Fungal infections Flashcards

(30 cards)

1
Q

what are Mycoses?

what are primary fungal infections

what are oppoutunisitc fungal infections

A

mycoses= fungal ifnection, small number of the 100 pathogenic are clincially significant in healthy

Primary fungal infection- immunocompotent

oppourtunisitc fungal infections- immunocompromised

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2
Q

what are some common cutaneous fungal infections

A

athletes foot (tinea pedis)

general fungal infections of the skin (tinea corporis)

groin (tinea cruris)

nail infection (onychomycosis)

tinea verisoclor- interfere swith skin pigmentation

tinea cpaitis - fungal infection of the scalpe

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3
Q

Descibr tinea pedis

cuastive agent?

A
  • superificla skin infection caused by Tichiohyton rubrum (805)
  • working in hot, humid climates or working in high temperature enviornemtns and occulusive footwear most at risk
  • contratce nornally walking on syrface contaminated with infectious skin scales
  • 70% infected at some point in life
  • symptoms
    • scaly itchy or painful skin on the feet
      • between the toes (interdigigtal) or more widespread (moccasin)
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4
Q

what is this?

A

interdigital athletes foot

sclay ithcy painful skin on the feet

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5
Q

what is this?

A

moccasin widepsread athletes foot

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6
Q

what is the treatment for athletes foot

self care- good heygien, approptie fotowear

topical antifungal cream if mild not extensive ( terbinafine cream- or clotrimazole cream)

consider prescribing mildly potent topical corticosteriod if inflammed

oral Terbinafine if extensive

A
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7
Q

what is the causative agent of Tinea corporis

A

Trichopytom rubrum

or

trichophyton interdigital

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8
Q

tinea crusis is usally caused by…..

A

trichophyton rubrum, trichophyton interdigital

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9
Q

how are tinea corporis and tinea curis s(fungal infections of skin and gorin)m spread?

A

exposure to deswuamted skin flakes from infecte individuals (also zoonotic)

tinea cruiss is oftenc aused by scratching groin with finer nail containing infective material

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10
Q

risk factors of Tinea corprosi and tinea crusis

A

hot humid climates

working in high temrpature envuronemnt]guth fititng clothing

obesity

immuunocompromised states

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11
Q

symtpoms fo both tinea coprroris

A

hisotyr of itchy skin in the affected areas

single or mutlipemred or flat slightly raised ciruclar ring shape dpatches

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12
Q

what is this?

A

Tinea crusis

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13
Q

Treatment for Tiena crusis or Tinea corporis

A

topical fungal cream for non extnesive disease- terbinafine cream

consider prescri ign a mild potent topical corticosteriod if inflamamtion

consider prescribing oral terbinafine if extensive

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14
Q

what are symtoms of onychomycosis ( fungal nail)

A

the nauil looks abnormal, thickedn is dicosloured and briteel, generlaly invovles a singl nairl but others can be invovled?

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15
Q

What are the treamtnet options for Fungal nail (onychomycosis)

A

self care

keep short and filed down

antifungal only if uncomfrotable (cormobdiites, pyschological stress)

topcial anti-fungal if advised (generally amorofline 5%)

oral anti fungal if topical antifungals are unscusseful

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16
Q

what is Sporotirchosis

A

rare, subcutaneosu fungal infection

associated with handing decaying plant waste (rose handlers disease)

caustive agent (sporothrix schenckii)

  • symptoms
  • inital raised bump to from- progress and beocme larger to open sore or ulcertaed lesion that does not heal
  • satelite lesion may alos form
  • rarley pulmoanry disseminated disease
17
Q

What is the treatment for Sporotrichosis

A

oral antifungal for 6 months- Itraconazole

18
Q

what is mycetoma?

symptoms, cause, treatment?

A

subcutenaous skin infection fungal (cna be bacterial)

found in soil and water- most fungal ifnecitons caused by madurella grisea and Actinomadura madurae

  • symptoms
    • intially painless lesion—> abscess on foot—-> largher sore that leaks pus, blood erum, overtime destory undelying bone and muscle
  • treamtnet- as it is debillitating- surgical removal
19
Q

what is this?

A
  • Chromomycosis
    • caused mainly by Fronsecae Pedroso
    • most commonly found in tropical areas
    • begins as small painless lymp that professes ovterime to form srusty/sclart abscess
  • treatment
    • surgical removal/ long term anti fungal
20
Q

what are systemic fungal infections which may infected immunocompetent hosts?

A

Coccidiodymocosis (flu like sympotms- 10% long term lung,1% disseminate to skin/CNS/bone- symptoms nromamly resolve- endecmi to south america)

Histoplasmosis-(prevakent in south america, SE africa)-, associated with soils with high levesl of bat and bird droppings- immocompeten contained in lungs mild self limiting similar to Coccidiodes)- cna cause sevre dissemeninated in immunocmpromised

blastomycosis- common USA and canada

21
Q

what groups are susceptible to oppourtunisitc fungal infections

A

Those undergoing cancer treatment

Solid organ transplant recipients

Those receiving stem cell therapy

Neonates (pre-term)

Those with immunodeficiencies or who are immunocompromised

Intensive care patients

Complex surgical cases

In patients living with HIV

22
Q

Tinea pedis topic and oral treamtnets

A
  • topic
    • Terbinafine 1% cream for 7 days
    • clotrimaoole !% for 4 weeks
    • Miconazole 2% cream 2-6 weeks
  • oral
    • terbinafine
    • itraconzaole
23
Q

tu=inea crusis and tine coprois treatments oral and topica

A

Topical treatments

Terbinafine 1% cream for 7-14 dyas days

Clotrimazole 1% cream for 4 weeks

Miconazole 2% cream 10 days

Oral treatments

Terbinafine

Itraconazole

24
Q

Fungal nail infections treatment topical and oral?

A

Topical amorolfine paint

Oral treatments

Terbinafine

25
Candiaiass Treatment for vaginal
Intravaginal cream: Clotrimazole 10% Intravaginal pessaries: Clotrimazole 100mg Pessaries Oral tablets- Fluconazole
26
Oral candidiass treatment
Miconazole oral gel Nystatin suspension
27
mode of action fo Terbinafine
inhbti sfungal production of ergosterol---\> fiugnal cell membranes
28
mode of action of Azole antigunfals? Clotriazomole micaonzole ketoconazole ETC Flucanzole
inhbits cytohrome P450 depeendent enzymes invovled in the biosyntheiss of cell merbane sterols
29
How does nystain suppression for oral candiiasi work
bidns to ergosterol in fungal membrane formin pores- measn osmotic competence is lost
30
how does amorolfine (nail paint) worK
inhbits production of ergosterol!