Functional Anatomy Of Dementias

Question 0

Describe the neuroanatomical spread of damage in Alzheimer’s disease?

Answer 0

Starts at the transentorhial region spreads to the hippocampus, then spread to lateral and posterior parts temporal and parietal neocortex. Eventually more widespread damage.

Question 1

What neurotransmitters modulate behaviour and mood vs memory and attention?

Answer 1

Dopaminergic, serotonergic and noradrenergic modulates behaviour and mood Cholinergic pathway modulated memory and attention

Question 3

What is distribution of neuropathology of vascular dementia?

Answer 3

A patchwork of cortical and subcortical damage or white matter tracts.

Question 4

name the structures in the picture below

Answer 4

Question 5

Name some corticostriatal pathways that produce specific effects on behaviour?

Answer 5

1. Dorsolateral prefrontal cortex connects with central band of the caudate - poor organisation, planning, decreased cognitive flexibility and working memory
2. Lateral orbital frontal cortex connects to the **ventromedial caudate - **impulsiveness, distractibility and disinhibition.
3. Anterior cingulate cortex connects to the nucleus accumbens - apathy, poverty of speech or akinetic mutism.