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Antivirals SM > Fusion Inhibitors > Flashcards

Fusion Inhibitors Flashcards

1
Q

Enfuvirtide
MOA

A

Inhibits HIV entry into host cell.
Binds to HR1 subunit of gp41 inhibiting the conformational changes in gp41 required for the fusion of the virus with host cell

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2
Q

Enfuvirtide
Abs/Distrb/Elim

A

Given by subcut. injection.
Elimination t½ ~4h

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3
Q

Enfuvirtide
Clinical use

A

HIV-1 infection in combination with other antiretrovirals

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4
Q

Enfuvirtide
Adverse effects

A

Hypersensitivity reactions.

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Antivirals SM (7 decks)

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