From samplexes

Question 1

Two NSAIDS noted to decrease incidence of colon cancer

Answer 1

Aspirin and Celecoxib

Question 2

Priopionic acid derivative NSAID that is “MILDLY URICOSURIC”

Answer 2

Oxaprozin

Question 3

Inhibits cox3 enzyme in the CNS

Answer 3

Acetaminophen

Question 4

Methotrexate induced _____ and ____ disorders

This vitamin is given to prevent these risks

Answer 4

GI and liver, follic acid is given

Question 5

Methotrexate, _______________ drug creates these AEs that’s why it’s important to give the patient follic acid

Answer 5

GI and Liver abnormalities

Methotrexate is a DMARDS

Question 6

First non-purine inhibitor of xanthine oxidase

Answer 6

Febuxostat

Question 7

Non acid ketone prodrug NSAID

Answer 7

Nabumetone

Question 8

Only NSAID with a single enantiomer

Answer 8

Naproxen

Question 9

This drug inhibits not only COX but also LOX enzyme

Answer 9

Ketoprofen

Question 10

What DMARD can cause ototoxicity at doses greater than 250 mg/day

Answer 10

Chloroquine

Question 11

What DMARD can cause ototoxicity at doses greater than 6.4 mg/kg/day

Answer 11

Hydroxychloroquine

Question 12

Antigout that prevent polymerization of microtubules > prevent leukocyte migration

Answer 12

Colchicine

Question 13

Symptoms seen in a patient that takes 5 grams of ASA

Answer 13

salicylism: Tinnitus, Malaise, deafness, dizziness

Question 14

NSAIDS associated with GOUT

Tolmetin and Oxaprozin

Answer 14

Tolmetin - not efficient

Oxaprozin -long half life, propionic acid derivative mildly uricosuric

Question 15

Mechanism of uricosuric agents in gout

Answer 15

Decrease pool of uric acid by enhanced uric acid secretion

Question 16

NSAIDS that irreversibly acetylates cox in PLATELETS

Answer 16

Asa

Question 17

NSAIDs effective in closing Patent Ductus Arteriosis

Answer 17

Ibuprofen

Indomethacin

Question 18

Methotrexate’s bioavailability increase when taken with

Answer 18

Grapefruit juice