frontotemporal lobar degeneration

Question 1

what are the different types of frontotemporal lobar degeneration?

Answer 1

Frontotemporal dementia (Pick’s disease)

Progressive non fluent aphasia (chronic progressive aphasia, CPA)

Semantic dementia

Question 2

what are common features of frontotemporal lobar dementia?

Answer 2

onset before 65
insidious onset
relatively preserved memory + visuospatial skills
personality change + social conduct problems

Question 3

what is pick’s disease?

Answer 3

most common type
characterised by personality change + impaired social conduct

Question 4

what are features of pick’s disease?

Answer 4

personality change
impaired social conduct
hyperorality
disinhibition
increased appetite
perseveration behaviours

Question 5

what are MRI/CT findings of Pick’s disease?

Answer 5

atrophy of frontal + temporal lobes

focal gyral atrophy with a knife-blade appearance

Question 6

what are features of chronic progressive aphasia CPA?

Answer 6

non fluent speech
short utterances that are agrammatic
comprehension is relatively preserved

Question 7

what are features of semantic dementia?

Answer 7

fluent progressive aphasia
fluent speech but empty + conveys little meaning
short-term memory better