Gastro Drugs

Question 1

Cimetidine is weak and famotidine is strong, when do these H2 blockers work best?

Answer 1

At night

Question 2

Inflaximab and Adalimumab treat IBD MOA?

Answer 2

Anti-TNF

Question 3

Psyllium and Methylceullose are both what class of drugs?

Answer 3

Bulk-forming Laxatives

Bulky Seaweed

Question 4

Diphenoxylate Dolphin and Floppy ear Lopearmide’s mmain use?

Answer 4

Stop Diarrhea

Question 5

Odansetron and Granisetron block vomiting via MOA?

Answer 5

5-HT3 Serotonin inhibition

Question 6

Name the main Anti-integrin agent used to treat IBD

Answer 6

Natalizumab

Question 7

Sucralfate MOA to promote mucosal defense?

Answer 7

Binds and coats ulcer tissue under ACIDIC conditions

Question 8

After 5-ASAs, antibiotics, and corticosteroids are used, what Puine-Synth Inhibiting 2 drugs are next up for IBD treatment?

Answer 8

• Azathioprine

- 6-Mercaptopurine

Question 9

Cimetidine, Ranitidine, and Famotidine are all ____ blockers that reduce gastric acidity

Answer 9

H2

Question 10

Natalizumab treats IBD via what MOA?

Answer 10

Integrin

Question 11

What two COX & Lipoxy Blocker drugs are used to treat IBD first line and what overall class do they belong to?

Answer 11

• Mesalamine and Sulfasalazine

- 5-Aminosalicylates

Question 12

Ustekinumab treat BOTH CD and UC MOA?

Answer 12

IL-12/23 blocker!

Question 13

Main misoprostol mucosal defense contraindication?

Answer 13

Pregnant women

Question 14

3 1st line mild treatments for IBD

Answer 14

1. 5-ASA (Mesalamine)
2. 5-ASA (Sulfalazine)
3. Budesonide

Question 15

What is the D2 Anatgonist Metoclopramide’s main use?

Answer 15

Promote GI motility in post-surgical patients

Question 16

Apreptiant blocks vomit MOA?

Answer 16

Neurokinin Receptor Antagonist

Question 17

Diphenoxylate dolphin and Floopy ear loperamide stop diarrhea by what MOA?

Answer 17

m-Opoid agonist

Question 18

Docusate is what class of drug/mech?

Answer 18

Stool softener promoting water

Question 19

Name the 2 main Anti-TNF agents used to treat IBD

Answer 19

1. Inflaximab

2. Adalimumab

Question 20

How does Linaclotide promote motility?

Answer 20

• CFTR guan cyclase boost

Question 21

5-ASA, Budesonide, Azathiprine, 6-Mercapto, Inflaximab, Adalimumab, and Ustekinymab are all used to treat

Answer 21

Irritable Bowel Disease

Question 22

Lactulose and Magnesium Citrate and PEG main use

Answer 22

Rapid Bowel Purge

Question 23

Name the main anti-IL-12/IL-23 uesd to treat BOTH CD and UC?

Answer 23

Ustekinumab

Question 24

Considering its MOA What drugs should you avoid when taking Sucralfate to promote mucosal defense?

Answer 24

H2 Blockers of PPis because it needs acidic environ

Question 25

Azathiprine and 6-Mercaptopurine MOA to treat IBD?

Answer 25

Block purine synth

Question 26

Omeprazole MOA and 2 Key Risk?

Answer 26

• IRR ATPase block

- Osteoporosis & dementia

Question 27

Name the two main Serotonin antagonists for Anti-emsis

Answer 27

1. Odansetron

2. Granisteron

Question 28

Name the main Neurokinin Receptor antagonist Antiemtic drug?

Answer 28

Aprepitant

Question 29

What is the CFTR booster Linaclotide’s 2 main usage?

Answer 29

Constipation and Irritable bowel syndrome

Question 30

Misoprostol MOA to promote mucosal defense?

Answer 30

Prostaglandin E2 Analog

Question 31

How does Metoclopramide promote GI motility?

Answer 31

D2 Antagonist boosts gastric emptying

Question 32

5-ASA Mesalamine and Sufalazine MOA

Answer 32

Inhibit inflamm mediators

Question 33

Octreotide MOA

Answer 33

SST Analog

Question 34

Senna MOA

Answer 34

Direct Enteric nervous system stimulation

Tanning Mnemonic

Question 35

Lactulose and Magnesium Citrate and PEG are all ______

Answer 35

Osmotic Laxative