Functional plasticity Flashcards
(22 cards)
Difference between neurotransmission and neuromodulation
NT- membrane voltage &Ions
NM- Gene transcripton, channel gating properites, protein phsophorylation
What does neruomodulation use and examples
Neuropeptides like substance P, oxytocin, neruopeptide Y
What does neruomodulation in behaviour
They change the context of the network
Eating will change how we respond to stimuli comapred to hungry
How do we test neruomodulation
remove or add neuropeptide and receptor
Neuromodulators reconfigure nerual circuits to..
- mediate behvioural and nerual network states
- mediate learning
Neuromodulators reconfigure nerual circuits by
- Modulating neruonal responses
- Modualting synaptic transmission
Advantages of using c.elegans
only model to..
Only model where they have full connectivity map for both sexes
Advantage of having full connectivity map of c.elegans
They will know the exact marker, position and cell they are recording from
Hermaphordites
ICONS!
Carry their own sperm - DO NOT MATE
Self-fertilise
Males need to fuck the hemaphrodites
Aversive learning
Odour and punishment (no food) causes repulsion to odour
What combo trumps aversive learning and who is affected
sexual conditioning
Odour & no food & Mate = attraction
Only males affected
How is sexual reward incorporated into the circuit & how does it change odour processing to alter behavioural response
So how does it explain why sexual conditioning causes attraction
2 memoriesare formed which compete for expression
What is required for sexual conditioning
PDF-1 neruopeptide
What experiemnt did they do with pdf-1
Crelox deletion of pdf-1
What happens when you KO Pdf-1
stops sexual conditioning partially
Nerve ring
C.elegans brain
Where neural processing occurs
Which interneurons recieve pdf1for sexual conditioning
MCM and AVB interneurons
MCM only in male circuits
both pre-motor interneruons
Which neurons are active in sexual conditioning & what method was used
AVB is active, not MCM
Used CAMPARI and blue light stimuli
What is aversive learning regulated by
Pdf-1 or Pdf-2
How did they test which neruons recieve pdf-1 modulation
crelox on the pdf-1 recpetors of the neruons to find the neurons
RIA RIM AIY
what does neruomodulation provide to hair-wired circuits
fucntional plasiticty
due to neuropeptide levels and time acitivated
What underlies aversive leanring
PKG translocation to nucleus in sensory AWC neuron
