

A

mostly 4 also 3 to 4 transition

89
Q

least likely nuclei to degenerate in old age

A

Inferior

90
Q

secondary messenger CNS

A

calcium

91
Q

enzyme preclude amyloid formation

A

alpha

92
Q

part of brain most assoc with prior disease

A

cerebellum

93
Q

tremor Hz in PD

A

4-6Hz

94
Q

tau effect microtubules

A

stablises

95
Q

part brain affected cocaine

A

nucleus accumbens

96
Q

main rate limiting step alcohol

A

alcohol dehygrogenase

97
Q

target where in TMS depression

A

left frontal

98
Q

best technique for tract specific lesion

A

DTI

99
Q

earliest histological change in Alz

A

amyloid

100
Q

recent focus genetic research ass with intellectual deficits

A

copy number variations

101
Q

insulin like growth factor secreted from?

A

liver

102
Q

EEGs for seizures, specific or sensitive

A

specific

103
Q

subcortical or periventricular opacities more likely in old person with depression

A

subcortical

104
Q

area not involved in wakefulness

A

cerebellum

105
Q

is glycation epigenetic

A

no

106
Q

semanticc dementia, difficulty naming, area affected?

A

ant tempiral

107
Q

anomia area affected

A

arcuate fasciculus

108
Q

most abundant dopamine in brain

A

D1

109
Q

measures extent myelination

A

DTI

110
Q

hypoperfusion.metabolism where in LBD

A

occipital parietal region

111
Q

sulphide first pass effect?

A

low

112
Q

at high dose duloxetine also does what

A

inhibits dopamine

113
Q

donepezil metabolised by

A

2D6 and 3A4

114
Q

stopped suddenly v likely to have withdrawals

A

venlafaxine

115
Q

benzos decrease or increase neuronal excitability

A

decrease

116
Q

melatonin also binds to

A

5ht2c

117
Q

is desipramine a prodrug

A

no a metabolite

118
Q

how many stages before general use

A

5

119
Q

sertraline active metabolite

A

N desmethyl sertraline

120
Q

food effect on lurasidone

A

increases absorption

121
Q

is pregabalin metabolised

A

no excreted without

122
Q

high rate behavioural side effects

A

leviteracetam

123
Q

sertraline percet protein bound

A

98

124
Q

target OCD in brain stimulation

A

STN
internal capsule

125
Q

bipolar animal models

A

circadian rhythm disturbance
BNDF mice

126
Q

anterior insula in addiction

A

affected yes - craving

127
Q

suicidality neuro changes

A

tryptophan polymorph
cytokine excess
microglia activation

128
Q

venlafaxine half life

A

3-7 hours, approx 5

129
Q

schizophrenigenic mother

A

From reichman

130
Q

biopsychosocial model proposed by

A

George engel

Tricky facts (8 decks)

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