Gaba and Glutamate Flashcards Preview

SCT3 Neurology Topic 3 > Gaba and Glutamate > Flashcards

Flashcards in Gaba and Glutamate Deck (13)
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1
Q

What is the long form of GABA?

A

GAMMA - AMINOBUTYRIC ACID

2
Q

Name the most common inhibitory NT in the CNS?

A

GABA

GAMMA - AMINOBUTYRIC ACID

3
Q

What happens without GABA?

A

NERVE CELLS CAN FIRE TOO OFTEN

4
Q

Name the anxiety impairments related to low GABA activity?

A
PANIC ATTACKS
\+
SEIZURE DISORDER
\+
COGNITIVE IMPAIRMENT
5
Q

Agonists such as Valium and Librium ___________ GABA activity.

A

INCREASE

6
Q

Do GABA supplements cross the BBB?

A

NO

placebo effect

7
Q

Caffeine ___________ GABA release

A

INHIBITS

8
Q

___________ is the most common excitatory neurotransmitter in the CNS.

A

GLUTAMATE

9
Q

Name the NT involved in most aspects of normal brain function; including cognition, memory and learning?

A

GLUTAMATE

10
Q

Too much glutamate is harmful, what if you have too little?

A

ALSO HARMFUL

11
Q

_____________ use glutamate to destroy infected neurons, virus and bacteria.
(this causes large amounts of collateral damage to healthy neurons)

A

MICROGLIA

12
Q

Name the self-perpetuating cycle where, due to chronic inflammation, microglia can become over-activated?

A

REACTIVE MICROGLIOSIS

13
Q

What is though to be the underlying mechanism of progressive neuron damage across numerous neurodegenerative diseases, regardless of instigating stimuli?

A

REACTIVE MICROGLIOSIS
(chronic inflammation = over-activated microglia)
(we CAN help inflammation!)