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Drugs > FTM 1 Exam 1 Drugs > Flashcards

FTM 1 Exam 1 Drugs Flashcards

1
Q

What prevents microtubule disassembly and what category of drug is it?

A

Taxol

-anti-cancer

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2
Q

What Prevents microtubule assembly (polymerization) fights inflammation and what category of drug is it?

A

Colchicine

-anti-gout, anti-cancer

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3
Q

What presents microtubule assembly and what category of drug is it?

A

Vincristine/vinblastine

-anti-cancer

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4
Q

What disrupts actin function–> no cell movement and what category of drug is it?

A

Phalloidin and Cytochalasin

-Toxin

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5
Q

What inhibits DNA gyrase and What disrupts actin function–> no cell movement and what category of drug is it?

A

Ciproflaxin (antibiotic respiratory infection)
Novabiocin (antibiotic staph infection, MRSA)
Nalidixic Acid (Antibiotic respiratory infection and UTI)

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6
Q

What disrupts DNA elongation —> base lacks 3’ OH and what category of drug is it?

A 
Azidothymidine (AZT) Zidovudine
-anti-viral
Didanosine (ddl)
-anti-viral
Acylovir
-anti-viral (herpes)
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7
Q

What disrupts DNA elongation –> competes w/ dATP and what category of drug is it?

A

Tenofovir

-anti-viral

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8
Q

What has 3’ OH = stereo restraint —> chain termination and what category of drug is it?

A

Adenine Arabinoside (araA)
-anti-viral
Cytosine arabinoside (araC)
-anti-cancer

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9
Q

What binds and inhibits topoisomerase I and what category of drug is it?

A

Camptothecin

-anti-cancer

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10
Q

What inhibits topoisomerase II and what category of drug is it?

A

Etoposide

-anti-cancer

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11
Q

What inhibits RNA polymerization on both prokaryotes and eukaryotes and what category of drug is it?

A

Actinomycin D

-anti-cancer

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12
Q

What inhibits RNA polymerase –> inhibit initiation of transcription and what category of drug is it?

A

Rifampin

-antibiotic

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13
Q

What inhibits RNA polymerase II —> hepatotoxicity–> death and what category of drug is it?

A

alpha-amanitin (mushroom)

-toxin

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14
Q

What inhibits RNA polymerase II –> not absorbed by the GI tract –> not toxic by oral intake and what category of drug is it?

A

Phalloidin

-toxin

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15
Q

What blocks initiation and prevents assembly of ribosomes by binding to 30s and what category of drug is it?

A

Streptomycin

-abx

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16
Q

What blocks elongation and prevents aminoacyl-tRNA access to A site and what category of drug is it?

A

Tetracycline

-abx

17
Q

What blocks elongation and blocks ribosomes translocation by binding to 50s and what category of drug is it?

A

Erythromycin

-abx

18
Q

What blocks elongation and prevents peptidyl transferase activity in prokaryotes and what category of drug is it?

A

Chloramphenicol

-abx

19
Q

What blocks elongation and prevents peptidyl transferase activity in eukaryotes and what category of drug is it?

A

Cycloheximide
-abx
(not really used in humans)

20
Q

What blocks elongation and premature termination in translation by bearing structural resemblance to aminoacyl-tRNA and what category of drug is it?

A

Puromycin
-abx
(not really used in humans)

21
Q

What inactivated EF-2 –> prevent translocation and what category of drug is it?

A

Diphtheria toxin

-toxin

22
Q

What inhibits conversion of IMP to GMP and what category of drug is it?

A

Mycophenolic acid

-immunosuppressive

23
Q

What inhibits folate synthesis and what category of drug is it?

A

sulfonamide/sulfa drugs

-abx

24
Q

What inhibits bacterial dihydrofolate and what category of drug is it?

A

Trimethoprim

-abx

25
Q

What inhibits eukaryotic dihydrofolate reductase and what category of drug is it?

A

Methotrexate

-anti-cancer

26
Q

What inhibits ribonucleotide reductase and what category of drug is it?

A

hydroxyurea

-anti-cancer

27
Q

What inhibits xanthine oxidase and what category of drug is it?

A

allopurinol

-anti-gout

28
Q

What inhibits thidiylate synthase and what category of drug is it?

A

5’ Fluorouracil

-anti-cancer

Drugs (1 decks)

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