G

Question 1

What is propranolol

Answer 1

a non- selective beta adrenoceptor blocker, useful antihypertensive agents by reducing cardiac output and vascular resistance

Question 2

What is verapamil

Answer 2

a calcium channel blocker that reduce blood pressure but do not cause bronchoconstriction

Question 3

T or F

For a drug to produce its biological effects it must bind to a receptor

Answer 3

true

Question 4

Most of the receptors are located on the cell surface or sometimes where?

Answer 4

nucleus/cytoplasm

Question 5

Examples of drug receptors that consist of proteins that would normally serve as receptors for endogenous regukatory ligands

Answer 5

Epi, NE, ACH

Question 6

T or F

All receptor are present in the cell membrane

Answer 6

False, not all

Question 7

Target of drug action:

atenolol-

Answer 7

receptor

Beta Receptor

Question 8

Target of drug action:

amlodipine-

Answer 8

Ion Channels

Calcium Channels

Question 9

Target of drug action:

ramipril-

Answer 9

Enzymes ACE

inhibits angiotensin Converting Enzyme

Question 10

Target of drug action:

Bendroflumethiazide (thiazides)-

Answer 10

Transporters (NaCl transporters

specifically block at the distal convoluted tubule

Question 11

Receptor State :

Inactive state->Active State

Answer 11

Agonist

Question 12

Receptor State :

Do NOT increases the fraction of the active state May Stabilize the receptor in the inactive state

Answer 12

Antagonist

Question 13

Receptor State :

Inactive State -> Active State but bot reaching 100 %

Answer 13

Partial Agonist

Question 14

T or F

In reversible equilibrium it favors more the inactive state

Answer 14

True beh

Question 15

Drug that bind to physiological receptors and mimic the regulatory effects of the endogenous signaling compound/ ligand

Answer 15

Agonist

Question 16

Drugs that would bind on the same recognition site as the endogenous ligand/ agonist

Answer 16

Primary agonist

Question 17

Agonist bind to the different region

Answer 17

Allosteric Agonist

Question 18

Transduction process that links drugs occupancy of receptors and Pharmacological response

Answer 18

Coupling

Question 19

T or F

In the absence of G protein the binding of the agonist to the receptor may only last for a few sconds

Answer 19

True

Question 20

T or F
In the presence of G protein, the binding of the agonist to the receptor may last longer therefore the duration of action is longer

Answer 20

True

Question 21

increases sensitivity to the agonist

Answer 21

spare receptors

Question 22

(+) spare receptors

EC50 is _____ kd

Answer 22

less than

Question 23

(-) spare receptors

EC50 is _____ kd

Answer 23

equal

Question 24

Phosphorylation or a similar chemical event that renders a receptor on the cell surface unresponsive too the ligand.

Answer 24

Taphylaxis