G Protein Messengers Flashcards Preview

*DIT/FA: Pharm > G Protein Messengers > Flashcards

Flashcards in G Protein Messengers Deck (14):
1

alpha 1

Gq protein class
Fxn:
- Increase vascular smooth mm contraction
- increase pupillary dilator mm contraction (mydriasis)
- intestinal and bladder sphincter contraction

2

alpha 2

Gi protein class
Fxn:
- decreased sympathetic outflow
- decreased insulin release
- decreased lipolysis
- increased platelet aggregation
- decreased aqueous humor production

3

Beta 1

Gs protein
Fxn:
- increased HR
- Increased contractility
- increased renin release
- increased lipolysis

4

Beta 2

Gs protein
Fxn:
- vasodilation
- bronchodilation
- increased lipolysis
- increased insulin release
- decreased uterine tone
- ciliary mm relaxation
- increased aq. humor production

5

Beta 3

Gs protein
Fxn:
increased lipolysis
increased thermogenesis in skeletal mm

6

M1

Gq
Fxn:
CNS, enteric nervous system parasympathetics

7

M2

Gi
Decreases HR and contractility of atria

8

M3

Gq
Fxn:
increased exocrine gland secretions
increased gut peristalsis
increased bladder contraction
bronchoconstriction
increased pupillary sphincter mm contraction (miosis)
ciliary mm contraction (accomodation)

9

D1

Gs
Fxn:
relaxes renal vascular smooth mm

10

D2

Gi
Fxn:
modulate transmitter release (esp. in brain)

11

H1

Gq protein
Fxn:
increased nasal and bronchial mucus production
increase vascular permeability
contraction of bronchioles
pruritis
pain

12

H2

Gs
increases gastric acid secretion via ECL cells acting on parietal cells

13

V1

Gq protein
Fxn: increases vascular smooth mm contraction

14

V2

Gs protein
Fxn:
increased water permeability and resorption in collecting tubules of kidneys (action is tied with ADH)