G Vs M Flashcards
(29 cards)
3 keto 4 ene
G and M required
20 keto group
G and M required
21 oh
Required for M not essential G
18 formyl
High increase M
11 B-OH
Required to be active for G not required for M
17 a-OH
Increase G decrease M
1-ene
Increase G decrease M
6 a-CH3
Increase G decrease M
16 a-OH
High decrease M
16 a-CH3
High decrease M
16 B-CH3
High decrease M
16 a, 17 a-metal
High decrease M
9 a-F
Increase G and M
9 a-Cl
Increase G and M
21-Cl
Increase topical activity
6 a-F
Increase G but not as much as 9
A ring aromatic and 3-OH
Phenol
E
D ring c17 HBA
E
Distance 10-12 A
E
1 or 4 sub on __ does __
E and inactivates
2-OMe or 2-F on __ does __
E and decrease activity to 2-5%
B ring unsaturated on __ does __
E decreases activity
11 B-OMe or 11 B-Et on__ does __
E increase activity
6,7 double bond on __ does __
P increases
