Gastrointestinal Flashcards

1
Q

what is GORD?

A

gastroosphgeal reflux disease is when the stomach content is regurgitated back up the oseaphgus often causing pain.

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2
Q

symptoms of GORD

A
burning sensation
stomach ache
crying 
vomiting 
poor feeding 
irritable
arching due to discomfort 
respiratory problems-aponea, cough, wheeze
bloating 
heartburn
increased salivation
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3
Q

common reason in infant

A

immature spinchter
milk based diet
forever lying down

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4
Q

how many resolve?

A

90% by one years of age

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5
Q

risk factors for gord

A
premature
family history
obesity 
hiatius hernia
congenital diaphragm hernia repair or congenital oesophageal atresia 
neurodisability 
overfeeding
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6
Q

investigations

A
clinical based on history
bloods-anaemia 
24 ph monitoring 
barium meal if bile stained
endosocpy
manometry
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7
Q

management

A
lifestyle advice- sit up when feeding and after for abit
ensure not overfeeding 150ml/kg/daily
reassure this is normal 40% of babies
add thickener to milk
trial of gaviscon
can consider PPI H2RA
nissen fundoplication  if no improvement
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8
Q

when would you consider a referral

A
haemetesis
melena
dysphagia
no improvement after one years old
faltered growth due to gord
Pain needing ongoing therapy
suspected diagnosis of sandifers syndrome
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9
Q

what is sandiier syndrome

A

gastro-oesophageal reflux disease + spastic torticollis +dystonic body movements

with or without hiatal hernia.

positioning of the head –> relief from abdominal discomfort caused by acid reflux (hypothesis)

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10
Q

what is gastroenteritis

A

sudden diarrhoea and vomiting
mostly caused by viral infection
resolves within a few days but care must be taken to prevent dehydration

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11
Q

whats notifable

A

food poisoning and dysentry

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12
Q

causes

A

viral-rotavirus, noravirus

bacterial-campylobacter, salmonella, shigella and ecoli

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13
Q

rf

A

poor hygeine
poor handling of meat/uncooked meat
immunocompromised

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14
Q

clinical features of gastroenteritis

A
diarrhoea
vomiting
fatigue
abdopain
febrile
recently been on abx -c.ddiffle
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15
Q

what are red flags

A

signs of dehydration and shock

hypotension
tachycardia
reduced skin turgor
sunken eyes
altered responsiveness
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16
Q

investigations

A

mc and s if septicaemia ,blood, mucus, immunocompromised, recent travel ,> 7 days
FBC, UE, cup cultures

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17
Q

management

A
home management unless signs of shock 
do not give solid food
continue on liquids
avoid sugary and carbonated drinks
give milk
wash hands and do not share towels
use ORS 
48 hour symptom free before returning to school /nursery

do not give anti diarrhoeals

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18
Q

when are antibiotics given

A

if suspected septicaemia

salmonella in under 6 months, immunocompromised or malnourished

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19
Q

what is the definition of constipation

A

2 or more of the following over 8 week period or more:
pain on defectation
large tutti felt rectally or palpable from stomach
Megatron tutti blocking toilet
retentive posture or posture behaviour
more than 1 episode per week of fetal incontinence
less than 3 motions per week

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20
Q

presentation

A
straining 
pain 
dry
anorexia
reduced growth
abdo distention
involuntary soiling
abnormal anal tone
fresh rectal bleeding
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21
Q

causes

A

lack of fibre
lack of water
lack of exercise
poor colonic motility-fox in 55%

gi causes IBS, Coeliac, hypertensiitvty to food, Hirschsprung disease, anal disease, obstruction

non gi causes- hyeprcalcemia,
hypothyroidism, sexual abuse, opioids, diabetes inspidius

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22
Q

diagnosis

A

organic causes- coeliac antibody screen, tfts, calcium, biopsy, abdo xray

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23
Q

management

A
treat cause
give fluids and fibre 
natural laxative-orange juice
anal fissure 2% lidocaine ointment
oral magnum citrate and magnum phosphate to clear bowels
enemas
manual evacuation in hospital

fecal softeners movicol
stimulant laxatives- Senna

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24
Q

what is appendicitis ?

A

the most common surgical emergency
peaks between 10-30 years of age
inflammation of the appendix
cause unknown

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25
Q

how does appendicitis present

signs and symptoms

A
umbilical generalised pain which moves to rif constant sharp pain 
loss of apetite
nausea
dysuria
associated with anorexia
rising pulse
low grade fever
guarding at mc burney point
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26
Q

what makes pain worse

A

movement

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27
Q

three signs

A

rosving- palpation in left iliac fossa causing pain in rif
psoas- hip flexed, pain
obturator-internal rotation of hip with stabilised ankle-pain

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28
Q

where is mc burney point

A

one-third of the distance from the anterior superior iliac spine to the umbilicus (navel

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29
Q

diagnosis of appendicitis

A
clinical diagnosis
but bloods  -neutrophilia, leucocytosis 
urinalysis protein
abdominal and pelvic CT scan
urinary pregnancy test in females

consider USS

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30
Q

scoring systems used of appendicitis

A

alvarado score of 7 for appendiectomy - 6 clinical features, 2 lab features

RIPASA

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31
Q

management of appendicitis

A

fluids
surgical appendiectomy
abx prophylaxis

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32
Q

thing to remember in appedicitis in children

A

may appear better temporarily if perforated

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33
Q

complications of appendicitis

A
peritonitis
perforation
infection 
abscess
sepsis
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34
Q

differentials

A

ectopic pregnancy
crohns disease
UTI
mesenteric adentitis

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35
Q

8 features of Alvarado

A

abdominal pain that migrates to the right iliac fossa 1
Anorexia (loss of appetite) or ketones in the urine 1
Nausea or vomiting 1
Tenderness in the right iliac fossa 2

Signs
Rebound tenderness (Blumberg) 1
Fever of 37.3 °C or more 1

Laboratory
Leukocytosis > 10,000 2
Neutrophilia > 70%

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36
Q

what is coeliac disease

A

autoimmune mediated enteropathy on exposure to gluten in genetic predisposed individuals

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37
Q

who is coeliac more common in

A

females
50s and infancy
caucasians

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38
Q

key finding on bloods in coeliac

A

anaemia

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39
Q

symptoms of coeliac disease

A
steatthorea
constipation
diarrhoea
bloating
fatigue
failure to thrive
abdo distention
flatulence 
vitamin D,E,K, A defieency , selenium due to malabsorption
weight loss
dermatitis herpeformis
recurrent mouth ulcers
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40
Q

complications of coeliac disease

A
other autoimmune condition
lymphoma
anaemia
osteoporosis
infertility
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41
Q

diagnosis

A
bloods- anti TTG, EMA, IgA 
genetic tests HLADQ8 and 2
endoscopy
biopsy
marsh grading 0-4 
check vitamin b12, d, 
exlude hypothyroidism 
osteoporosis screen
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42
Q

managing coeliac in paedds

A

followed up six to 12 months after diagnosis followed by a yearly check up after
annual an antibody blood test every year or less often. Another biopsy may be offered - not carried out routinely.

Children should also have their height and weight checked to monitor their growth and development.

gluten free diet
prevent nutritional/vitamin deficiencies with supplementation

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43
Q

what is Hirschsprung disease

A

the absence of ganglion cels from the mesenteric plexus as part of the large bowel
causing a narrow contracted segment

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44
Q

where in the bowel is Hirschsprung disease

A

extends from rectum to dilated colon

75% rectosigmoid but 10% can affect entire colon

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45
Q

presention of hirschsprung disease

when may it present late

A

neonatal period with intestinal obstruction - with meconium not passing within first 24-48 hours
bile stained vomiting
abdominal distention

if short segment of bowel is affected
if presents later, failure to thrive, constipation, overflow incontinencne

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46
Q

what do you need to be aware of when examining for Hirschsprung

A

rectal examination can temporarily relieve the symptoms as removal of finger causes watery stool and flatuence. this can delay diagnosis

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47
Q

diagnosis of Hirschsprung

A
abdo xray and enema-airless rectum and dilated bowel
anaorectal mamometry
suction rectal biopsy 
barium studies 
biopsy from rectum
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48
Q

what can Hirschsprung be associated with

A

down syndrome

endocrine neoplasias

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49
Q

a complication to be aware of

A

enterocolitis -12 % incidence can be life threatening

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50
Q

management of Hirschsprung
if entercolitis
and obstruction also

A

colostomy followed by anastomosing innervated bowel to anus
antibiotics if enterocolitis suspected
and if obstruction ng tube, fluids and cessation of oral food and fluids

51
Q

what is mesenteric adenitis

A

commonly affects children and adults
caused by inflammation and swelling of lymph nodes in the mesentery
less serious than appendicitis and usually self limiting

52
Q

presentation of mesenteric adenitis

A
nausea and vomiting
diarrhoea
fever
malaise
weight loss
pain in lower right abdomen
53
Q

when does mesenteric adenitis usually occur

A

post viral infection, cold, gastroenteritis

54
Q

what are common causes

A
coxsackie virus
recent hiv virus
adenovirus 
Bartonella henselae
beta haemolytic streptococci
ecoli
giardia lambia
55
Q

another name for Bartonella henselae

A

cat scratch disease

56
Q

diagnosis

A

clinics
bloods to look for infection
CT scan
uss

57
Q

management

A

self limiting
antibiotics
pain relief

58
Q

what is it associated with

A

lower risk OF UC

59
Q

what can be undercooked caused by what?

A

pork

yersinia enterocolitica

60
Q

complications

A
dehydration
abscess
arthlagia 
peritionitis
sepsis
61
Q

what is testicular torsion?

A

it is the most common urological emergency
occurs when the spermatic cord has twisted cutting off blood supply to the teste- very very rare to be bilateral
the reduced blood flow can cause it to die therefore immediate management is necessary.

62
Q

causes

A

some at risk (unaware of this risk) due to weak connective tissue in scrotum called a bell clapper deformity making testicle more mobile and more likely to twist
injury/trauma
rapid growth In teens

63
Q

symptoms of testicular torsion

A
sharp sudden pain 
swelling of scrotal sac
diziness
nausea
vomiting
lump in sac
blood in semen
64
Q

differentials of testicular torsion

A

epididmytitis

intermittent torsion -should still seek help as may occur again

65
Q

diagnosis

A

physical exam-soreness, swelling, pinch inner thigh and loss of cremaster relfex
imaging- USS for blood flow

66
Q

treating testicular torsion

A

should never ignore testicular pain
surgical repair- restore blood flow under general anasthetia
suture in place to prevent reoccurrence

67
Q

what is biliary atresia

A

it is a progressive serious condition in childhood with obstruction of the extra hepatic biliary tree and can extend to intraheptic
occurs as inflammation leading to fribosis and scarring either in neonatal period or in utero

68
Q

presentation

A

jaundice
pale stool-dark urine
especially if >14 Days long
hepatomegaly

69
Q

what value of conjugated bilirubin can aid diagnosis

A

higher than 34.2 micromol/L

70
Q

10-20 out of 100 cases of biliary atresia will have

A

polysplenia or asplenia
intestinal malrotation
heart defects

71
Q

diagnosis of biliary atresia

A
blood tests
urine tests
liver excretion tests
chlorigiogram
USS
biopsy
72
Q

complications of biliary atresia

A
portal hypertension
ascites
cholangiits
prituitis
growht failure
73
Q

mangement

A

hepatoportenterstomy in infants where esld
BUT WILL MOST LIKELY NEED transplant within first few years
kasai procedures within first few months

74
Q

thing to consider about the procedure

A

low success rates if left

75
Q

what is a hernia?

A

protrusion of abdominal content through fascia of abdominal wall through the internal inguinal ring
always contain peritoneal sac

76
Q

who is more common to have an inguinal hernia?

A

males x8 more likely

77
Q

risk factors for intra-abdominal hernias

A
  • those with a condition which increases intra abdominal pressure such as cf
    connective tissue disorders
    males
    prematurity
78
Q

clinical presentations of hernias

A

swelling
palpable mass
may be increased on lying down or coughing or when standing
dragging esensation

79
Q

boundaries of the inguinal canal

A

floor- inguinal ligament
anterior-aponeurosis of the external oblique
roof-transverse abdominal , internal oblique
posterior-transverse fascia, transverse abdominis

80
Q

difference between direct and indirect

A

direct- directly through weakness in posterior woall MEDIALLY to inferior epigastric vessels
indirect- through internal inguinal ring along canal , ;laterally to epigastric vessels

81
Q

what is a sliding hernia

A

visceral behind the perineal sac slides into the canal with the wall of the organ forming part of the hernial sac

82
Q

investigations

A

USS if unclear diagnosis

83
Q

management

A

herniotomy - ligation nd excision of the processes vaginalis
surgical laparoscopic repair after diagnosis in healthy full-tern infants boys with reducible hernias

84
Q

complications

A

12-16% incidence of strangulation in paediatrics
50% of which underr 6 months of age
recurrence rate increases in failure to grow, prematurity, sliding hernias in girls, chronic resp problems, infarcted testes

85
Q

which is more common in children

A

indirect
80%
failure of canal to close

86
Q

what is pyloric stenosis

A

muscle/sphincter between stomach (distal end) and small intestine called the pylorus. the muscle thickens causing a narrowing - as a result, food cannot move into small intestines as easily or at all

87
Q

symptoms of pyloric stenosis

A
projectile vomiting
constipation
persistent hunger 
weight loss
dehydration and reduced wet nappies in babies
88
Q

when does pyloric stenosis commonly occur

A

infancy < 3 months especially

89
Q

risk factors for pyloric stenosis

A
first born
males
caucasians
prematurity
family history
smoking in pregnancy x2 risk 
early antibiotic exposure- erythromycin
bottle feeding
90
Q

diagnosis

A

chemistry panel
USS
clinical-project vomititng

91
Q

complications of pyloric stenosis

A

failure to grow and develop
dehydration
irritation -> mild bleeding
jaundice

92
Q

management

A

pyloromyotomy - incision in thickened muscle to allow passage of food etc through

93
Q

what is intussusception

A

when the intestine folds into the section next to it - known as telescoping , this usually affects small bowel and blocks intestine thus preventing food or liquid from passing - can also cut of blood supply

94
Q

symptoms

A
intermittent abdo pain -can be colicky 
vomiting 
diarrhoea
poor feeding
bloody stools 
bloating and abdo distention
lump in abdo
lethargy
95
Q

key significance of intusseption

A

commonest cause of obstruction in under. 3 year olds

96
Q

risk factors for intussusception

A
6 months to 3 years of age
b>f 
intestinal malrotation history
increased risk if previously had it
family history
viral illnsess
97
Q

management

A

emergency admission
fluids to tackle dehydration and NG tube to decompress intestine
enema
surgery -> tree trapped position

98
Q

complications

A

peritonitis

perforation

99
Q

diagnosis

A

abdo xray showing dilation - target sign
uss
eneme air or barium
ct

100
Q

what is toddlers diarrhoea?

who

A

it a common cause of chronic diarrhoea in young children affecting 1-5 years of age and is more common in boys

101
Q

symptoms of toddlers diarrhoea

A
chronic non specific diarrhoea
often 3-4 or more watery stools a day sometimes odorous stools
paler than usual stools
mild abdominal pain
constipation and alternating diarrhoea
102
Q

what is the management for it

A

reassurance
improves with age
also advice regarding 4 Fs
fat- low fat diet can trigger it as babies need high fat diet
fluid and fruit juices- too many juices can trigger it as of sugar content
fibre- too high or low fibre diet

103
Q

what is undescended testicles

A

testicles in boys move into the scrotum 1-2 months before birth
sometimes this has not occurred so the testicle is not in the scrotum
1 in 25 births
usually detect at newborn or 6-8 week examination

104
Q

what are the risk factors for an undescended testicle

A

prematurity
family history
low birth weight

105
Q

how is it diagnosis?

A

on examination but usually keyhole laparoscopy is used

106
Q

when do you manage?

A

allow to descend naturally but if not done by 6 months then likely to need surgery which should be done before 12 months (1 in 100 will need treatment)
orchidopexy to move to correct place

107
Q

what is retractile testicles

A

testitcles which move in and out of the scrum usually changing position as a result of temperature, changes feeling fear or excitment
most settle in place with age but may need monitoring as In some cases doesn’t descend and settle.

108
Q

what is jaundice?

A

jaundice is the comment sign of liver disease and can indicate haemolysis if outside of the newborn pjhase. caused by accumulation of bilirubin in the skin which is produced from the breakdown of haemoglobin. bilirubin is conjugated in the liver so it can be excreted.

109
Q

jaundice occurs when…

A

bilirubin is > 25-30mmol/L
unconjugated- when total bilirubin increased with less than 15% in conjugated form
conjugated- same as above but <20% in conjugated form.

110
Q

multiple causes of jaundice such as

A

viral hep,EBV, cmv, hsv
metabaolic causes such as alpha antitrypsin one deficiency -autosomal dominant
wilson disease
CF

inherited syndromes such as criglar najjar-autosomal recessive e-UDP enzyme lacking
Gilbert syndrome also recessive - mutation in UGTI impaired UDL glut. transference enzyme thus unable to conjugated bilirubin effectively

haemolytic anaemias
haemoglobinopathies
G6PD deficiency
hereditary spheroctyosis

bilary tract disorders such as cholecystitis, autoimmune liver disease

hepatotoxins such as paracetamol overdose, OCP, anti-convulsants, alcohol

budd chiari disease

111
Q

symptoms and history

A
yellowing of sclera, skin
pale stools 
dark urine 
malaise
fever
pruritisis
anaemia 
sterrhoea -can indicate cirrhosis

look out for other gi features such as spider nevi, hepatic flap etc

112
Q

hepatitis a

A

acute
vaccine available
feceal oral

113
Q

hep b

A

acute or chronic
no treatment cure but there is preventive vaccine
vertical transmisison
body fluids

114
Q

hep c

A

body fluids ,needle sharing, vertical transmission
can be chronic
no vaccine but there is now an expensive cure

115
Q

hep d

A

can only acquire in presence of HEP B needs it as a carrier

can be chronic

116
Q

hep e

A

feceal oral route
acute
often cattle, poultry etc
ensure drinking safe water

117
Q

inflammatory bowel disease

A

UC and CD

cd twice as common

118
Q

differences between UC and CD

A

uc -Continous red mucosal involvement, always starts in rectum, blood diarrhoea, confined to colon and rectum only

cd- skip patch lesions, granulomatous, transmural, cobblestone appearance, affects anywhere between anus and mouth

119
Q

what is important to note regarding antidiarrhoeals

A

do not give in active colitis. increased toxic megacolon risk

120
Q

symptoms of IBD

A
diarrhoea
bloody
abdo pain
weight loss
letheragy
arhtrtis
fever
ulcers in crohns
121
Q

diagnosis of bid

A
endoscopy
stool samples 
colonscopy
biopsy
barium studies
122
Q

which of the two is associated with colonic malignancies

A

UC

123
Q

treatment of iBD

A

MESALAZINE
STERIODS
azathioprine
immunosuppresives - inflimixab

124
Q

what is volvulus?

A

A volvulus is when a loop of intestine twists around itself and the mesentery that supports it, resulting in a bowel obstruction. Symptoms include abdominal pain, abdominal bloating, vomiting, constipation, and bloody stool.