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610 Anesthesia Concepts > GasLaws, Physics, and Math > Flashcards

GasLaws, Physics, and Math Flashcards

(92 cards)

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1
Q

Molecular Theory of Matter

A

states that matter is made of minute particles called molecules, that exist in various states (solid, liquid, or gas).

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2
Q

Kinetic Theory of Matter

A

states that molecules are in constant motion (random motion) and have a degree of attraction between them called van der waals forces.

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3
Q

Critical Temperature

A

the temp. above which a gas cannot be liquefied regardless of how much pressure is applied

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4
Q

Avagadro’s Hypothesis

A

Avagadro hypothesized that if you had 2 different containers containing 2 different gases at the same temp and pressure, then they contain the same number of molecules

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5
Q

Avagadro’s Number

A

1 mole - contains 6.02 x 10^23 molecules

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6
Q

What is one mole equivalent to?

A

One mole is one gram multiplied by the molecular weight: e.g. 1 mole 02 = 32 grams.

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7
Q

One mole of any substance occupies how many liters?

A

22.4 liters so: 6.02 x 1023 molecules of 02 = 32 grams and occupies 22.4 L.

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8
Q

Calibration of vaporizers are done using what?

Give an example using sevo

A

Avagadro’s Hypothesis

  • Molecular weight of Sevoflurane is 200, so 200 g Sevo is 1 mole, and would occupy 22.4L at s.t.p.
  • If we put 20g of Sevo (0.1 mole) into a vaporizer, and allow it all to vaporize, it would occupy 2.24 liters
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9
Q

Universal Gas Constant

A

By combining the perfect gas laws with Avagadro’s hypothesis we arrive at the following equation:
PV/T = Constant (k4), for any given quantity of gas

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10
Q

Boyle’s Law

A

The volume of an ideal gas is inversely proportional to the pressure—Thus as pressure ↑ the volume ↓
V = 1/P
temperature held constant

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11
Q

Application of Boyle’s Law with a reservoir bag

A

Applying pressure (squeezing it) causes the volume to decrease

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12
Q

Application of Boyle’s Law with an E cylinder

A

The relatively small volume of gas in the cylinder is at high pressure. When it is released to the atmosphere where there is a relatively low pressure, a large volume results
Pressure ↓ and Volume ↑

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13
Q

Application of Boyle’s Law with spontaneous breathing

A

When intrapulmonary pressure becomes negative (decreases), intrapulmonary volume increases

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14
Q

Application of Boyle’s Law with bellows on the ventilator

A

As pressure increases, the volume within the bellows decreases

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15
Q

Charles’ Law

A

Charles’s Law states that the volume of a given gas is directly proportional to the Kelvin Temperature provided the amount of gas & the pressure remains constant : V/T
temperature ↑ the volume ↑

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16
Q

Gay-Lussac’s Law

A

At constant Volume, the pressure of a gas sample is directly proportional to the Kelvin Temperature.
Thus as the temperature ↑ the pressure ↑

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17
Q

Application of Gay-Lussac’s Law

A

A full cylinder of compressed gas is moved from the air conditioned hospital (70 degrees) to the loading dock (100 degrees Fahrenheit)- What happens to the pressure in the cylinder???
-increased pressure

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18
Q

What remains constant in Boyle’s Law?

A

temperature

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19
Q

What remains constant in Charles’?

A

pressure

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20
Q

What remains constant in Gay-Lussac’s Law?

A

volume

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21
Q

Universal (Ideal) Gas Law

A

PV = nRT

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22
Q

Application of the Ideal Gas Law with a cylinder

A

As a cylinder of compressed gas empties, the pressure falls-
The cylinder has a constant volume. The number of moles (n) of gas decreases as gas exits the cylinder, so Pressure decreases

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23
Q

Dalton’s Law

A

states that in a mixture of gases, the pressure exerted by each gas is the same as that which it would exert if it alone occupied the container.

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24
Q

Application of Dalton’s Law using air

A

760 mmHg x 21% = 160mmHg, this is the partial pressure of Oxygen in the container

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25
What is the partial pressure for nitrogen?
760mmHg x 79% = 600mmHg
26
Application of Dalton's Law using a combination of inhaled anesthetic
Commonly used agents might be: 50% N20 .5x760 + 44% O2 .44x760 + 6% Desflurane .06x760 100% Mix to patient = 1.0 x760
27
What is MAC
the concentration of the vapor (measured as a percentage at 1 atmosphere, i.e the partial pressure) that prevents the reaction to a standard surgical stimulus in 50% of subjects.
28
What is physiologically important, the partial pressure or concentration?
The partial pressure (mm Hg), not the concentration. This is important to remember because atmospheric pressure changes. The concentration may change to keep the same partial pressure of an agent at a different atmospheric pressure
29
Fick's Law of Diffusion
Vgas= Area x Solubility x Partial pressure difference/ Molecular Wt x Distance
30
Clinical application of Fick's Law - 2nd gas effect
high inspired concentration of a first gas (N2O) accelerates uptake of a companion gas
31
Clinical application of Fick's Law - Concentration Effect
Uptake of high volumes of N2O concentrates the remaining 2nd gas
32
Graham’s Law
A gas diffuses at a rate that is inversely proportional to the square root of its molecular weight Thus as molecular weight ↑ the rate of diffusion ↓
33
Henry’s Law
The amount of gas dissolved in a liquid is directly proportional to the partial pressure of the gas in contact with the solution
34
What is an application of Henry's Law?
Allows calculation of O2 and CO2 dissolved in blood.
35
What is the solubility coefficient of O2? (its a constant)
.003ml/100ml blood/mmHg partial pressure
36
What is the solubility coefficient of CO2? (its a constant)
.067 ml/100ml blood/mmHg partial pressure
37
ABG: pH 7.44, PaO2 600mmHg, PaCO2 35mmHg, HCO3 25 | How much O2 and CO2 is dissolved in blood?
Multiply PaO2 x constant (.003)  600 x .003 = 1.8ml/100ml blood Multiply PaCO2 x constant (.067)  35 x .067 = 2.35 ml/100ml blood *application of Henry's Law
38
How can you estimate the PaO2?
when delivering certain amount of oxygen and multiplying FiO2 x 5.
39
Let's say you have 21% O2, estimate the PaO2 and the dissolved O2 in the blood.
21 x 5 = 105mmHg | 105mmHg x .003 = .315 ml/100ml blood.
40
Your delivering 40% FiO2 via face tent, estimate the PaO2 and the dissolved O2 in the blood.
40 x 5 = 200 mmHg; | 200 mmHg x .003 = .6ml/100ml blood.
41
Critical Temperature
The temp above which a substance goes into gaseous form in spite of how much pressure is applied.
42
T/F: A gas cannot be liquefied if the ambient temperature is greater than critical temperature
True
43
A gas cannot be liquefied if sufficient pressure is applied at ambient temp below the critical temperature
False; A gas CAN be liquefied if sufficient pressure is applied at ambient temp below the critical temperature
44
What is the critical temperature of oxygen?
-119 degree C
45
Can oxygen be liquified at room temperature? (25 degree C)
O2 cannot be liquefied at room temp no matter how much pressure is applied to it Recall: A gas can be liquefied if sufficient pressure is applied at ambient temp BELOW the critical temperature
46
How does the hospital store oxygen?
Liquid form; The containers are insulated from the outside and the temperature is kept at -160 degress C.
47
What is the critical temperature of nitrous oxygen?
39.5 degree C
48
Can nitrous oxide be liquified at room temperature? (25 degree C)
Yes; pressure can be applied to liquefy N2O at room temp
49
Adiabatic Cooling
The term adiabatic implies a change in temperature of the matter without gain or loss of heat
50
What is an example of adiabatic cooling?
N2O cylinder opened fully-> frost can form on the outlet due to cooling
51
Joule-Thompson Effect
Expansion of a gas causes cooling
52
What is an example of Joule-Thompson Effect?
As gas leaves a cylinder, the expansion cools the surrounding air causing condensation of moisture on the cylinder
53
Poiseuille’s Law
Q = pie r4 delta P / 8nL
54
Poiseuille’s Law is associated with what kind of flow?
Laminar
55
Give some clinical examples of Poiseuille’s Law?
IV Flow Airways Vascular flow – Polycythemia vs. Anemia Thorpe Tubes – at low flows
56
Density is a determinant of flow when it is..
turbulent
57
Viscosity is a determinant of flow when flow is..
laminar (low flow rates)
58
Reynolds number
velocity ∙ density ∙ diameter/viscosity
59
What number is associated with turbulent flow?
> 2000
60
Thorpe tube - low flow
the annular-shaped orifice around the float is tubular so (according to Poiseuille's Law) flow is governed by viscosity.
61
Thorpe tube - high flow
(indicated on the wider top part of the float tube), the annular opening is more like an orifice, and density governs flows.
62
What are three factors of that change flow from laminar to turbulent
Increased velocity Bend >20 degrees Irregularity in the tube
63
Bernoulli’s Theorem
The lateral wall pressure is LEAST at the point of greatest constriction and the speed is the GREATEST Thus, flow will be faster through the constricted portions and slower at the wider portions of a tube
64
What is an application of Bernoulli's Theorem?
Venturi tube
65
Explain the principle of the venturi tube
as the tube narrows, velocity of the fluid increases, thus dropping pressure - hence a sidearm on that portion of the tube can be used to aspirate another fluid into the tube.
66
Beer's Law
Absorption of radiation by a given thickness of a solution of a given concentration is the same as that of twice the thickness of a solution of half the concentration
67
Lambert's Law
Each layer of equal thickness absorbs an equal fraction of the radiation that passes through it
68
Clinical application of Beer-Lambert's Law
pulse ox
69
Carboxyhgb
FALSE HIGH reading
70
Methgb
If SaO2 > 85% FALSE LOW | If SaO2 < 85% FALSE HIGH
71
HgbF, HgbS, Polycythemia
No Effect
72
Methylene & Isosulfan Blue
FALSE LOW reading
73
Indocyanine Green & Indigo Carmine
slight decrease
74
Blue Nail Polish
FALSE LOW reading
75
Law of La Place
T=Pr
76
What are three clinical applications of LaPlace's Law?
- Normal Alveoli and the need for surfactant during expiration - Vascular Pathology- Aneurysm rupture due to increased wall tension - Ventricular volume and work of the heart- a dilated ventricle has greater tension in its wall (end diastolic pressure rises)
77
Ohm's Law
E (Voltage) = I(current flow or amp) R(resistance) | E=IR
78
What are two applications of ohm's law?
- Strain Gauges in Pressure Transducers | - Thermistors
79
How is a patient in the OR at risk for burns?
Metal is a good conductor, your patient is lying on a metal bed, surgery causes bleeding, blood is wet, the room is full of electrical equipment
80
Macroshock
Current distributed through the body, culprit: faulty wiring, improper grounding
81
Microshock
Current applied in or near the heart, culprit pacing wires, fault equipment during cardiac cath
82
What are the amounts of amps and injuries associated with them in reference to macroshock
- 1 milliamp  skin tingling/perception - 5 milliamps maximal “harmless” current - 10-20 milliamps  let go of source - 50 milliamps  pain, LOC, mechanical injury - 100-300 milliamps  V-Fib, resp intact - 6000 milliamps complete physiologic damage
83
How many amps is required to cause harm with microshock?
50 - 100 microamps  V-Fib
84
2% Lidocaine
2 grams of Lidocaine in 100 mL 2000 mg in 100 mL 20 mg in 1 mL
85
1% Lidocaine
1 gram in 100 mL 1000mg in 100 mL 10 mg in 1 mL
86
0.75% Bupivicaine
0. 75 grams in 100 mL 750. 0 mg in 100.0 mL 7. 5 mg in 1 mL
87
1:100,000 Epinephrine
``` 1 gram Epinephrine in 100,000 mL 1000 mg in 100,000 mL 1mg in 100 mL 1000 mcg in 100 mL 10 mcg in 1 mL ```
88
1: 1000 Neostigmine
1 gram in 1000 mL 1000mg in 1000 mL 1mg/mL
89
Epinephrine 1: 10,000
``` 1 gram in 10,000 mL 1000 mg in 10,000 mL 1mg in 10mL 1000 mcg in 10mL 100 mcg/mL (OR 0.1 mg/mL) ```
90
Epinephrine 1: 200,000
``` 1 gram in 200,000 mL 1000mg/200,000 mL 1mg/200mL 1000 mcg/200mL 10 mcg/2mL = 5 mcg/mL ```
91
2% Lidocaine with Epinephrine 1:200,000 | What is in EACH mL??
2% means 2 grams per 100 mL 2000 mg/100 mL = 20 mg/mL 1:200,000 means 1 gram per 200,000 mL 1000 mg/200,000 mL= 1mg/200 mL = 1000 mcg/200 mL = 10 mcg/2mL = 5 mcg/mL
92
2% Lidocaine with Epinephrine 1:200,000 | How much is each in 5ml?
EACH ml contains 20 mg Lidocaine AND 5 mcg Epinephrine 100mg Lido and 25mcg of Epi

610 Anesthesia Concepts (6 decks)

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